HitPredict

Interactor 1: VATG2 (O95670)
V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (V-ATPase 13 kDa subunit 2) (Vacuolar proton pump subunit G 2)
Gene: ATP6V1G2

Interactor 2: VATE2 (Q96A05)
V-type proton ATPase subunit E 2 (V-ATPase subunit E 2) (Vacuolar proton pump subunit E 2)
Gene: ATP6V1E2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	32296183, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	V-ATPase_G~vATP-synt_E
Common GO terms	GO:0005829 - cytosol GO:0016241 - regulation of macroautophagy GO:0046961 - proton-transporting ATPase activity, rotational mechanism
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 118 Hs			1 226
+	Hs
		260063 VATG1_HUMAN (1-118): 1.67e-31: 109: 63.56		VATE1_HUMAN (1-225): 3.66e-98: 286: 76.89
+	Hs
		318278 VATG2_HUMAN (1-118): 1.31e-30: 107: 100.00		VATE1_HUMAN (1-225): 3.66e-98: 286: 76.89
+	Dm
		870988 VATG_DROME (1-114): 1.71e-30: 106: 49.12		VATE_DROME (1-224): 4.6e-94: 276: 61.16
+	Ce
		954341 VATG_CAEEL (1-113): 2.91e-26: 96.4: 50.44		VATE_CAEEL (1-225): 1.25e-96: 282: 56.00
+	Hs
		260091 VATG1_HUMAN (1-118): 1.67e-31: 109: 63.56		VATE2_HUMAN (1-226): 5.41e-90: 266: 100.00
+	Sc
		605453 VATG_YEAST (3-113): 3.05e-23: 88.3: 32.43		VATE_YEAST (2-225): 2.38e-76: 231: 35.40