Protein: P66A
Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A)

Gene: P66A, GATAD2A
Organism: Homo sapiens
Interactions: 210
UniProt ID: Q86YP4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006338 - chromatin remodeling
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1295318

MBD2
Methyl-CpG-binding domain protein 2

13

7

Small-scale

0.982

High

352178

MBD3
Methyl-CpG-binding domain protein 3

10

7

Small-scale

0.973

High

1295273

MB3L1
Methyl-CpG-binding domain protein 3-like 1

5

7

High-throughput

0.926

High

316906

MTA2
Metastasis-associated protein MTA2

5

6

Small-scale

0.922

High

1102586

MTA1
Metastasis-associated protein MTA1

5

6

Small-scale

0.919

High

1295296

MTA3
Metastasis-associated protein MTA3

4

6

High-throughput

0.903

High

1295322

TRPS1
Zinc finger transcription factor Trps1

2

10

High-throughput

0.776

High

1109865

HDAC1
Histone deacetylase 1

11

4

Small-scale

0.759

High

1066377

RBBP4
Histone-binding protein RBBP4

8

5

Small-scale

0.752

High

1158906

RBBP7
Histone-binding protein RBBP7

8

5

Small-scale

0.751

High

1295278

HDAC2
Histone deacetylase 2

8

4

Small-scale

0.750

High

1132807

CHD4
Chromodomain-helicase-DNA-binding protein 4

8

13

Small-scale

0.749

High

155320

CDKA1
Cyclin-dependent kinase 2-associated protein 1

7

3

Small-scale

0.744

High

1295327

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

5

7

Small-scale

0.718

High

1295274

P66B
Transcriptional repressor p66-beta

2

0

High-throughput

0.716

High

998505

H31
Histone H3.1

5

5

Small-scale

0.704

High

1088431

CHD3
Chromodomain-helicase-DNA-binding protein 3

4

13

High-throughput

0.699

High

1295269

MB3L2
Methyl-CpG-binding domain protein 3-like 2

1

7

High-throughput

0.691

High

1295263

ZN687
Zinc finger protein 687

3

1

High-throughput

0.675

High

960478

PSME3
Proteasome activator complex subunit 3

3

1

High-throughput

0.667

High

997833

CSK21
Casein kinase II subunit alpha

3

5

High-throughput

0.667

High

1289772

ZBT46
Zinc finger and BTB domain-containing protein 46

3

7

High-throughput

0.667

High

1295270

CHD5
Chromodomain-helicase-DNA-binding protein 5

3

13

Small-scale

0.667

High

1295317

ZN219
Zinc finger protein 219

3

1

High-throughput

0.667

High

911295

IMA5
Importin subunit alpha-5

3

5

High-throughput

0.662

High

1295287

Z512B
Zinc finger protein 512B

3

2

High-throughput

0.650

High

1295275

ZN592
Zinc finger protein 592

2

1

High-throughput

0.628

High

1163035

H2B2E
Histone H2B type 2-E

2

4

Small-scale

0.619

High

851603

GATA4
Transcription factor GATA-4

1

4

High-throughput

0.618

High

71454

P20L1
PHD finger protein 20-like protein 1

2

1

High-throughput

0.611

High

502044

H2AZ
Histone H2A.Z

2

5

High-throughput

0.611

High

625476

CSK22
Casein kinase II subunit alpha'

