Protein: SYLC
Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS)

Gene: SYLC, LARS1
Organism: Homo sapiens
Interactions: 223
UniProt ID: Q9P2J5

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA editing activity
GO:0004819 - glutamine-tRNA ligase activity
GO:0004823 - leucine-tRNA ligase activity
GO:0005096 - GTPase activator activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

783127

SYIC
Isoleucine--tRNA ligase, cytoplasmic

5

4

Small-scale

0.922

High

880186

SYMC
Methionine--tRNA ligase, cytoplasmic

3

12

High-throughput

0.861

High

867780

SYRC
Arginine--tRNA ligase, cytoplasmic

4

2

Small-scale

0.705

High

431058

SYEP
Bifunctional glutamate/proline--tRNA ligase

4

15

Small-scale

0.694

High

1026373

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

4

1

Small-scale

0.686

High

133050

SDCB1
Syntenin-1

3

1

High-throughput

0.667

High

201629

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

3

8

High-throughput

0.667

High

541427

SYDC
Aspartate--tRNA ligase, cytoplasmic

3

12

High-throughput

0.667

High

1042723

CUL3
Cullin-3

3

4

High-throughput

0.667

High

58256

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

11

High-throughput

0.628

High

814550

SYQ
Glutamine--tRNA ligase

2

6

High-throughput

0.628

High

1019454

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

2

8

High-throughput

0.628

High

1065588

SYK
Lysine--tRNA ligase

2

12

High-throughput

0.628

High

1197879

SDCG8
Serologically defined colon cancer antigen 8

2

4

High-throughput

0.628

High

643924

SYVC
Valine--tRNA ligase

1

6

High-throughput

0.618

High

370611

ESR1
Estrogen receptor

2

4

Small-scale

0.585

High

228947

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

323242

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

4

High-throughput

0.584

High

581880

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

1024842

DUS4
Dual specificity protein phosphatase 4

2

3

High-throughput

0.571

High

644190

EF1G
Elongation factor 1-gamma

1

3

Small-scale

0.561

High

1230055

RPTOR
Regulatory-associated protein of mTOR

1

5

Small-scale

0.558

High

1343497

RRAGD
Ras-related GTP-binding protein D

1

2

Small-scale

0.554

High

507519

ERG
Transcriptional regulator ERG

1

2

High-throughput

0.541

High

283053

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

5

High-throughput

0.536

High

908193

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

1054007

CAPR1
Caprin-1

1

2

High-throughput

0.536

High

1062407

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

1082039

PKN2
Serine/threonine-protein kinase N2

1

6

High-throughput

0.536

High

1263570

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.536

High

1310987

ATGA1
Autophagy-related protein 101

1

1

High-throughput

0.536

High

787591

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.530

High

443858

VIME
Vimentin

1

2

High-throughput

0.515

High

807571

RS10
Small ribosomal subunit protein eS10

1

1

High-throughput

0.515

High

128659

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

255206

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

336610

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

1287208

FAF2
FAS-associated factor 2

1

0

High-throughput

0.513

High

1328622

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1350388

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.513

High

894546

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.501

High

1350379

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

259481

NIPS2
Protein NipSnap homolog 2

1

1

High-throughput

0.489

High

270839

FOXH1
Forkhead box protein H1

1

18

High-throughput

0.489

High

452904

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

3

High-throughput

0.489

High

601395

VDAC1
Voltage-dependent anion-selective channel protein 1

1

1

High-throughput

0.489

High

993350

FOXM1
Forkhead box protein M1

1

15

High-throughput

0.489

High

1243428

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.489

High

1306875

FOXB1
Forkhead box protein B1

1

20

High-throughput

0.489

High

1318651

FOXQ1
Forkhead box protein Q1

1

19

High-throughput

0.489

High

118918

GTPB1
GTP-binding protein 1

1

14

High-throughput

0.479

High

125770

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

159625

ML12B
Myosin regulatory light chain 12B

1

1

High-throughput

0.479

High

260160

VPS4B
Vacuolar protein sorting-associated protein 4B

1

2

High-throughput

0.479

High

272746

OFD1
Centriole and centriolar satellite protein OFD1

1

4

High-throughput

0.479

High

295347

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

303516

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

329990

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.479

High

348117

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

385644

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

387649

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

391479

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

1

High-throughput

0.479

High

398124

ISG15
Ubiquitin-like protein ISG15

1

4

High-throughput

0.479

High

419068

TPM3
Tropomyosin alpha-3 chain

1

2

High-throughput

0.479

High

428475

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

432322

HS90A
Heat shock protein HSP 90-alpha

1

11

High-throughput

0.479

High

438581

HS90B
Heat shock protein HSP 90-beta

1

11

High-throughput

0.479

High

444804

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

