Protein: KLH12
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)

Gene: KLH12, KLHL12
Organism: Homo sapiens
Interactions: 151
UniProt ID: Q53G59

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006513 - protein monoubiquitination
GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0014029 - neural crest formation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1113267

CUL3
Cullin-3

18

20

Small-scale

0.989

High

1198978

KLH12
Kelch-like protein 12

9

19

Small-scale

0.976

High

329071

KLHL2
Kelch-like protein 2

8

19

Small-scale

0.968

High

1199049

FXL17
F-box/LRR-repeat protein 17

6

15

Small-scale

0.957

High

856723

BAG6
Large proline-rich protein BAG6

5

3

Small-scale

0.933

High

1199050

KLHL3
Kelch-like protein 3

4

19

High-throughput

0.895

High

1198984

KLH24
Kelch-like protein 24

3

19

High-throughput

0.836

High

1198979

KLH26
Kelch-like protein 26

4

19

Small-scale

0.788

High

1199047

PEF1
Peflin

8

3

Small-scale

0.754

High

508080

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

8

Small-scale

0.754

High

1199044

ZBTB4
Zinc finger and BTB domain-containing protein 4

2

0

High-throughput

0.742

High

1112525

CUL1
Cullin-1

2

20

Small-scale

0.737

High

323878

SC31A
Protein transport protein Sec31A

5

1

Small-scale

0.721

High

1199013

DVL3
Segment polarity protein dishevelled homolog DVL-3

5

10

Small-scale

0.717

High

140293

SDCB1
Syntenin-1

4

6

High-throughput

0.707

High

1199019

NTAQ1
Protein N-terminal glutamine amidohydrolase

4

3

High-throughput

0.707

High

832732

BCL6
B-cell lymphoma 6 protein

2

1

High-throughput

0.700

High

1154842

NEDD8
Ubiquitin-like protein NEDD8

1

1

High-throughput

0.691

High

276475

PDCD6
Programmed cell death protein 6

3

3

Small-scale

0.678

High

1199043

PRR13
Proline-rich protein 13

4

0

High-throughput

0.675

High

325386

INMT
Indolethylamine N-methyltransferase

3

2

High-throughput

0.675

High

484154

PGFRB
Platelet-derived growth factor receptor beta

3

4

High-throughput

0.675

High

637550

FLNA
Filamin-A

3

1

High-throughput

0.675

High

1023941

EM55
55 kDa erythrocyte membrane protein

3

2

High-throughput

0.675

High

1198982

TTBK2
Tau-tubulin kinase 2

3

1

High-throughput

0.675

High

1198998

TB10C
Carabin

3

1

High-throughput

0.675

High

1199008

LNX1
E3 ubiquitin-protein ligase LNX

3

7

High-throughput

0.667

High

1199003

ARRD1
Arrestin domain-containing protein 1

3

3

High-throughput

0.665

High

1199002

Q8N4I8
KLHL3 protein

1

19

High-throughput

0.665

High

159677

DVL2
Segment polarity protein dishevelled homolog DVL-2

3

8

Small-scale

0.660

High

938224

SEC13
Protein SEC13 homolog

3

2

Small-scale

0.656

High

1199038

PKHA4
Pleckstrin homology domain-containing family A member 4

3

1

High-throughput

0.653

High

1121411

KEAP1
Kelch-like ECH-associated protein 1

1

19

Small-scale

0.647

High

1198991

SNX20
Sorting nexin-20

4

3

High-throughput

0.644

High

927334

ATX1
Ataxin-1

2

4

High-throughput

0.643

High

159358

DVL1
Segment polarity protein dishevelled homolog DVL-1

2

8

Small-scale

0.629

High

1199011

FUBP2
Far upstream element-binding protein 2

2

2

Small-scale

0.624

High

889923

VEGFB
Vascular endothelial growth factor B

4

1

High-throughput

0.623

High

1199005

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

18

Small-scale

0.618

High

1198986

CCBE1
Collagen and calcium-binding EGF domain-containing protein 1

3

5

High-throughput

0.616

High

1199029

C1QT2
Complement C1q tumor necrosis factor-related protein 2

3

6

High-throughput

0.616

High

320691

UBXN7
UBX domain-containing protein 7

2

3

High-throughput

0.611

High

1116660

RIN1
Ras and Rab interactor 1

2

2

High-throughput

0.606

High

1152085

MARE1
Microtubule-associated protein RP/EB family member 1

2

2

High-throughput

0.606

High

1198989

CSN6
COP9 signalosome complex subunit 6

2

10

High-throughput

0.601

High

1199010

CSN5
COP9 signalosome complex subunit 5

2

12

High-throughput

0.601

High

1199060

TACC3
Transforming acidic coiled-coil-containing protein 3

2

7

