Protein: NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)

Gene: NHRF2, NHERF2
Organism: Homo sapiens
Interactions: 152
UniProt ID: Q15599

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005634 - nucleus
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0008013 - beta-catenin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

547069

EZRI
Ezrin

4

20

Small-scale

0.900

High

350190

RASK
GTPase KRas

2

20

High-throughput

0.754

High

914086

RB11A
Ras-related protein Rab-11A

2

6

High-throughput

0.754

High

529166

CFTR
Cystic fibrosis transmembrane conductance regulator

8

18

Small-scale

0.753

High

1075407

ITSN1
Intersectin-1

2

20

High-throughput

0.737

High

808637

YAP1
Transcriptional coactivator YAP1

6

20

Small-scale

0.735

High

1066026

ARHG6
Rho guanine nucleotide exchange factor 6

2

8

High-throughput

0.726

High

134469

PODXL
Podocalyxin

5

9

Small-scale

0.726

High

1075405

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

18

Small-scale

0.713

High

1075439

OTUL
Ubiquitin thioesterase otulin

2

5

Small-scale

0.705

High

791

A0A087WZU1
protein-tyrosine-phosphatase

1

20

High-throughput

0.691

High

153922

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

17

High-throughput

0.691

High

719720

RADI
Radixin

1

17

High-throughput

0.691

High

1049707

ARHG7
Rho guanine nucleotide exchange factor 7

1

8

High-throughput

0.691

High

1075475

BAIP2
BAR/IMD domain-containing adapter protein 2

1

13

High-throughput

0.691

High

1075481

USH1C
Harmonin

1

19

High-throughput

0.691

High

232891

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

3

16

High-throughput

0.671

High

1075464

LPAR2
Lysophosphatidic acid receptor 2

3

20

Small-scale

0.667

High

119395

LEG9
Galectin-9

3

3

High-throughput

0.667

High

968255

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

2

5

Small-scale

0.644

High

117007

SGK1
Serine/threonine-protein kinase Sgk1

2

20

Small-scale

0.639

High

211585

ACTN4
Alpha-actinin-4

2

16

Small-scale

0.639

High

1068463

KPCD1
Serine/threonine-protein kinase D1

2

18

High-throughput

0.628

High

1075465

KCTD5
BTB/POZ domain-containing protein KCTD5

2

20

High-throughput

0.628

High

983043

SRY
Sex-determining region Y protein

2

1

Small-scale

0.626

High

1075456

WWTR1
WW domain-containing transcription regulator protein 1

2

20

Small-scale

0.621

High

1075416

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

18

Small-scale

0.621

High

179358

MRP4
ATP-binding cassette sub-family C member 4

2

9

Small-scale

0.619

High

1075449

TB10A
TBC1 domain family member 10A

2

8

Small-scale

0.619

High

884496

RAB25
Ras-related protein Rab-25

1

7

High-throughput

0.618

High

915696

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1075423

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

3

17

High-throughput

0.613

High

617559

CRCM
Colorectal mutant cancer protein

2

6

Small-scale

0.611

High

125481

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

10

High-throughput

0.606

High

1075448

TRAF4
TNF receptor-associated factor 4

2

12

High-throughput

0.606

High

1075476

DLGP4
Disks large-associated protein 4

2

20

High-throughput

0.606

High

890679

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

12

Small-scale

0.596

High

429050

ADRB2
Beta-2 adrenergic receptor

2

20

Small-scale

0.595

High

427569

ANXA2
Annexin A2

1

2

Small-scale

0.586

High

1075409

RHG44
Rho GTPase-activating protein 44

2

15

High-throughput

0.574

High

369674

ESR1
Estrogen receptor

2

17

High-throughput

0.571

High

1075420

RHGBA
Rho GTPase-activating protein 11A

2

19

High-throughput

0.571

High

777385

S26A3
Chloride anion exchanger

1

6

Small-scale

0.561

High

976333

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

20

Small-scale

0.561

High

1053568

GRM2
Metabotropic glutamate receptor 2

1

12

Small-scale

0.561

High

1059610

GRM3
Metabotropic glutamate receptor 3

1

9

Small-scale

0.561

High

1075422

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.553

High

452428

PGFRB
Platelet-derived growth factor receptor beta