2

5

High-throughput

0.611

High

872496

SOX2
Transcription factor SOX-2

2

11

High-throughput

0.611

High

1040844

MECOM
Histone-lysine N-methyltransferase MECOM

2

4

High-throughput

0.611

High

1104606

IKZF1
DNA-binding protein Ikaros

2

3

High-throughput

0.611

High

1295311

SALL1
Sal-like protein 1

2

6

High-throughput

0.611

High

1295258

F219A
Protein FAM219A

3

1

High-throughput

0.609

High

831019

CCNF
Cyclin-F

2

1

High-throughput

0.601

High

910977

IMA1
Importin subunit alpha-1

2

5

High-throughput

0.601

High

979934

H4
Histone H4

2

1

Small-scale

0.595

High

260145

BRD4
Bromodomain-containing protein 4

2

10

High-throughput

0.584

High

372484

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

1137381

SUZ12
Polycomb protein SUZ12

2

1

High-throughput

0.584

High

1141202

BRD3
Bromodomain-containing protein 3

2

9

High-throughput

0.584

High

1155521

EZH2
Histone-lysine N-methyltransferase EZH2

2

2

High-throughput

0.584

High

300409

KRT34
Keratin, type I cuticular Ha4

2

2

High-throughput

0.553

High

1127791

K1H2
Keratin, type I cuticular Ha2

2

2

High-throughput

0.553

High

1295282

STMN2
Stathmin-2

2

1

High-throughput

0.549

High

487494

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.536

High

542571

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

1034111

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

1

1

High-throughput

0.536

High

1065283

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.536

High

1165245

ZN827
Zinc finger protein 827

1

4

Small-scale

0.536

High

1295277

THRSP
Thyroid hormone-inducible hepatic protein

1

1

High-throughput

0.536

High

1295299

BC11B
B-cell lymphoma/leukemia 11B

1

3

High-throughput

0.536

High

1295309

HM20A
High mobility group protein 20A

1

10

High-throughput

0.536

High

1295320

TCF20
Transcription factor 20

1

2

High-throughput

0.536

High

1295323

SALL4
Sal-like protein 4

1

6

High-throughput

0.536

High

887005

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.527

High

1230120

K1C40
Keratin, type I cytoskeletal 40

1

2

High-throughput

0.523

High

1133511

NFIX
Nuclear factor 1 X-type

1

7

High-throughput

0.515

High

334049

SMC2
Structural maintenance of chromosomes protein 2

1

0

High-throughput

0.513

High

440621

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.513

High

484590

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1054738

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.513

High

1213116

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.513

High

1287367

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

0

High-throughput

0.513

High

1295260

SUGP1
SURP and G-patch domain-containing protein 1

1

0

High-throughput

0.513

High

1295276

APBP2
Amyloid protein-binding protein 2

1

0

High-throughput

0.513

High

1295283

INT12
Integrator complex subunit 12

1

0

High-throughput

0.513

High

1295289

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.513

High

1295291

CCNL2
Cyclin-L2

1

0

High-throughput

0.513

High

1295295

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.513

High

1162821

H2A2C
Histone H2A type 2-C

1

3

Small-scale

0.501

High

1295308

CPNE5
Copine-5

1

1

High-throughput

0.489

High

1295280

CBP
CREB-binding protein

1

6

Small-scale

0.481

High

129236

MEN1
Menin

1

1

High-throughput

0.479

High

143099

NFIB
Nuclear factor 1 B-type

1

7

High-throughput

0.479

High

168285

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.479

High

190983

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

194257

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

210308

PHF1
PHD finger protein 1

1

3

High-throughput

0.479

High

242188

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

243670

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

13

High-throughput

0.479

High

274350

SIN3B
Paired amphipathic helix protein Sin3b

1

5

High-throughput

0.479

High

277733

H2AY
Core histone macro-H2A.1

1

5

High-throughput

0.479

High

282270

SAP30
Histone deacetylase complex subunit SAP30

1

1

High-throughput

0.479

High

285350

EED
Polycomb protein EED

1

3

High-throughput

0.479

High

299480

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

3

Small-scale

0.479

High

315750

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

324969

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

334567

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

7

Small-scale

0.479

High

401093

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

404190

GCR
Glucocorticoid receptor

1

6

High-throughput

0.479

High

414146

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

474107

NFIC
Nuclear factor 1 C-type

1

7

High-throughput

0.479

High

519523

MYBB
Myb-related protein B

1

2

High-throughput

0.479

High

589084

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

591720

H2AX
Histone H2AX

1

5

High-throughput

0.479

High

606895

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

636109

CD11B
Cyclin-dependent kinase 11B

1

1

High-throughput

0.479

High

674230

BRD2
Bromodomain-containing protein 2

1

7

High-throughput

0.479

High

695869

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

703344

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

13

High-throughput

0.479

High

714243

PML
Protein PML

1

1

High-throughput

0.479

High

754902

H2B1B
Histone H2B type 1-B

1

4

High-throughput

0.479

High

768584

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

776098

SOX5
Transcription factor SOX-5

1

12

High-throughput

0.479

High

776215

SOX6
Transcription factor SOX-6

1

15

High-throughput

0.479

High

855467

ATRX
Transcriptional regulator ATRX

1

14

Small-scale

0.479

High

879246

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

883601

CENPA
Histone H3-like centromeric protein A

1

5

High-throughput

0.479

High

941482

CTBP2
C-terminal-binding protein 2

1

2

High-throughput

0.479

High

944696

KLF3
Krueppel-like factor 3

1

4

High-throughput

0.479

High

980901

H2B1C
Histone H2B type 1-C/E/F/G/I

1

4

High-throughput

0.479

High

995119

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.479

High

1016998

H33
Histone H3.3

1

5

High-throughput

0.479

High

1029872

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

1042889

ERCC6
DNA excision repair protein ERCC-6

1

15

Small-scale

0.479

High

1086787

BPTF
Nucleosome-remodeling factor subunit BPTF

1

14

High-throughput

0.479

High

1087850

NFIA
Nuclear factor 1 A-type

1

7

High-throughput

0.479

High

1094701

CAF1A
Chromatin assembly factor 1 subunit A