High-throughput

0.601

High

175068

SC16A
Protein transport protein Sec16A

2

2

Small-scale

0.584

High

1148893

SC23A
Protein transport protein Sec23A

2

2

Small-scale

0.584

High

1148982

SC23B
Protein transport protein Sec23B

2

2

Small-scale

0.584

High

993602

UBC9
SUMO-conjugating enzyme UBC9

2

10

High-throughput

0.584

High

1004651

RNF4
E3 ubiquitin-protein ligase RNF4

2

0

High-throughput

0.580

High

1187153

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

2

0

High-throughput

0.580

High

931534

RD23A
UV excision repair protein RAD23 homolog A

1

3

High-throughput

0.575

High

1094345

CSN1
COP9 signalosome complex subunit 1

1

15

High-throughput

0.575

High

1115232

CUL4B
Cullin-4B

1

20

High-throughput

0.575

High

1130006

KCTD2
BTB/POZ domain-containing protein KCTD2

1

3

High-throughput

0.575

High

1198983

KLH17
Kelch-like protein 17

1

19

High-throughput

0.575

High

1199045

KLHL9
Kelch-like protein 9

1

19

High-throughput

0.575

High

1199046

KLH13
Kelch-like protein 13

1

19

High-throughput

0.575

High

1199053

KLH21
Kelch-like protein 21

1

19

High-throughput

0.575

High

1199056

KLH20
Kelch-like protein 20

1

20

High-throughput

0.575

High

1199059

IPP
Actin-binding protein IPP

1

19

High-throughput

0.575

High

1198992

FGD2
FYVE, RhoGEF and PH domain-containing protein 2

1

3

High-throughput

0.573

High

1198999

NUDC3
NudC domain-containing protein 3

2

20

Small-scale

0.571

High

1199058

ARI1
E3 ubiquitin-protein ligase ARIH1

2

13

High-throughput

0.571

High

1198985

CRTC3
CREB-regulated transcription coactivator 3

1

1

High-throughput

0.560

High

1198988

Q7KZS0
SUMO-conjugating enzyme UBC9

2

10

High-throughput

0.558

High

1199006

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

2

High-throughput

0.553

High

958649

CSN2
COP9 signalosome complex subunit 2

2

19

High-throughput

0.552

High

1199000

GLCTK
Glycerate kinase

1

0

High-throughput

0.549

High

163954

NDC80
Kinetochore protein NDC80 homolog

1

4

High-throughput

0.541

High

521373

ARAF
Serine/threonine-protein kinase A-Raf

1

3

High-throughput

0.541

High

1160150

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

3

High-throughput

0.541

High

1199040

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

1

High-throughput

0.541

High

1199054

TAOK2
Serine/threonine-protein kinase TAO2

1

6

High-throughput

0.541

High

992203

SKP1
S-phase kinase-associated protein 1

1

4

High-throughput

0.536

High

1046369

UBXN1
UBX domain-containing protein 1

1

3

High-throughput

0.536

High

1198995

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

4

High-throughput

0.536

High

1199018

DCNL1
DCN1-like protein 1

1

9

High-throughput

0.536

High

1199022

SCYL1
N-terminal kinase-like protein

1

4

High-throughput

0.536

High

1199001

SYNE4
Nesprin-4

1

1

High-throughput

0.523

High

822698

VHL
von Hippel-Lindau disease tumor suppressor

1

4

High-throughput

0.515

High

843625

HD
Huntingtin

1

1

High-throughput

0.515

High

1198994

Q86TH3
Dishevelled, dsh homolog 1

1

7

High-throughput

0.515

High

1199021

MY15B
Unconventional myosin-XVB

1

5

High-throughput

0.515

High

94314

D6R9G5
Kelch like family member 2

1

18

High-throughput

0.514

High

694346

CO8A1
Collagen alpha-1(VIII) chain

1

7

High-throughput

0.494

High

702971

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.493

High

1058769

COGA1

1

7

High-throughput

0.489

High

1199015

MED12
Mediator of RNA polymerase II transcription subunit 12

1

4

High-throughput

0.489

High

1199028

CAR10
Caspase recruitment domain-containing protein 10

1

6

High-throughput

0.481

High

1199035

ZBP1
Z-DNA-binding protein 1

1

1

High-throughput

0.481

High

338489

SC24B
Protein transport protein Sec24B

1

2

Small-scale

0.479

High

400934

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

732614

ARRB2
Beta-arrestin-2

1

1

Small-scale

0.479

High

882504

ARRB1
Beta-arrestin-1

1

1

Small-scale

0.479

High

957409

UBC12
NEDD8-conjugating enzyme Ubc12

1

14

High-throughput

0.479

High

1109784

