HitPredict

Interactor 1: BRD1 (O95696)
Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2)
Gene: BRD1

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1058 Hs			1 126
+	Hs
		319121 BRD1_HUMAN (1-1058): 0: 1027: 100.00		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		319162 BRD1_HUMAN (1-1058): 0: 1027: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		617938 BRPF1_HUMAN (2-1058): 0: 834: 50.04		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		876685 BRPF1_HUMAN (2-1058): 0: 834: 50.04		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		876694 BRPF1_HUMAN (2-1058): 0: 834: 50.04		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		617953 JADE1_HUMAN (110-894): 5.55e-121: 393: 22.78		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		1087195 JADE1_HUMAN (110-894): 5.55e-121: 393: 22.78		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Sc
		356046 NTO1_YEAST (58-613): 9.77e-113: 368: 25.47		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355691 NTO1_YEAST (58-613): 9.77e-113: 368: 25.47		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Hs
		617963 JADE3_HUMAN (110-590): 6.17e-90: 308: 29.03		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		1087304 JADE3_HUMAN (110-590): 6.17e-90: 308: 29.03		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918569 JADE3_HUMAN (110-590): 6.17e-90: 308: 29.03		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		617982 JADE2_HUMAN (110-875): 6.63e-87: 299: 23.23		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		876570 AF10_HUMAN (217-932): 1.05e-72: 263: 18.87		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		617986 BRPF3_HUMAN (667-1055): 2.04e-69: 255: 34.78		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		1087475 BRPF3_HUMAN (667-1055): 2.04e-69: 255: 34.78		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1087293 PHIP_HUMAN (348-939): 3.6e-54: 209: 13.41		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918554 PHIP_HUMAN (348-939): 3.6e-54: 209: 13.41		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		299044 PHF14_HUMAN (173-572): 2.71e-54: 207: 17.83		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		299040 PHF14_HUMAN (173-572): 2.71e-54: 207: 17.83		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41