Protein: NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)

Gene: NHRF2, NHERF2
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q15599

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005634 - nucleus
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0008013 - beta-catenin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

582808

EZRI
Ezrin

4

20

Small-scale

0.900

High

1121951

ARHG7
Rho guanine nucleotide exchange factor 7

2

8

High-throughput

0.776

High

1140173

ARHG6
Rho guanine nucleotide exchange factor 6

3

8

High-throughput

0.765

High

456741

ANXA2
Annexin A2

1

2

Small-scale

0.761

High

375546

RASK
GTPase KRas

2

20

High-throughput

0.754

High

976285

RB11A
Ras-related protein Rab-11A

2

6

High-throughput

0.754

High

563814

CFTR
Cystic fibrosis transmembrane conductance regulator

8

18

Small-scale

0.753

High

1150463

OTUL
Ubiquitin thioesterase otulin

3

5

Small-scale

0.751

High

862162

YAP1
Transcriptional coactivator YAP1

7

20

Small-scale

0.746

High

141928

PODXL
Podocalyxin

6

9

Small-scale

0.738

High

1150424

ITSN1
Intersectin-1

2

20

High-throughput

0.737

High

1150422

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

17

Small-scale

0.724

High

788

A0A087WZU1
Phosphatidylinositol phosphatase PTPRQ

1

20

High-throughput

0.691

High

162835

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

17

High-throughput

0.691

High

767441

RADI
Radixin

1

17

High-throughput

0.691

High

1150505

BAIP2
BAR/IMD domain-containing adapter protein 2

1

13

High-throughput

0.691

High

1150511

USH1C
Harmonin

1

19

High-throughput

0.691

High

247339

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

3

16

High-throughput

0.675

High

1150442

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

3

17

High-throughput

0.675

High

1034101

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

3

5

Small-scale

0.674

High

1150490

LPAR2
Lysophosphatidic acid receptor 2

3

20

Small-scale

0.667

High

125476

LEG9
Galectin-9

3

4

High-throughput

0.667

High

1143052

KPCD1
Serine/threonine-protein kinase D1

3

18

High-throughput

0.662

High

1150493

KCTD5
BTB/POZ domain-containing protein KCTD5

3

20

High-throughput

0.662

High

1150475

TB10A
TBC1 domain family member 10A

3

9

Small-scale

0.656

High

659485

CRCM
Colorectal mutant cancer protein

3

6

Small-scale

0.650

High

122954

SGK1
Serine/threonine-protein kinase Sgk1

2

20

Small-scale

0.639

High

224714

ACTN4
Alpha-actinin-4

2

16

Small-scale

0.639

High

1150426

RHG44
Rho GTPase-activating protein 44

2

14

High-throughput

0.628

High

1050337

SRY
Sex-determining region Y protein

2

1

Small-scale

0.626

High

1150482

WWTR1
WW domain-containing transcription regulator protein 1

2

20

Small-scale

0.621

High

1150434

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

17

Small-scale

0.621

High

190609

MRP4
ATP-binding cassette sub-family C member 4

2

9

Small-scale

0.619

High

945001

RAB25
Ras-related protein Rab-25

1

7

High-throughput

0.618

High

978026

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

132062

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

13

High-throughput

0.606

High

1150474

TRAF4
TNF receptor-associated factor 4

2

10

High-throughput

0.606

High

1150506

DLGP4
Disks large-associated protein 4

2

20

High-throughput

0.606

High

354225

ZBED1
E3 SUMO-protein ligase ZBED1

2

4

High-throughput

0.601

High

480798

LEG1
Galectin-1

2

4

High-throughput

0.601

High

1047218

ATP7A
Copper-transporting ATPase 1

2

1

High-throughput

0.601

High

1096440

PAK1
Serine/threonine-protein kinase PAK 1

2

13

High-throughput

0.601

High

1122394

GIT2
ARF GTPase-activating protein GIT2

2

20

High-throughput

0.601

High

1150436

RHG17
Rho GTPase-activating protein 17

2

18

High-throughput

0.601

High

1150479

KPCD2
Serine/threonine-protein kinase D2

2

18

High-throughput

0.601

High

1150489

CYBP
Calcyclin-binding protein

2

2

High-throughput

0.601

High

1150507

GIT1
ARF GTPase-activating protein GIT1

2

20

High-throughput

0.601

High

1150509

KCTD3
BTB/POZ domain-containing protein KCTD3

2

20

High-throughput

0.601

High

951689

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

12

Small-scale

0.596

High

458410

ADRB2
Beta-2 adrenergic receptor

2

20

Small-scale

0.595

High

396181

ESR1
Estrogen receptor

2

17

High-throughput

0.571

High

1150439

RHGBA
Rho GTPase-activating protein 11A

2

19

High-throughput

0.571

High

828574

S26A3
Chloride anion exchanger

1

6

Small-scale

0.561

High

1042744

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

20

Small-scale

0.561

High

1126088