HDAC1
Histone deacetylase 1

1

1

High-throughput

0.479

High

1199009

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1199014

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

5

Small-scale

0.479

High

1199051

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

12

Small-scale

0.479

High

1199061

S23IP
SEC23-interacting protein

1

1

Small-scale

0.479

High

1155433

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.470

High

60223

A2RRL9
Z-DNA-binding protein 1

1

1

High-throughput

0.470

High

384286

CO3A1

1

6

High-throughput

0.470

High

1165253

Q17RA1
Caspase recruitment domain-containing protein 10

1

4

High-throughput

0.470

High

1198990

Q7LAP4
Vascular endothelial growth factor B

1

1

High-throughput

0.470

High

869751

MTR1A
Melatonin receptor type 1A

1

3

High-throughput

0.464

High

1142784

PEA15
Astrocytic phosphoprotein PEA-15

1

0

Small-scale

0.460

High

766609

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

1198981

OBI1
ORC ubiquitin ligase 1

1

0

Small-scale

0.458

High

1199041

RNC
Ribonuclease 3

1

0

High-throughput

0.458

High

1056768

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.457

High

991560

DYL1
Dynein light chain 1, cytoplasmic

1

2

High-throughput

0.445

High

1181472

EMAL3
Echinoderm microtubule-associated protein-like 3

1

4

High-throughput

0.445

High

1199024

LURA1
Leucine rich adaptor protein 1

1

1

High-throughput

0.445

High

1199025

NUDC1
NudC domain-containing protein 1

1

2

High-throughput

0.445

High

1199027

CSN4
COP9 signalosome complex subunit 4

1

3

High-throughput

0.445

High

1199032

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

9

High-throughput

0.445

High

1199033

TOLIP
Toll-interacting protein

1

1

High-throughput

0.445

High

1199034

OSBL5
Oxysterol-binding protein-related protein 5

1

3

High-throughput

0.445

High

1199037

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

9

High-throughput

0.445

High

1199048

CSN7A
COP9 signalosome complex subunit 7a

1

3

High-throughput

0.445

High

1199052

RABX5
Rab5 GDP/GTP exchange factor

1

2

High-throughput

0.445

High

1199055

CSN3
COP9 signalosome complex subunit 3

1

17

High-throughput

0.445

High

1199012

RIT1
GTP-binding protein Rit1

1

1

Small-scale

0.437

High

251091

B4GT3
Beta-1,4-galactosyltransferase 3

1

0

High-throughput

0.426

High

1199017

FBX17
F-box only protein 17

1

0

High-throughput

0.426

High

1199057

SPEF1
Sperm flagellar protein 1

1

0

High-throughput

0.426

High

616758

SDC1
Syndecan-1

1

2

High-throughput

0.407

High

1198980

LRC73
Leucine-rich repeat-containing protein 73

1

1

High-throughput

0.407

High

1199007

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

1199020

CC120
Coiled-coil domain-containing protein 120

1

2

High-throughput

0.407

High

1199023

C170L
Cep170-like protein

1

1

High-throughput

0.407

High

1199031

LRC27
Leucine-rich repeat-containing protein 27

1

3

High-throughput

0.407

High

1199030

LNP
Endoplasmic reticulum junction formation protein lunapark

5

0

Small-scale

0.375

High

641892

DRD4
D(4) dopamine receptor

5

0

Small-scale

0.370

High

1199004

RP25L
Ribonuclease P protein subunit p25-like protein

3

0

High-throughput

0.352

High

1198987

MED25
Mediator of RNA polymerase II transcription subunit 25

2

0

High-throughput

0.316

High

1198996

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1199026

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

0

High-throughput

0.316

High

1198993

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.299

High

1120851

DGCR6
Protein DGCR6

1

0

High-throughput

0.282

High

1199036

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.282

High

337174

APOM
Apolipoprotein M

1

0

High-throughput

0.232

Low

1198997

I2BP1
Interferon regulatory factor 2-binding protein 1

1

0

High-throughput

0.232

Low

1199016

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.232

Low

1199039

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.232

Low

1199042

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025