Protein: MTX2
Metaxin-2 (Mitochondrial outer membrane import complex protein 2)

Gene: MTX2
Organism: Homo sapiens
Interactions: 168
UniProt ID: O75431

Gene Ontology (top 5):
GO:0001401 - SAM complex
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

281696

SAM50
Sorting and assembly machinery component 50 homolog

6

4

Small-scale

0.952

High

281600

MTX3
Metaxin-3

3

8

High-throughput

0.861

High

281601

FAXC
Failed axon connections homolog

2

8

High-throughput

0.776

High

281597

MIC60
MICOS complex subunit MIC60

6

3

Small-scale

0.730

High

281650

MIC25
MICOS complex subunit MIC25

5

4

High-throughput

0.716

High

281682

MIC19
MICOS complex subunit MIC19

4

4

High-throughput

0.699

High

281569

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

3

High-throughput

0.691

High

281642

CAR19
Caspase recruitment domain-containing protein 19

3

1

High-throughput

0.662

High

281690

TRAK1
Trafficking kinesin-binding protein 1

3

4

High-throughput

0.650

High

281656

CD244
Natural killer cell receptor 2B4

4

2

High-throughput

0.630

High

281587

MTX1
Metaxin-1

1

8

Small-scale

0.618

High

244828

TRAK2
Trafficking kinesin-binding protein 2

2

5

High-throughput

0.611

High

281606

MIC27
MICOS complex subunit MIC27

2

4

High-throughput

0.611

High

281679

DJC11
DnaJ homolog subfamily C member 11

2

4

High-throughput

0.611

High

281687

UBQL2
Ubiquilin-2

2

2

High-throughput

0.606

High

281586

SQSTM
Sequestosome-1

2

2

Small-scale

0.584

High

281630

AKAP1
A-kinase anchor protein 1, mitochondrial

2

4

High-throughput

0.584

High

281594

RHOH
Rho-related GTP-binding protein RhoH

2

0

High-throughput

0.580

High

177350

ARHGB
Rho guanine nucleotide exchange factor 11

2

2

High-throughput

0.571

High

281698

MTCH2
Mitochondrial carrier homolog 2

2

6

High-throughput

0.571

High

281558

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

281653

C1QT2
Complement C1q tumor necrosis factor-related protein 2

2

1

High-throughput

0.553

High

281554

ESR1
Estrogen receptor

1

2

High-throughput

0.536

High

281562

EDNRA
Endothelin-1 receptor

1

8

High-throughput

0.536

High

281563

DNJB1
DnaJ homolog subfamily B member 1

1

1

High-throughput

0.536

High

281565

1433T
14-3-3 protein theta

1

1

High-throughput

0.536

High

281567

PHB1
Prohibitin 1

1

4

High-throughput

0.536

High

281579

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.536

High

281620

CE120
Centrosomal protein of 120 kDa

1

1

High-throughput

0.536

High

281626

HUMMR
Protein MGARP

1

1

High-throughput

0.536

High

281647

PHB2
Prohibitin-2

1

4

High-throughput

0.536

High

281670

PARVG
Gamma-parvin

1

3

High-throughput

0.536

High

281689

EI2BD
Translation initiation factor eIF2B subunit delta

1

1

High-throughput

0.536

High

137160

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.513

High

281577

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.513

High

281578

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.513

High

281588

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.513

High

281637

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

165873

FFAR1
Free fatty acid receptor 1

1

8

High-throughput

0.489

High

281557

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

2

High-throughput

0.489

High

281595

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.489

High

281607

T184A
Transmembrane protein 184A

1

1

High-throughput

0.489

High

281612

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

9

High-throughput

0.489

High

281618

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

1

High-throughput

0.489

High

281683

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

2

High-throughput

0.489

High

192148

YKT6
Synaptobrevin homolog YKT6

1

2

High-throughput

0.479

High

215225

TXNL1
Thioredoxin-like protein 1

1

2

High-throughput

0.479

High

216586

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

239346

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

1

High-throughput

0.479

High

245391

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

2

High-throughput

0.479

High

258681

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.479

High

281550

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.479

High

281551

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.479

High

281553

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

4

High-throughput

0.479

High

281560

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

281574

TPD52
Tumor protein D52

1

1

High-throughput

0.479

High

281575

GEMI4
Gem-associated protein 4

1

1

High-throughput

0.479

High

281584

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

1

1

High-throughput

0.479

High

281585

PHLP
Phosducin-like protein

1

1

High-throughput

0.479

High

281590

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

3

High-throughput

0.479

High

281591

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

281593

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

281596

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.479

High

281602

MIC10
MICOS complex subunit MIC10

1

1

Small-scale

0.479

High

281603

VP13D
Intermembrane lipid transfer protein VPS13D

1

1

High-throughput

0.479

High

281604

MIC13
MICOS complex subunit MIC13

1

1

High-throughput

0.479

High

281608

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

2

High-throughput

0.479

High

281616

MIRO2
Mitochondrial Rho GTPase 2

1

2

High-throughput

0.479

High

281617

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

281631

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

281632

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

Small-scale

0.479

High

281634

OPTN
Optineurin

1

2

High-throughput

0.479

High

281635

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

1

High-throughput

0.479

High

281639

COX14
Cytochrome c oxidase assembly protein COX14

1

1

High-throughput

0.479

High

281640

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

1

High-throughput

0.479

High

281641

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

281645

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

281652

MIC26
MICOS complex subunit MIC26

1

4

High-throughput

0.479

High

281662

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

2

High-throughput

0.479

High

281663

PDCL3