GRM2
Metabotropic glutamate receptor 2

1

12

Small-scale

0.561

High

1132686

GRM3
Metabotropic glutamate receptor 3

1

9

Small-scale

0.561

High

1150441

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.553

High

321912

FRYL
Protein furry homolog-like

2

3

High-throughput

0.549

High

1130005

KCTD2
BTB/POZ domain-containing protein KCTD2

2

20

High-throughput

0.549

High

1150450

PTGR3
Prostaglandin reductase 3

2

1

High-throughput

0.549

High

1150451

KCD17
BTB/POZ domain-containing protein KCTD17

2

20

High-throughput

0.549

High

1150456

SHKB1
SH3KBP1-binding protein 1

2

20

High-throughput

0.549

High

1150487

RNF41
E3 ubiquitin-protein ligase NRDP1

2

14

High-throughput

0.549

High

484146

PGFRB
Platelet-derived growth factor receptor beta

1

18

Small-scale

0.536

High

555692

ACTN1
Alpha-actinin-1

1

16

High-throughput

0.536

High

683246

TNR5
Tumor necrosis factor receptor superfamily member 5

1

5

High-throughput

0.536

High

732606

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

764341

CTNA1
Catenin alpha-1

1

8

High-throughput

0.536

High

764778

CTNB1
Catenin beta-1

1

14

High-throughput

0.536

High

845032

EAA3
Excitatory amino acid transporter 3

1

9

High-throughput

0.536

High

923350

MK12
Mitogen-activated protein kinase 12

1

12

High-throughput

0.536

High

958643

CSN2
COP9 signalosome complex subunit 2

1

3

High-throughput

0.536

High

1091106

FOXC1
Forkhead box protein C1

1

6

High-throughput

0.536

High

1097198

PAK2
Serine/threonine-protein kinase PAK 2

1

12

High-throughput

0.536

High

1150427

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

2

High-throughput

0.536

High

1150429

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

3

High-throughput

0.536

High

1150431

COL12
Collectin-12

1

2

High-throughput

0.536

High

1150437

OTU7B
OTU domain-containing protein 7B

1

10

High-throughput

0.536

High

1150443

CSN6
COP9 signalosome complex subunit 6

1

2

High-throughput

0.536

High

1150454

STEA2
Metalloreductase STEAP2

1

1

High-throughput

0.536

High

1150460

KIFA3
Kinesin-associated protein 3

1

15

High-throughput

0.536

High

1150461

CSN5
COP9 signalosome complex subunit 5

1

9

High-throughput

0.536

High

1150462

LPP
Lipoma-preferred partner

1

10

High-throughput

0.536

High

1150464

TMA16
Translation machinery-associated protein 16

1

1

High-throughput

0.536

High

1150465

MRAP2
Melanocortin-2 receptor accessory protein 2

1

1

High-throughput

0.536

High

1150469

O52B2
Olfactory receptor 52B2

1

2

High-throughput

0.536

High

1150470

CSN8
COP9 signalosome complex subunit 8

1

1

High-throughput

0.536

High

1150484

CAD23
Cadherin-23

1

7

High-throughput

0.536

High

1150485

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

20

High-throughput

0.536

High

1150488

CSN7B
COP9 signalosome complex subunit 7b

1

2

High-throughput

0.536

High

1150494

PDXL2
Podocalyxin-like protein 2

1

8

High-throughput

0.536

High

1150496

DTL
Denticleless protein homolog

1

2

High-throughput

0.536

High

1150498

CSN7A
COP9 signalosome complex subunit 7a

1

2

High-throughput

0.536

High

1150503

CSN3
COP9 signalosome complex subunit 3

1

3

High-throughput

0.536

High

1150504

WASF3
Actin-binding protein WASF3

1

7

High-throughput

0.536

High

1150510

S4A7
Sodium bicarbonate cotransporter 3

1

11

High-throughput

0.536

High

1150477

ACE2
Angiotensin-converting enzyme 2

1

4

Small-scale

0.527

High

870025

KCNJ1
ATP-sensitive inward rectifier potassium channel 1

1

20

Small-scale

0.527

High

1014521

SMAD3
Mothers against decapentaplegic homolog 3

1

3

Small-scale

0.515

High

983288

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.513

High

1106158

TUSC3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3

1

0

High-throughput

0.513

High

1130899

PSF1
DNA replication complex GINS protein PSF1

1

0

High-throughput

0.513

High

1150472

CSN4
COP9 signalosome complex subunit 4

1

0

High-throughput

0.513

High

1150495

SMAL1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

1

0

High-throughput

0.513

High

1150500

NUDT5
ADP-sugar pyrophosphatase

1

0

High-throughput

0.513

High

1150447

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

5

Small-scale

0.506

High

508020

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.501

High

603276

KPCA
Protein kinase C alpha type

1

19

Small-scale

0.501

High

783070

TCF7
Transcription factor 7

1

4

Small-scale

0.501

High

877669

SL9A3
Sodium/hydrogen exchanger 3

1

6

Small-scale

0.501

High

1150476

S26A6
Solute carrier family 26 member 6

1

6

Small-scale

0.501

High

908117

KS6A3
Ribosomal protein S6 kinase alpha-3

