HitPredict

Interactor 1: MTA2 (O94776)
Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)
Gene: MTA2

Interactor 2: P66B (Q8WXI9)
Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)
Gene: GATAD2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.961

The method score is based on:

Property	Details
Experiments	26186194, 28514442, 11756549, 24981860, 33961781, 40437099, 26816381
Identification Methods	affinity chromatography technology, cross-linking study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	GATA~GATA
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000781 - chromosome, telomeric region GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm and 9 others more... GO:0006338 - chromatin remodeling GO:0008270 - zinc ion binding GO:0016581 - NuRD complex GO:0032991 - protein-containing complex GO:0042659 - regulation of cell fate specification GO:0043565 - sequence-specific DNA binding GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:2000736 - regulation of stem cell differentiation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	668
Hs

1	593

Service provided by Combinatics, Japan

Last updated: 11Aug2025