Protein: AQP2
Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct)

Gene: AQP2
Organism: Homo sapiens
Interactions: 68
UniProt ID: P41181

Gene Ontology (top 5):
GO:0003091 - renal water homeostasis
GO:0003097 - renal water transport
GO:0005372 - water transmembrane transporter activity
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

832657

ERG28
Ergosterol biosynthetic protein 28 homolog

3

2

Small-scale

0.654

High

60559

TM218
Transmembrane protein 218

2

1

High-throughput

0.606

High

162170

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

2

1

High-throughput

0.606

High

590257

MUC1
Mucin-1

2

2

High-throughput

0.606

High

832617

EFNA5
Ephrin-A5

2

1

High-throughput

0.606

High

832623

PDZ1I
PDZK1-interacting protein 1

2

2

High-throughput

0.606

High

832626

SGMR2
Sigma intracellular receptor 2

2

2

High-throughput

0.606

High

832627

M4A13
Membrane-spanning 4-domains subfamily A member 13

2

1

High-throughput

0.606

High

832628

F209A
Protein FAM209A

2

2

High-throughput

0.606

High

832629

RTP2
Receptor-transporting protein 2

2

1

High-throughput

0.606

High

832634

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

2

High-throughput

0.606

High

832637

TM86A
Lysoplasmalogenase TMEM86A

2

1

High-throughput

0.606

High

832640

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

2

High-throughput

0.606

High

832641

GPX8
Probable glutathione peroxidase 8

2

2

High-throughput

0.606

High

832645

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

4

High-throughput

0.606

High

832649

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

3

High-throughput

0.606

High

832651

S26A6
Solute carrier family 26 member 6

2

2

High-throughput

0.606

High

832653

TMM60
Transmembrane protein 60

2

1

High-throughput

0.606

High

832655

S38A7
Sodium-coupled neutral amino acid transporter 7

2

6

High-throughput

0.606

High

832661

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

1

High-throughput

0.606

High

832630

SNP47
Synaptosomal-associated protein 47

2

0

High-throughput

0.580

High

832631

TM236
Transmembrane protein 236

2

0

High-throughput

0.580

High

832633

OLFM4
Olfactomedin-4

2

0

High-throughput

0.580

High

832639

O10AG
Olfactory receptor 10AG1

2

0

High-throughput

0.580

High

832647

PANX1
Pannexin-1

2

0

High-throughput

0.580

High

832650

TM109
Voltage-gated monoatomic cation channel TMEM109

2

0

High-throughput

0.580

High

230276

CREB3
Cyclic AMP-responsive element-binding protein 3

1

4

High-throughput

0.573

High

665955

IBP5
Insulin-like growth factor-binding protein 5

2

2

High-throughput

0.553

High

832632

MRM1
rRNA methyltransferase 1, mitochondrial

2

2

High-throughput

0.553

High

832646

YIPF6
Protein YIPF6

2

2

High-throughput

0.553

High

832664

INSI2
Insulin-induced gene 2 protein

2

2

High-throughput

0.553

High

63643

A5PKU2
TUSC5 protein

1

2

High-throughput

0.515

High

832621

PMP22
Peripheral myelin protein 22

1

3

High-throughput

0.515

High

832636

NRM
Nurim

1

1

High-throughput

0.515

High

832658

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.512

High

832643

FAM3C
Protein FAM3C

1

0

High-throughput

0.493

High

212555

GPAA1
GPI-anchor transamidase component GPAA1

1

1

Small-scale

0.481

High

332898

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

8

Small-scale

0.481

High

337866

CLD7
Claudin-7

1

4

Small-scale

0.481

High

528665

PPGB
Lysosomal protective protein

1

3

High-throughput

0.481

High

832622

PLP2
Proteolipid protein 2

1

4

Small-scale

0.481

High

832635

TARG1
Trafficking regulator of GLUT4 1

1

2

High-throughput

0.481

High

832648

TM9S2
Transmembrane 9 superfamily member 2

1

3

Small-scale

0.481

High

832652

CXL16
C-X-C motif chemokine 16

1

1

High-throughput

0.481

High

832656

CC167
Coiled-coil domain-containing protein 167

1

1

Small-scale

0.481

High

832659

STX8
Syntaxin-8

1

14

Small-scale

0.481

High

832663

CERT
Ceramide transfer protein

1

1

Small-scale

0.481

High

536658

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.479

High

761569

HSP74
Heat shock 70 kDa protein 4

1

4

Small-scale

0.479

High

832625

Q59EV6
Carboxypeptidase

1

3

High-throughput

0.470

High

727513

SC5A2
Sodium/glucose cotransporter 2

1

0

Small-scale

0.460

High

832614

IEX1
Radiation-inducible immediate-early gene IEX-1

1

0

Small-scale

0.460

High

832616

BAP31
B-cell receptor-associated protein 31

1

0

Small-scale

0.460

High

832619

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.460

High

832620

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.460

High

832624

CLCA4
Calcium-activated chloride channel regulator 4

1

0

High-throughput

0.460

High

832644

TM230
Transmembrane protein 230

1

0

Small-scale

0.460

High

832654

NFIP2
NEDD4 family-interacting protein 2

1

0

Small-scale

0.460

High

832665

SNX5
Sorting nexin-5

1

0

Small-scale

0.460

High

832615

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

Small-scale

0.458

High

832642

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

1

1

Small-scale

0.439

High

832662

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

10

Small-scale

0.439

High

832666

SPCS1
Signal peptidase complex subunit 1

1

2

Small-scale

0.439

High

71839

LEUTX
Paired-like homeodomain transcription factor LEUTX

2

0

High-throughput

0.316

High

832618

LIPR1
Inactive pancreatic lipase-related protein 1

2

0

High-throughput

0.316

High

137317

ELL2
RNA polymerase II elongation factor ELL2

1

0

Small-scale

0.251

Low

832638

SP20H
Transcription factor SPT20 homolog

1

0

Small-scale

0.251

Low

832660

SSRG
Translocon-associated protein subunit gamma

1

0

Small-scale

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025