Phosducin-like protein 3

1

1

High-throughput

0.479

High

281665

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

281667

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

281668

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

281669

SFXN1
Sideroflexin-1

1

2

High-throughput

0.479

High

281671

PLRKT
Plasminogen receptor

1

1

High-throughput

0.479

High

281675

DBLOH
Diablo IAP-binding mitochondrial protein

1

2

High-throughput

0.479

High

281677

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

2

High-throughput

0.479

High

281681

OCAD1
OCIA domain-containing protein 1

1

2

High-throughput

0.479

High

281684

MTCH1
Mitochondrial carrier homolog 1

1

4

High-throughput

0.479

High

281688

DDX20
Probable ATP-dependent RNA helicase DDX20

1

2

High-throughput

0.479

High

281694

TDRKH
Tudor and KH domain-containing protein

1

3

High-throughput

0.479

High

281695

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

281548

EED
Polycomb protein EED

1

1

High-throughput

0.470

High

133716

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

135423

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.458

High

137581

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

222578

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

258216

TRI13
E3 ubiquitin-protein ligase TRIM13

1

0

High-throughput

0.458

High

281552

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

281556

ACM2
Muscarinic acetylcholine receptor M2

1

0

High-throughput

0.458

High

281561

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

281571

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

281572

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

281581

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

281592

MTFR1
Mitochondrial fission regulator 1

1

0

High-throughput

0.458

High

281610

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

281611

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.458

High

281613

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.458

High

281614

LRC49
Leucine-rich repeat-containing protein 49

1

0

High-throughput

0.458

High

281621

MIGA1
Mitoguardin 1

1

0

High-throughput

0.458

High

281638

MYO19
Unconventional myosin-XIX

1

0

High-throughput

0.458

High

281646

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.458

High

281651

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.458

High

281658

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.458

High

281659

MFF
Mitochondrial fission factor

1

0

High-throughput

0.458

High

281660

CLPB
Mitochondrial disaggregase

1

0

High-throughput

0.458

High

281664

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

281666

TRABD
TraB domain-containing protein

1

0

High-throughput

0.458

High

281678

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

281680

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

281685

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

0

High-throughput

0.458

High

281686

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

281697

RBM8A
RNA-binding protein 8A

1

0

High-throughput

0.458

High

281629

LPAR1
Lysophosphatidic acid receptor 1

1

6

High-throughput

0.445

High

281644

PCFT
Proton-coupled folate transporter

1

3

High-throughput

0.445

High

281676

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

156766

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

281559

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

281566

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

281568

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

281605

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

281609

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

281633

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.437

High

281648

AKAP9
A-kinase anchor protein 9

1

3

High-throughput

0.437

High

281657

ASXL3
Putative Polycomb group protein ASXL3

1

2

High-throughput

0.437

High

281672

MOV10
Helicase MOV-10

1

1

High-throughput

0.437

High

281673

DNJC4
DnaJ homolog subfamily C member 4

1

2

High-throughput

0.437

High

281691

SRRM2
Serine/arginine repetitive matrix protein 2

1

1

High-throughput

0.437

High

281549

XRP2
Protein XRP2

1

0

High-throughput

0.426

High

281615

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.426

High

281649

TBA1C
Tubulin alpha-1C chain

1

0

High-throughput

0.426

High

281599

ATG2A
Autophagy-related protein 2 homolog A

1

1

Small-scale

0.407

High

281624

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.407

High

281654

S12A9
Solute carrier family 12 member 9

1

1

High-throughput

0.407

High

281661

S35B3
Adenosine 3'-phospho 5'-phosphosulfate transporter 2

1

1

High-throughput

0.407

High

281619

KASH5
Protein KASH5

3

0

High-throughput

0.352

High

281547

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.299

High

281576

FAM3B
Protein FAM3B

1

0

High-throughput

0.279

Low

281582

COAA1

1

0

High-throughput

0.279

Low

281589

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

281598

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.279

Low

281623

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.279

Low

281625

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

281564

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.249

Low

281573

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.249

Low

281580

TRA2B
Transformer-2 protein homolog beta

1

0

High-throughput

0.249

Low

281583

SRSF4
Serine/arginine-rich splicing factor 4

1

0

High-throughput

0.249

Low

281628

UBXN4
UBX domain-containing protein 4

1

0

High-throughput

0.249

Low

281643

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low

281655

RNF26
E3 ubiquitin-protein ligase RNF26

1

0

High-throughput

0.249

Low

281674

ANLN
Anillin

1

0

High-throughput

0.249

Low

281555

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

281570

KPB1
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform

1

0

High-throughput

0.232

Low

281622

XXLT1
Xyloside xylosyltransferase 1

1

0

High-throughput

0.232

Low

281627

CTR3
Cationic amino acid transporter 3

1

0

High-throughput

0.232

Low

281636

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low

281692

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low

281693

KLDC2
Kelch domain-containing protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025