HitPredict

Interactor 1: RIGI (O95786)
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
Gene: RIGI

Interactor 2: STING (Q86WV6)
Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)
Gene: STING1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.657

The method score is based on:

Property	Details
Experiments	22312431, 18724357, 18818105
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002230 - positive regulation of defense response to virus by host GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0032728 - positive regulation of interferon-beta production and 5 others more... GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051607 - defense response to virus GO:0071360 - cellular response to exogenous dsRNA GO:0140374 - antiviral innate immune response
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	925
Hs

1	379

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024