HitPredict

Interactor 1: SVIL (O95425)
Supervillin (Archvillin) (p205/p250)
Gene: SVIL

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	11792840, 33731348
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 2214 Hs			1 595
+	Hs
		313722 SVIL_HUMAN (1-2214): 0: 3444: 100.00		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Hs
		313768 SVIL_HUMAN (1-2214): 0: 3444: 100.00		PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35
+	Hs
		313734 SVIL_HUMAN (1-2214): 0: 3444: 100.00		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		368817 GELS_HUMAN (1714-2122): 2.55e-82: 291: 18.25		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		414017 GELS_HUMAN (1714-2122): 2.55e-82: 291: 18.25		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		369509 FLII_HUMAN (1423-1683): 1.3e-16: 88.8: 17.30		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		1270065 SCIN_HUMAN (1754-2197): 1.42e-75: 269: 19.65		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		93996 GELS_HUMAN (1714-2122): 2.55e-82: 291: 18.25		F1D8P7_HUMAN (103-548): 1.37e-102: 320: 21.43
+	Hs
		377027 VILI_HUMAN (1747-2125): 7.86e-57: 215: 20.21		GCR_HUMAN (5-557): 4.67e-109: 346: 22.51
+	Hs
		1023211 FLII_HUMAN (1423-1683): 1.3e-16: 88.8: 17.30		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		413810 GELS_HUMAN (1714-2122): 2.55e-82: 291: 18.25		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		487386 FLII_HUMAN (1423-1683): 1.3e-16: 88.8: 17.30		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16