1

High-throughput

0.479

High

451322

TPM1
Tropomyosin alpha-1 chain

1

2

High-throughput

0.479

High

488822

ARAF
Serine/threonine-protein kinase A-Raf

1

5

High-throughput

0.479

High

500175

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

504885

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

553941

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

570138

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

609586

FGFR3
Fibroblast growth factor receptor 3

1

15

High-throughput

0.479

High

616564

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

625625

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

653399

PYR1
Multifunctional protein CAD

1

2

High-throughput

0.479

High

674983

PUR8
Adenylosuccinate lyase

1

1

High-throughput

0.479

High

685071

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

719206

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

729372

VGFR3
Vascular endothelial growth factor receptor 3

1

8

High-throughput

0.479

High

738283

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

7

High-throughput

0.479

High

742576

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

749920

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

771076

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.479

High

776843

STAT3
Signal transducer and activator of transcription 3

1

1

High-throughput

0.479

High

780245

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

782962

GARS
Glycine--tRNA ligase

1

3

High-throughput

0.479

High

788934

RS27
Small ribosomal subunit protein eS27

1

2

High-throughput

0.479

High

813806

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

818552

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

828040

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

High-throughput

0.479

High

843078

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.479

High

850220

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

868354

ATX3
Ataxin-3

1

2

High-throughput

0.479

High

870917

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

907766

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.479

High

909262

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

916940

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

926036

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

927613

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

929704

RACK1
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.479

High

930033

ACTG
Actin, cytoplasmic 2

1

1

High-throughput

0.479

High

932422

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

932901

EF1A1
Elongation factor 1-alpha 1

1

6

High-throughput

0.479

High

961305

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

978920

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1025580

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

3

High-throughput

0.479

High

1036164

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1037420

TBB3
Tubulin beta-3 chain

1

1

High-throughput

0.479

High

1050286

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

1064223

TNIP1
TNFAIP3-interacting protein 1

1

10

High-throughput

0.479

High

1064794

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

1066811

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1108743

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.479

High

1116600

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

1121126

GLE1
mRNA export factor GLE1

1

2

High-throughput

0.479

High

1129143

CYTSB
Cytospin-B

1

1

High-throughput

0.479

High

1146916

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

1148835

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1163889

RICTR
Rapamycin-insensitive companion of mTOR

1

3

High-throughput

0.479

High

1172077

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1174316

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

1199704

ZN598
E3 ubiquitin-protein ligase ZNF598

1

3

High-throughput

0.479

High

1200715

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1252530

LNX1
E3 ubiquitin-protein ligase LNX

1

1

Small-scale

0.479

High

1255713

RBCC1
RB1-inducible coiled-coil protein 1

1

4

High-throughput

0.479

High

1267208

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1270487

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.479

High

1271776

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.479

High

1281442

FBXW7
F-box/WD repeat-containing protein 7

1

5

Small-scale

0.479

High

1287416

OPTN
Optineurin

1

8

High-throughput

0.479

High

1289359

SPDLY
Protein Spindly

1

3

High-throughput

0.479

High

1304949

NECD
Necdin

1

1

High-throughput

0.479

High

1307029

ANM1
Protein arginine N-methyltransferase 1

1

5

High-throughput

0.479

High

1310535

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

1315521

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

1326190

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

3

High-throughput

0.479

High

1327002

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

4

High-throughput

0.479

High

1328278

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

1331508

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

1343733

ANLN
Anillin

1

2

High-throughput

0.479

High

1345444

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1346641

ATD3A
ATPase family AAA domain-containing protein 3A

1

3

High-throughput

0.479

High

1347296

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

