HitPredict

Interactor 1: IPO7 (O95373)
Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7)
Gene: IPO7

Interactor 2: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arm~Cse1, Arm_3~Cse1, Cse1~IBB, IBB~IBN_N
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Hs			1 529
+	Xl
		193806 O42480_XENLA (1-1038): 0: 882: 92.49		Q7ZYI0_XENLA (1-529): 1.33e-153: 451: 75.47
+	Hs
		853218 XPO2_HUMAN (2-921): 1.6e-168: 521: 17.50		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Hs
		134861 XPO2_HUMAN (2-921): 1.6e-168: 521: 17.50		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Dm
		283985 XPO2_DROME (2-1002): 6.44e-157: 491: 16.99		O76521_DROME (9-529): 1.52e-145: 431: 44.71
+	Hs
		853551 XPO2_HUMAN (2-921): 1.6e-168: 521: 17.50		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		853409 TNPO1_HUMAN (12-892): 7.7e-134: 428: 13.08		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Hs
		134943 TNPO1_HUMAN (12-892): 7.7e-134: 428: 13.08		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Dm
		853816 XPO2_DROME (2-1002): 6.44e-157: 491: 16.99		IMA_DROME (6-529): 2.4e-121: 368: 48.30
+	Hs
		853287 IMB1_HUMAN (5-785): 2.49e-114: 375: 12.82		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	At
		1280912 IMB1_ARATH (1-892): 9.86e-118: 384: 12.16		IMPA1_ARATH (1-529): 3.69e-156: 457: 45.00
+	Sc
		704136 CSE1_YEAST (2-981): 1.98e-130: 421: 15.14		IMA1_YEAST (2-529): 3.96e-141: 419: 43.83
+	At
		97814 IMB1_ARATH (1-892): 9.86e-118: 384: 12.16		IMPA2_ARATH (1-529): 1.12e-155: 456: 44.47
+	Hs
		134900 IMB1_HUMAN (5-785): 2.49e-114: 375: 12.82		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Hs
		131437 IMB1_HUMAN (5-785): 2.49e-114: 375: 12.82		IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06
+	Hs
		127222 IPO5_HUMAN (4-955): 1.57e-121: 400: 11.44		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		238680 IMB1_HUMAN (5-785): 2.49e-114: 375: 12.82		IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37
+	Dm
		1359635 IPO9_DROME (4-983): 5.63e-116: 383: 14.86		Q9V455_DROME (1-529): 3.23e-136: 406: 47.55
+	Dm
		1359642 Q9VN44_DROME (4-956): 3.2e-115: 383: 13.44		Q9V455_DROME (1-529): 3.23e-136: 406: 47.55
+	Hs
		168637 IMB1_HUMAN (5-785): 2.49e-114: 375: 12.82		IMA6_HUMAN (1-528): 9.99e-138: 410: 45.02
+	Hs
		69189 IMB1_HUMAN (5-785): 2.49e-114: 375: 12.82		IMA8_HUMAN (4-517): 2.56e-125: 378: 54.28