HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25476789, 36244648
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4834 Hs			1 648
+	Hs
		319698 HERC2_HUMAN (1-4834): 0: 6206: 100.00		ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28
+	Hs
		374703 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Hs
		373858 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Hs
		374717 NED4L_HUMAN (4321-4795): 3.82e-167: 547: 19.84		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Mm
		1208288 NED4L_MOUSE (4321-4795): 7.11e-167: 547: 19.84		RAF1_MOUSE (1-648): 0: 647: 97.69
+	Hs
		125075 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Hs
		374454 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Hs
		542908 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88
+	Hs
		488778 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28
+	Hs
		542909 NED4L_HUMAN (4321-4795): 3.82e-167: 547: 19.84		BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88
+	Hs
		125134 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88
+	Hs
		542914 WWP1_HUMAN (4323-4794): 3.33e-165: 539: 20.88		BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88
+	Hs
		542919 SMUF2_HUMAN (4316-4794): 1.68e-158: 513: 22.11		BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88
+	Hs
		1217973 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61
+	Hs
		522850 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		SRC_HUMAN (331-607): 3.01e-106: 333: 33.45
+	Hs
		433282 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		YES_HUMAN (329-607): 1.22e-105: 332: 33.92
+	Hs
		412307 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		FYN_HUMAN (337-607): 2.33e-103: 326: 34.55
+	Hs
		412081 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		FYN_HUMAN (337-607): 2.33e-103: 326: 34.55
+	Hs
		374554 RCBT1_HUMAN (425-630): 1.33e-14: 82.4: 28.70		RAF1_HUMAN (1-648): 0: 652: 100.00
+	Hs
		307239 RCBT2_HUMAN (603-769): 1.98e-16: 88.6: 35.47		YES_HUMAN (329-607): 1.22e-105: 332: 33.92