1

17

Small-scale

0.536

High

330564

ZBED1
E3 SUMO-protein ligase ZBED1

1

4

High-throughput

0.536

High

449267

LEG1
Galectin-1

1

3

High-throughput

0.536

High

521550

ACTN1
Alpha-actinin-1

1

16

High-throughput

0.536

High

639589

TNR5
Tumor necrosis factor receptor superfamily member 5

1

4

High-throughput

0.536

High

685968

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

716688

CTNA1
Catenin alpha-1

1

8

High-throughput

0.536

High

717109

CTNB1
Catenin beta-1

1

14

High-throughput

0.536

High

792780

EAA3
Excitatory amino acid transporter 3

1

9

High-throughput

0.536

High

864829

MK12
Mitogen-activated protein kinase 12

1

12

High-throughput

0.536

High

897251

CSN2
COP9 signalosome complex subunit 2

1

3

High-throughput

0.536

High

980100

ATP7A
Copper-transporting ATPase 1

1

1

High-throughput

0.536

High

1021113

FOXC1
Forkhead box protein C1

1

6

High-throughput

0.536

High

1026169

PAK1
Serine/threonine-protein kinase PAK 1

1

11

High-throughput

0.536

High

1026913

PAK2
Serine/threonine-protein kinase PAK 2

1

11

High-throughput

0.536

High

1050110

GIT2
ARF GTPase-activating protein GIT2

1

20

High-throughput

0.536

High

1075410

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

2

High-throughput

0.536

High

1075412

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

2

High-throughput

0.536

High

1075414

COL12
Collectin-12

1

2

High-throughput

0.536

High

1075417

RHG17
Rho GTPase-activating protein 17

1

17

High-throughput

0.536

High

1075424

CSN6
COP9 signalosome complex subunit 6

1

2

High-throughput

0.536

High

1075431

STEA2
Metalloreductase STEAP2

1

1

High-throughput

0.536

High

1075436

KIFA3
Kinesin-associated protein 3

1

15

High-throughput

0.536

High

1075437

CSN5
COP9 signalosome complex subunit 5

1

9

High-throughput

0.536

High

1075438

LPP
Lipoma-preferred partner

1

9

High-throughput

0.536

High

1075440

TMA16
Translation machinery-associated protein 16

1

1

High-throughput

0.536

High

1075441

MRAP2
Melanocortin-2 receptor accessory protein 2

1

1

High-throughput

0.536

High

1075443

O52B2
Olfactory receptor 52B2

1

8

High-throughput

0.536

High

1075444

CSN8
COP9 signalosome complex subunit 8

1

1

High-throughput

0.536

High

1075453

KPCD2
Serine/threonine-protein kinase D2

1

18

High-throughput

0.536

High

1075458

CAD23
Cadherin-23

1

7

High-throughput

0.536

High

1075462

CSN7B
COP9 signalosome complex subunit 7b

1

2

High-throughput

0.536

High

1075463

CYBP
Calcyclin-binding protein

1

2

High-throughput

0.536

High

1075466

PDXL2
Podocalyxin-like protein 2

1

8

High-throughput

0.536

High

1075468

DTL
Denticleless protein homolog

1

2

High-throughput

0.536

High

1075469

CSN7A
COP9 signalosome complex subunit 7a

1

2

High-throughput

0.536

High

1075473

CSN3
COP9 signalosome complex subunit 3

1

3

High-throughput

0.536

High

1075474

WASF3
Actin-binding protein WASF3

1

7

High-throughput

0.536

High

1075477

GIT1
ARF GTPase-activating protein GIT1

1

20

High-throughput

0.536

High

1075479

KCTD3
BTB/POZ domain-containing protein KCTD3

1

20

High-throughput

0.536

High

1075480

S4A7
Sodium bicarbonate cotransporter 3

1

11

High-throughput

0.536

High

1075451

ACE2
Angiotensin-converting enzyme 2

1

4

Small-scale

0.527

High

816143

KCNJ1
ATP-sensitive inward rectifier potassium channel 1

1

20

Small-scale

0.527

High

950190

SMAD3
Mothers against decapentaplegic homolog 3

1

3

Small-scale

0.515

High

1075418

OTU7B
OTU domain-containing protein 7B

1

10

High-throughput

0.515

High

920777

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.513

High

1035077

TUSC3
Tumor suppressor candidate 3

1

0

High-throughput

0.513

High

1058083

PSF1
DNA replication complex GINS protein PSF1

1

0

High-throughput

0.513

High

1075446

CSN4
COP9 signalosome complex subunit 4

1

0

High-throughput

0.513

High

1075467

SMAL1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

1

0

High-throughput

0.513

High

1075471

NUDT5
ADP-sugar pyrophosphatase

1

0

High-throughput

0.513

High

1075426

