HitPredict

Interactor 1: NET1 (O95631)
Netrin-1 (Epididymis tissue protein Li 131P)
Gene: NTN1

Interactor 2: UNC5B (Q8IZJ1)
Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1)
Gene: UNC5B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	18719102, 26190107
Identification Methods	anti bait coimmunoprecipitation, avexis
Interaction Type	physical association

Property	Details
Interacting Pfam domains	NTR~TSP_1
Common GO terms	GO:0006915 - apoptotic process GO:0033564 - anterior/posterior axon guidance
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 604 Hs			1 945
+	Mm
		140335 NET1_MOUSE (1-604): 9.69e-170: 497: 99.17		UNC5B_MOUSE (1-945): 0: 944: 92.38
+	Mm
		139747 NET1_MOUSE (1-604): 9.69e-170: 497: 99.17		UNC5C_MOUSE (32-944): 0: 873: 64.95
+	Hs
		306897 NET1_HUMAN (1-604): 7.23e-170: 498: 100.00		UNC5C_HUMAN (32-944): 0: 864: 63.75
+	Dr
		69123 O42140_DANRE (2-604): 1.34e-173: 507: 86.73		A9JR35_DANRE (32-945): 0: 833: 67.50
+	Mm
		140336 NET1_MOUSE (1-604): 9.69e-170: 497: 99.17		UNC5A_MOUSE (1-945): 0: 821: 51.95
+	Mm
		140334 NET1_MOUSE (1-604): 9.69e-170: 497: 99.17		UNC5D_MOUSE (48-944): 0: 795: 53.66
+	Hs
		317791 NET1_HUMAN (1-604): 7.23e-170: 498: 100.00		UNC5A_HUMAN (1-945): 0: 733: 45.20
+	Hs
		434645 LAMB3_HUMAN (44-589): 3.63e-105: 345: 25.21		TSP1_HUMAN (171-467): 9.32e-56: 212: 23.05
+	Dm
		1098870 NETB_DROME (32-254): 2.08e-49: 185: 54.08		Q9VQ08_DROME (2-292): 2.77e-32: 138: 16.83
+	Dm
		1099064 NETB_DROME (32-254): 2.08e-49: 185: 54.08		Q9W213_DROME (149-733): 4.52e-14: 78.9: 10.38