1350376

DUX4
Double homeobox protein 4

1

4

High-throughput

0.479

High

1350377

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1350378

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

4

High-throughput

0.479

High

1350382

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.479

High

1350384

HDAC5
Histone deacetylase 5

1

4

High-throughput

0.479

High

1350385

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

1350389

NEMO
NF-kappa-B essential modulator

1

7

High-throughput

0.479

High

401159

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.458

High

575206

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

671354

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

685789

PRDX2
Peroxiredoxin-2

1

0

High-throughput

0.458

High

717392

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

750911

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.458

High

829074

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

842148

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

Small-scale

0.458

High

920839

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

963443

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

0

High-throughput

0.458

High

1017834

STX4
Syntaxin-4

1

0

High-throughput

0.458

High

1023249

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.458

High

1204355

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

1220408

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.458

High

1347487

OXSM
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

1

0

High-throughput

0.458

High

902782

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.457

High

568232

TAL1
T-cell acute lymphocytic leukemia protein 1

1

1

High-throughput

0.457

High

727816

SOX5
Transcription factor SOX-5

1

1

High-throughput

0.457

High

794571

ETV4
ETS translocation variant 4

1

2

High-throughput

0.457

High

375016

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.445

High

402567

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

529837

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

718267

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

983258

UBE3A
Ubiquitin-protein ligase E3A

1

2

High-throughput

0.445

High

1295607

NEUL4
Neuralized-like protein 4

1

1

High-throughput

0.445

High

1350386

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.445

High

1344788

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

169650

BET1
BET1 homolog

1

2

High-throughput

0.437

High

178024

TMPS2
Transmembrane protease serine 2

1

3

High-throughput

0.437

High

182936

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.437

High

328984

TOP3B
DNA topoisomerase 3-beta-1

1

2

High-throughput

0.437

High

363332

FINC
Fibronectin

1

3

High-throughput

0.437

High

391945

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.437

High

530762

ITA4
Integrin alpha-4

1

2

High-throughput

0.437

High

652481

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

721661

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

824482

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

918067

H4
Histone H4

1

2

High-throughput

0.437

High

1029964

TIF1B
Transcription intermediary factor 1-beta

1

4

High-throughput

0.437

High

1159313

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.437

High

1166026

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1188974

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1198210

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.437

High

1201733

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.437

High

1252229

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

1286119

LENG1
Leukocyte receptor cluster member 1

1

1

High-throughput

0.437

High

1316790

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

1333727

AKTIP
AKT-interacting protein

1

2

Small-scale

0.437

High

1334038

WDR76
WD repeat-containing protein 76

1

14

High-throughput

0.437

High

1336043

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.437

High

1350380

HECD1
E3 ubiquitin-protein ligase HECTD1

1

4

High-throughput

0.437

High

1350383

TRI33
E3 ubiquitin-protein ligase TRIM33

1

4

High-throughput

0.437

High

1350387

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

1150

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

1269816

ESR2
Estrogen receptor beta

1

4

High-throughput

0.407

High

1318877

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.407

High

831752

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.373

High

880523

ATP5I
ATP synthase subunit e, mitochondrial

2

0

High-throughput

0.313

High

234591

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

1288427

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

1314409

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

592045

RAB4A
Ras-related protein Rab-4A

1

0

High-throughput

0.249

Low

736085

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.249

Low

1183909

KCTD9
BTB/POZ domain-containing protein KCTD9

1

0

High-throughput

0.249

Low

1233986

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

1237021

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1348573

TMOD3
Tropomodulin-3

1

0

High-throughput

0.249

Low

1350381

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low

321231

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

397672

IPSP
Plasma serine protease inhibitor

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024