Protein: PRP6
Pre-mRNA-splicing factor 6

Gene: PRP6
Organism: Saccharomyces cerevisiae S288C
Interactions: 145
UniProt ID: P19735

Gene Ontology (top 5):
GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0005634 - nucleus
GO:0005681 - spliceosomal complex
GO:0005682 - U5 snRNP

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

625029

PRP31
Pre-mRNA-processing factor 31

5

9

High-throughput

0.927

High

624993

PRP8
Pre-mRNA-splicing factor 8

4

10

Small-scale

0.892

High

625051

DIB1
Spliceosomal protein DIB1

3

3

High-throughput

0.843

High

624991

BRR2
Pre-mRNA-splicing helicase BRR2

9

20

Small-scale

0.751

High

624963

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

6

18

Small-scale

0.732

High

625042

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

5

2

High-throughput

0.718

High

625014

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

9

High-throughput

0.691

High

625026

LSM8
LSM2-LSM8 complex subunit LSM8

4

20

Small-scale

0.687

High

625061

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

4

3

Small-scale

0.684

High

625037

RUXF
Small nuclear ribonucleoprotein F

4

9

High-throughput

0.683

High

625038

LSM3
LSM complex subunit LSM3

4

20

Small-scale

0.678

High

624997

SN114
Pre-mRNA-splicing factor SNU114

3

13

High-throughput

0.662

High

625035

LSM7
LSM complex subunit LSM7

3

20

High-throughput

0.662

High

625041

SMD1
Small nuclear ribonucleoprotein Sm D1

3

3

High-throughput

0.662

High

625022

SMD3
Small nuclear ribonucleoprotein Sm D3

3

15

Small-scale

0.650

High

625018

RUXG
Small nuclear ribonucleoprotein G

3

20

High-throughput

0.643

High

625059

RUXE
Small nuclear ribonucleoprotein E

3

5

High-throughput

0.643

High

625005

SP381
Pre-mRNA-splicing factor SPP381

3

0

High-throughput

0.634

High

584338

GCN2
eIF-2-alpha kinase GCN2

2

4

High-throughput

0.621

High

625016

LSM5
LSM complex subunit LSM5

2

2

High-throughput

0.621

High

625002

LSM2
LSM complex subunit LSM2

2

15

High-throughput

0.611

High

625015

LSM4
LSM complex subunit LSM4

2

7

High-throughput

0.611

High

543770

SSB1
Ribosome-associated molecular chaperone SSB1

2

13

High-throughput

0.584

High

624980

HS104
Heat shock protein 104

2

6

High-throughput

0.584

High

625054

NCBP2
Nuclear cap-binding protein subunit 2

2

15

High-throughput

0.584

High

361417

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

403347

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

10

High-throughput

0.536

High

416193

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.536

High

569541

GCY1
Glycerol 2-dehydrogenase

1

1

High-throughput

0.536

High

624966

UBA1
Ubiquitin-activating enzyme E1 1

1

3

High-throughput

0.536

High

624983

APE2
Aminopeptidase 2, mitochondrial

1

1

High-throughput

0.536

High

625008

SSZ1
Ribosome-associated complex subunit SSZ1

1

6

High-throughput

0.536

High

625049

LSM6
LSM complex subunit LSM6

1

9

High-throughput

0.536

High

625053

KAR
NADPH-dependent alpha-keto amide reductase

1

2

High-throughput

0.536

High

452559

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.513

High

566481

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.513

High

591941

THRC
Threonine synthase

1

0

High-throughput

0.513

High

624977

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.513

High

624979

CYS3
Cystathionine gamma-lyase

1

0

High-throughput

0.513

High

625004

HSL7
Protein arginine N-methyltransferase HSL7

1

0

High-throughput

0.513

High

625020

ERG10
Acetyl-CoA acetyltransferase

1

0

High-throughput

0.513

High

625028

ADK
Adenosine kinase

1

0

High-throughput

0.513

High

625033

ACS2
Acetyl-coenzyme A synthetase 2

1

0

High-throughput

0.513

High

625032

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.508

High

599319

FUS3
Mitogen-activated protein kinase FUS3

1

2

High-throughput

0.501

High

624967

KC11
Casein kinase I homolog 1

1

5

High-throughput

0.501

High

624968

KC12
Casein kinase I homolog 2

1

5

High-throughput

0.501

High

625027

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

4

High-throughput

0.501

High

358963

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

3

High-throughput

0.500

High

392202

HSP82
ATP-dependent molecular chaperone HSP82

1

6

High-throughput

0.500

High

416516

HXKB
Hexokinase-2

1

3

High-throughput

0.500

High

454075

DHE4
NADP-specific glutamate dehydrogenase 1

1

1

High-throughput

0.500

High

481475

HSP73
Heat shock protein SSA3

1

12

High-throughput

0.500

High

597030

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.500

High

624972

CDC48
Cell division control protein 48

1

3

High-throughput

0.500

High

624988

HSP79
Heat shock protein homolog SSE2

1

17

High-throughput

0.500

High

624995

BMH2
Protein BMH2

1

5

High-throughput

0.500

High

624996

EF1G2
Elongation factor 1-gamma 2

1

3

High-throughput

0.500

High

625047

NGK1
N-acetylglucosamine kinase

1

3

High-throughput

0.494

High

438615

SC160
Protein SCP160

1

14

High-throughput

0.489

High

470630

ERG20
Farnesyl pyrophosphate synthase

1

1

High-throughput

0.489

High

481852

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.489

High

581820

SYKC
Lysine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.489

High

598946

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.489

High

604896

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

624971

CDC10
Cell division control protein 10

1

2

High-throughput

0.489

High

624976

TRXB1
Thioredoxin reductase 1

1

1

High-throughput

0.489

High

624982

MDHP
Malate dehydrogenase, peroxisomal

1

2

High-throughput

0.489

High

624989

FIMB
Fimbrin

1

2

High-throughput

0.489

High

624998

PGM2
Phosphoglucomutase 2

1

