HitPredict

Interactor 1: AP2A1 (O95782)
AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)
Gene: AP2A1

Interactor 2: EPN1 (Q9Y6I3)
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)
Gene: EPN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10764745
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 977 Hs			1 576
+	Hs
		321545 AP2A1_HUMAN (1-977): 0: 904: 100.00		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Rn
		88757 D3ZUY8_RAT (1-977): 0: 872: 95.30		EPN1_RAT (1-576): 2.54e-91: 293: 94.27
+	Rn
		291395 Q66HM2_RAT (1-977): 0: 845: 79.39		EPN1_RAT (1-576): 2.54e-91: 293: 94.27
+	Rn
		291387 AP2A2_RAT (1-977): 0: 841: 79.18		EPN1_RAT (1-576): 2.54e-91: 293: 94.27
+	Hs
		302148 AP2A2_HUMAN (1-977): 0: 832: 76.97		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		302230 AP2A2_HUMAN (1-977): 0: 832: 76.97		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Hs
		203194 AP2A1_HUMAN (1-977): 0: 904: 100.00		SYNJ1_HUMAN (246-573): 8.14e-20: 96.3: 14.11
+	Dm
		954828 AP2A_DROME (3-977): 0: 784: 66.09		Q7KU90_DROME (1-571): 4.4e-58: 209: 31.51
+	Rn
		291389 AP2B1_RAT (34-972): 0: 676: 17.11		EPN1_RAT (1-576): 2.54e-91: 293: 94.27
+	At
		1228257 AP2A1_ARATH (8-977): 0: 727: 36.46		EPN1_ARATH (2-453): 4.14e-71: 240: 21.26
+	Hs
		925867 AP2B1_HUMAN (34-972): 0: 676: 17.11		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		926065 AP2B1_HUMAN (34-972): 0: 676: 17.11		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Hs
		1014011 AP1B1_HUMAN (34-972): 0: 668: 18.15		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Rn
		1144064 Q66HM2_RAT (1-977): 0: 845: 79.39		SYNJ1_RAT (246-575): 3.51e-15: 81.2: 14.67
+	Rn
		923862 AP2B1_RAT (34-972): 0: 676: 17.11		EPN2_RAT (1-562): 1.86e-67: 231: 42.44
+	At
		1147101 AP2A1_ARATH (8-977): 0: 727: 36.46		EPN2_ARATH (2-574): 1.39e-39: 156: 21.89
+	Sc
		743416 AP2A_YEAST (10-975): 0: 669: 24.70		ENT1_YEAST (3-228): 6.81e-62: 212: 36.73
+	Hs
		307524 AP2B1_HUMAN (34-972): 0: 676: 17.11		EPN2_HUMAN (1-566): 6.51e-54: 195: 38.02
+	Hs
		203219 AP2B1_HUMAN (34-972): 0: 676: 17.11		SYNJ1_HUMAN (246-573): 8.14e-20: 96.3: 14.11
+	Hs
		203223 AP1B1_HUMAN (34-972): 0: 668: 18.15		SYNJ1_HUMAN (246-573): 8.14e-20: 96.3: 14.11