HitPredict

Interactor 1: CBX6 (O95503)
Chromobox protein homolog 6
Gene: CBX6

Interactor 2: PHC2 (Q8IXK0)
Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)
Gene: PHC2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.722

Property	Details
Experiments	27705803, 24981860, 22325352, 33961781, 21282530
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000792 - heterochromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 858
+	Hs
		1220894 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00
+	Hs
		316005 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40
+	Hs
		69543 B0QXZ6_HUMAN (1-393): 3.76e-108: 325: 95.42		PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40
+	Hs
		327853 CBX7_HUMAN (1-207): 2.43e-45: 159: 33.33		PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00
+	Hs
		316124 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		SCMH1_HUMAN (439-857): 3.7e-30: 129: 18.18
+	Hs
		316204 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		SCML2_HUMAN (449-857): 3.15e-29: 126: 16.30
+	Hs
		203732 SUV91_HUMAN (11-222): 8.35e-36: 137: 17.21		PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00
+	Hs
		123280 CBX4_HUMAN (1-362): 3.71e-34: 135: 23.28		PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00
+	Hs
		316103 CBX6_HUMAN (1-393): 1.39e-116: 347: 100.00		PHC3_HUMAN (12-763): 3.91e-14: 78.9: 23.81
+	Dr
		1193375 Q804D1_DANRE (1-385): 1.19e-77: 250: 24.21		PHC2_DANRE (8-858): 4.13e-43: 170: 39.21
+	Hs
		943094 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40
+	Hs
		1292155 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		SCMH1_HUMAN (439-857): 3.7e-30: 129: 18.18
+	Hs
		1335794 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		SCML2_HUMAN (449-857): 3.15e-29: 126: 16.30
+	Hs
		327838 CBX7_HUMAN (1-207): 2.43e-45: 159: 33.33		PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40
+	Dm
		639953 PC_DROME (10-393): 7.49e-58: 196: 21.04		PHP_DROME (266-857): 1.2e-30: 132: 21.96
+	Dm
		639970 PC_DROME (10-393): 7.49e-58: 196: 21.04		Q9NF31_DROME (234-857): 1.54e-29: 128: 21.24
+	Hs
		1242737 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		PHC3_HUMAN (12-763): 3.91e-14: 78.9: 23.81
+	Dm
		639977 PC_DROME (10-393): 7.49e-58: 196: 21.04		SCM_DROME (385-855): 4.95e-26: 116: 13.74
+	Hs
		123234 CBX4_HUMAN (1-362): 3.71e-34: 135: 23.28		PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40
+	Hs
		327855 CBX7_HUMAN (1-207): 2.43e-45: 159: 33.33		PHC3_HUMAN (12-763): 3.91e-14: 78.9: 23.81