1

20

High-throughput

0.489

High

1150432

TCHL1
Trichohyalin-like protein 1

1

4

High-throughput

0.489

High

1150440

KLH24
Kelch-like protein 24

1

9

High-throughput

0.489

High

1150458

PSMF1
Proteasome inhibitor PI31 subunit

1

1

High-throughput

0.489

High

1150459

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.489

High

1150467

RIPR3
RIPOR family member 3

1

2

High-throughput

0.489

High

1150471

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

1

1

High-throughput

0.489

High

1150478

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

1

High-throughput

0.489

High

1150483

BTBD1
BTB/POZ domain-containing protein 1

1

10

High-throughput

0.489

High

1150480

S13A1
Solute carrier family 13 member 1

1

2

Small-scale

0.481

High

176611

KIF3B
Kinesin-like protein KIF3B

1

20

High-throughput

0.479

High

193580

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

5

Small-scale

0.479

High

459603

PROF1
Profilin-1

1

1

Small-scale

0.479

High

556101

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

709265

AA2BR
Adenosine receptor A2b

1

20

Small-scale

0.479

High

845651

MUC18
Cell surface glycoprotein MUC18

1

16

High-throughput

0.479

High

1150423

TRIP6
Thyroid receptor-interacting protein 6

1

12

Small-scale

0.479

High

1150428

MIDN
Midnolin

1

3

High-throughput

0.479

High

1150430

PKHG4
Puratrophin-1

1

12

High-throughput

0.479

High

1150445

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

13

High-throughput

0.479

High

1150457

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.479

High

1150486

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1150499

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1150501

BRPF3
Bromodomain and PHD finger-containing protein 3

1

4

High-throughput

0.479

High

1150508

KIF3A
Kinesin-like protein KIF3A

1

20

High-throughput

0.479

High

1150481

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

1032585

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

12

Small-scale

0.457

High

220597

AKA10
A-kinase anchor protein 10, mitochondrial

1

2

High-throughput

0.445

High

255038

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.445

High

297103

PAK3
Serine/threonine-protein kinase PAK 3

1

12

High-throughput

0.445

High

609683

LEG3
Galectin-3

1

4

High-throughput

0.445

High

668600

APC
Adenomatous polyposis coli protein

1

20

High-throughput

0.445

High

907014

CCR6
C-C chemokine receptor type 6

1

15

High-throughput

0.445

High

1150438

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

1150448

AMOL1
Angiomotin-like protein 1

1

20

High-throughput

0.445

High

1150491

HOME3
Homer protein homolog 3

1

12

High-throughput

0.445

High

1150497

S53A1
Solute carrier family 53 member 1

1

1

High-throughput

0.445

High

105987

APRIO
Alternative prion protein

1

7

High-throughput

0.437

High

914010

CHIO
Beta-chimaerin

1

8

High-throughput

0.437

High

1026937

PLCB2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

1

5

Small-scale

0.437

High

1150425

E2F4
Transcription factor E2F4

1

2

High-throughput

0.437

High

1150449

AHI1
Jouberin

1

7

High-throughput

0.437

High

960433

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.426

High

149

A0A024R6X4
PLEKHG4

1

12

High-throughput

0.407

High

1150433

MF14B
Hippocampus abundant transcript-like protein 1

1

4

High-throughput

0.407

High

1150435

FRY
Protein furry homolog

1

3

High-throughput

0.407

High

1150455

TRI58
E3 ubiquitin-protein ligase TRIM58

1

2

High-throughput

0.407

High

1150468

HS12B
Heat shock 70 kDa protein 12B

1

2

High-throughput

0.407

High

1150492

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

1

3

High-throughput

0.407

High

1150502

KDIS
Kinase D-interacting substrate of 220 kDa

1

12

High-throughput

0.407

High

1148334

KS6A1
Ribosomal protein S6 kinase alpha-1

1

20

Small-scale

0.373

High

1141447

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

2

0

High-throughput

0.313

High

1150444

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

2

0

High-throughput

0.313

High

708972

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.279

Low

1054180

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

0

High-throughput

0.279

Low

1150452

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1150473

G6PC3
Glucose-6-phosphatase 3

1

0

High-throughput

0.279

Low

1150446

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.232

Low

1150453

DDHD1
Phospholipase DDHD1

1

0

High-throughput

0.232

Low

1150466

CC120
Coiled-coil domain-containing protein 120

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025