1

2

High-throughput

0.479

High

1094783

CAF1B
Chromatin assembly factor 1 subunit B

1

2

High-throughput

0.479

High

1103261

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.479

High

1106350

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

2

High-throughput

0.479

High

1135255

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

15

High-throughput

0.479

High

1145488

RBBP5
Retinoblastoma-binding protein 5

1

2

High-throughput

0.479

High

1195564

ARI4B
AT-rich interactive domain-containing protein 4B

1

3

High-throughput

0.479

High

1197993

LIN52
Protein lin-52 homolog

1

1

High-throughput

0.479

High

1208612

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

3

High-throughput

0.479

High

1216607

LIN9
Protein lin-9 homolog

1

1

High-throughput

0.479

High

1254497

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1276444

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1294534

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

1

Small-scale

0.479

High

1295261

BAP18
BPTF-associated chromatin complex component 1

1

1

High-throughput

0.479

High

1295262

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

1295264

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

2

High-throughput

0.479

High

1295265

HJURP
Holliday junction recognition protein

1

1

High-throughput

0.479

High

1295266

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

3

Small-scale

0.479

High

1295267

CSK23
Casein kinase II subunit alpha 3

1

5

High-throughput

0.479

High

1295268

NUP43
Nucleoporin Nup43

1

7

High-throughput

0.479

High

1295272

GATD1
GATA zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

1295279

REQU
Zinc finger protein ubi-d4

1

8

High-throughput

0.479

High

1295281

KAT2B
Histone acetyltransferase KAT2B

1

9

Small-scale

0.479

High

1295284

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

3

High-throughput

0.479

High

1295285

LIN37
Protein lin-37 homolog

1

1

High-throughput

0.479

High

1295288

PWP2A
PWWP domain-containing protein 2A

1

1

High-throughput

0.479

High

1295290

CIC
Protein capicua homolog

1

10

High-throughput

0.479

High

1295292

SIN3A
Paired amphipathic helix protein Sin3a

1

5

High-throughput

0.479

High

1295294

TBX5
T-box transcription factor TBX5

1

3

High-throughput

0.479

High

1295298

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.479

High

1295302

SP130
Histone deacetylase complex subunit SAP130

1

4

High-throughput

0.479

High

1295303

BC11A
BCL11 transcription factor A

1

3

High-throughput

0.479

High

1295306

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

3

High-throughput

0.479

High

1295307

PRD16
Histone-lysine N-methyltransferase PRDM16

1

4

High-throughput

0.479

High

1295313

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1295314

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1295316

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

13

High-throughput

0.479

High

1295319

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1295324

IKZF3
Zinc finger protein Aiolos

1

3

High-throughput

0.479

High

1295328

CD11A
Cyclin-dependent kinase 11A

1

1

High-throughput

0.479

High

1295329

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

1295331

MTF2
Metal-response element-binding transcription factor 2

1

3

High-throughput

0.479

High

1295332

KLF12
Krueppel-like factor 12

1

2

High-throughput

0.479

High

1063396

GOGA2
Golgin subfamily A member 2

1

2

High-throughput

0.470

High

227605

SPOP
Speckle-type POZ protein

1

0

Small-scale

0.460

High

270259

MTG16
Protein CBFA2T3

1

0

High-throughput

0.460

High

447187

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

468563

HS90B
Heat shock protein HSP 90-beta

1

0

High-throughput

0.458

High

558250

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

700682

PSA5
Proteasome subunit alpha type-5

1

0

Small-scale

0.458

High

986543

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1024679

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1026451

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1138370

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1271722

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1291043

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

Small-scale

0.458

High

1295271

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1295297

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1295301

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1295310

ANLN
Anillin

1

0

High-throughput

0.458

High

1295312

NLE1
Notchless protein homolog 1

1

0

High-throughput

0.458

High

1295325

AGO2
Protein argonaute-2

1

0

High-throughput

0.458

High

1295330

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

430103

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

1111087

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.445

High

1209353

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1295293

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.445

High

1295315

GRHL1
Grainyhead-like protein 1 homolog

1

4

High-throughput

0.445

High

995677

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.437

High

1227003

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.437

High

1295304

FBX44
F-box only protein 44

1

1

Small-scale

0.437

High

1295305

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

1295321

HMGX4
HMG domain-containing protein 4

1

12

High-throughput

0.437

High

1295333

LAMC3
Laminin subunit gamma-3

1

1

High-throughput

0.437

High

344237

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

1155074

UT2
Urea transporter 2

1

1

High-throughput

0.407

High

660667

IF4B
Eukaryotic translation initiation factor 4B

2

0

High-throughput

0.313

High

1295259

ARHGJ
Rho guanine nucleotide exchange factor 19

2

0

High-throughput

0.298

High

239117

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.279

Low

375686

RASK
GTPase KRas

1

0

High-throughput

0.279

Low

549631

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

867803

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

High-throughput

0.279

Low

1295286

BT3L4
Transcription factor BTF3 homolog 4

1

0

High-throughput

0.279

Low

272298

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

299271

FLOT1
Flotillin-1

1

0

High-throughput

0.249

Low

1193701

C2CD3
C2 domain-containing protein 3

1

0

High-throughput

0.249

Low

1295300

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.249

Low

1295326

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

354732

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025