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

5

Small-scale

0.506

High

475804

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.501

High

566396

KPCA
Protein kinase C alpha type

1

19

Small-scale

0.501

High

822757

SL9A3
Sodium/hydrogen exchanger 3

1

5

Small-scale

0.501

High

1075450

S26A6
Solute carrier family 26 member 6

1

6

Small-scale

0.501

High

300481

FRYL
Protein furry homolog-like

1

2

High-throughput

0.489

High

850657

KS6A3
Ribosomal protein S6 kinase alpha-3

1

20

High-throughput

0.489

High

1057222

KCTD2
BTB/POZ domain-containing protein KCTD2

1

20

High-throughput

0.489

High

1075415

TCHL1
Trichohyalin-like protein 1

1

4

High-throughput

0.489

High

1075421

KLH24
Kelch-like protein 24

1

9

High-throughput

0.489

High

1075428

PTGR3
Prostaglandin reductase 3

1

1

High-throughput

0.489

High

1075429

KCD17
BTB/POZ domain-containing protein KCTD17

1

20

High-throughput

0.489

High

1075432

SHKB1
SH3KBP1-binding protein 1

1

20

High-throughput

0.489

High

1075434

PSMF1
Proteasome inhibitor PI31 subunit

1

1

High-throughput

0.489

High

1075435

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.489

High

1075442

RIPR3
RIPOR family member 3

1

2

High-throughput

0.489

High

1075445

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

1

1

High-throughput

0.489

High

1075452

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

1

High-throughput

0.489

High

1075457

BTBD1
BTB/POZ domain-containing protein 1

1

10

High-throughput

0.489

High

1075459

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

20

High-throughput

0.489

High

1075461

RNF41
E3 ubiquitin-protein ligase NRDP1

1

13

High-throughput

0.489

High

1075454

S13A1
Solute carrier family 13 member 1

1

2

Small-scale

0.481

High

166374

KIF3B
Kinesin-like protein KIF3B

1

20

High-throughput

0.479

High

182164

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

9

Small-scale

0.479

High

430191

PROF1
Profilin-1

1

1

Small-scale

0.479

High

521951

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

664359

AA2BR
Adenosine receptor A2b

1

20

Small-scale

0.479

High

793323

MUC18
Cell surface glycoprotein MUC18

1

17

High-throughput

0.479

High

1075406

TRIP6
Thyroid receptor-interacting protein 6

1

11

Small-scale

0.479

High

1075411

MIDN
Midnolin

1

3

High-throughput

0.479

High

1075413

PKHG4
Puratrophin-1

1

12

High-throughput

0.479

High

1075433

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.479

High

1075460

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1075470

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1075472

BRPF3
Bromodomain and PHD finger-containing protein 3

1

5

High-throughput

0.479

High

1075478

KIF3A
Kinesin-like protein KIF3A

1

20

High-throughput

0.479

High

1075455

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.458

High

966810

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

12

Small-scale

0.457

High

240010

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.445

High

1075419

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

100790

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

856141

CHIO
Beta-chimaerin

1

7

High-throughput

0.437

High

961593

PLCB2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

1

5

Small-scale

0.437

High

1075408

E2F4
Transcription factor E2F4

1

2

High-throughput

0.437

High

1075427

AHI1
Jouberin

1

7

High-throughput

0.437

High

149

A0A024R6X4
PLEKHG4

1

12

High-throughput

0.407

High

1073423

KS6A1
Ribosomal protein S6 kinase alpha-1

1

20

Small-scale

0.373

High

664088

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.279

Low

986424

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

0

High-throughput

0.279

Low

1067270

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

1

0

High-throughput

0.279

Low

1075425

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

High-throughput

0.279

Low

1075430

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1075447

G6PC3
Glucose-6-phosphatase 3

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024