HitPredict

Interactor 1: GBRAP (O95166)
Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)
Gene: GABARAP

Interactor 2: KBTB6 (Q86V97)
Kelch repeat and BTB domain-containing protein 6
Gene: KBTBD6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.849

Property	Details
Experiments	25684205, 20562859
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	ATG8~KBTB_W-LIR
Common GO terms	GO:0005829 - cytosol GO:0035020 - regulation of Rac protein signal transduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 117 Hs			1 674
+	Hs
		891243 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		KBTB7_HUMAN (1-674): 1.98e-165: 492: 89.76
+	Hs
		306250 GBRAP_HUMAN (1-117): 8.06e-57: 173: 100.00		KBTB7_HUMAN (1-674): 1.98e-165: 492: 89.76
+	Hs
		1262066 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		KBTB7_HUMAN (1-674): 1.98e-165: 492: 89.76
+	Hs
		891206 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		KBTB6_HUMAN (1-674): 1.29e-159: 477: 100.00
+	Hs
		1201303 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		KBTB6_HUMAN (1-674): 1.29e-159: 477: 100.00
+	Hs
		1262059 MLP3C_HUMAN (5-116): 1.15e-44: 143: 38.60		KBTB7_HUMAN (1-674): 1.98e-165: 492: 89.76
+	Hs
		1262064 MLP3B_HUMAN (2-117): 3.54e-44: 141: 30.51		KBTB7_HUMAN (1-674): 1.98e-165: 492: 89.76
+	Hs
		1201299 MLP3C_HUMAN (5-116): 1.15e-44: 143: 38.60		KBTB6_HUMAN (1-674): 1.29e-159: 477: 100.00
+	Hs
		1201302 MLP3B_HUMAN (2-117): 3.54e-44: 141: 30.51		KBTB6_HUMAN (1-674): 1.29e-159: 477: 100.00
+	Hs
		891139 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		KEAP1_HUMAN (433-671): 3.47e-51: 189: 15.95
+	Hs
		306167 GBRAP_HUMAN (1-117): 8.06e-57: 173: 100.00		KEAP1_HUMAN (433-671): 3.47e-51: 189: 15.95
+	Hs
		1049326 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		KEAP1_HUMAN (433-671): 3.47e-51: 189: 15.95
+	Dm
		1181841 Q9W2S2_DROME (1-117): 5.29e-58: 176: 91.45		Q7KSF5_DROME (435-671): 1.88e-44: 172: 13.73
+	Hs
		1049329 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		KEAP1_HUMAN (433-671): 3.47e-51: 189: 15.95
+	Hs
		1049322 MLP3B_HUMAN (2-117): 3.54e-44: 141: 30.51		KEAP1_HUMAN (433-671): 3.47e-51: 189: 15.95
+	Hs
		891272 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		KLHL5_HUMAN (312-483): 4.15e-26: 116: 17.51
+	Hs
		1299556 MLP3B_HUMAN (2-117): 3.54e-44: 141: 30.51		KLHL5_HUMAN (312-483): 4.15e-26: 116: 17.51
+	Hs
		1120814 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		KLH12_HUMAN (505-667): 2.1e-22: 103: 13.30
+	Hs
		1120811 MLP3B_HUMAN (2-117): 3.54e-44: 141: 30.51		KLH12_HUMAN (505-667): 2.1e-22: 103: 13.30