1

High-throughput

0.489

High

624999

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

1

High-throughput

0.489

High

625000

SYG
Glycine--tRNA ligase 1, mitochondrial

1

1

High-throughput

0.489

High

625001

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

1

High-throughput

0.489

High

625003

OLA1
Obg-like ATPase 1

1

3

High-throughput

0.489

High

625006

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.489

High

625019

SYA
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.489

High

625031

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

4

High-throughput

0.489

High

625040

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

2

High-throughput

0.489

High

625044

CLU
Clustered mitochondria protein 1

1

3

High-throughput

0.489

High

366766

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.479

High

408285

GAL1
Galactokinase

1

0

High-throughput

0.479

High

439235

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

624978

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.479

High

624974

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

624975

BMH1
Protein BMH1

1

5

High-throughput

0.479

High

624985

PRP21
Pre-mRNA-splicing factor PRP21

1

6

High-throughput

0.479

High

625012

IFH1
Protein IFH1

1

2

High-throughput

0.479

High

625021

PFS2
Polyadenylation factor subunit 2

1

20

High-throughput

0.479

High

625030

SF3B1
U2 snRNP component HSH155

1

10

High-throughput

0.479

High

625043

CWC21
Pre-mRNA-splicing factor CWC21

1

2

Small-scale

0.479

High

625045

PDS5
Sister chromatid cohesion protein PDS5

1

4

High-throughput

0.479

High

625046

RSE1
Pre-mRNA-splicing factor RSE1

1

3

High-throughput

0.479

High

625048

SMD2
Small nuclear ribonucleoprotein Sm D2

1

5

High-throughput

0.479

High

625052

PRP11
Pre-mRNA-splicing factor PRP11

1

5

High-throughput

0.479

High

625055

RU2A
U2 small nuclear ribonucleoprotein A'

1

11

High-throughput

0.479

High

625056

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

625057

YRA1
RNA annealing protein YRA1

1

10

High-throughput

0.479

High

624964

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

1

19

High-throughput

0.470

High

624990

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

625039

PRP38
Pre-mRNA-splicing factor 38

1

0

High-throughput

0.458

High

625060

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

625050

SP382
Pre-mRNA-splicing factor SPP382

1

3

High-throughput

0.457

High

359426

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

3

High-throughput

0.457

High

367688

ENO1
Enolase 1

1

2

High-throughput

0.457

High

405022

LEU3
3-isopropylmalate dehydrogenase

1

2

High-throughput

0.457

High

416366

HXKA
Hexokinase-1

1

3

High-throughput

0.457

High

460308

SYV
Valine--tRNA ligase, mitochondrial

1

1

High-throughput

0.457

High

518196

IF4A
ATP-dependent RNA helicase eIF4A

1

7

High-throughput

0.457

High

578818

HSC82
ATP-dependent molecular chaperone HSC82

1

6

High-throughput

0.457

High

591997

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.457

High

598804

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

1

High-throughput

0.457

High

607729

HXKG
Glucokinase-1

1

3

High-throughput

0.457

High

610087

PDI
Protein disulfide-isomerase

1

3

High-throughput

0.457

High

624962

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.457

High

624973

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

1

High-throughput

0.457

High

624981

EF2
Elongation factor 2

1

13

High-throughput

0.457

High

624986

CBS
Cystathionine beta-synthase

1

1

High-throughput

0.457

High

625007

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

1

High-throughput

0.457

High

625013

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.457

High

625023

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

4

High-throughput

0.457

High

625024

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.457

High

625034

ARO8
Aromatic/aminoadipate aminotransferase 1

1

1

High-throughput

0.457

High

625036

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

4

High-throughput

0.457

High

523012

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.445

High

624970

SIS1
Protein SIS1

1

7

High-throughput

0.445

High

624984

PRP19
Pre-mRNA-processing factor 19

1

18

Small-scale

0.445

High

624987

HSP7F
Heat shock protein homolog SSE1

1

17

High-throughput

0.445

High

625017

SSB2
Ribosome-associated molecular chaperone SSB2

1

13

High-throughput

0.445

High

624994

HSP78
Heat shock protein 78, mitochondrial

1

7

High-throughput

0.407

High

625011

TCPB
T-complex protein 1 subunit beta

1

7

High-throughput

0.407

High

625025

PFD1
Prefoldin subunit 1

1

2

High-throughput

0.407

High

446205

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.279

Low

624969

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.279

Low

625009

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.279

Low

625010

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.279

Low

625058

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

High-throughput

0.279

Low

367357

CISY1
Citrate synthase, mitochondrial

1

0

High-throughput

0.261

Low

408552

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

432286

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.261

Low

439085

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.261

Low

555002

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

572512

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.261

Low

622314

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.261

Low

624965

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

624992

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025