HitPredict

Interactor 1: TTC4 (O95801)
Tetratricopeptide repeat protein 4 (TPR repeat protein 4)
Gene: TTC4

Interactor 2: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	19875381, 21360678, 25036637
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 387 Hs			1 732
+	Hs
		111932 TTC4_HUMAN (1-387): 1.31e-88: 274: 100.00		K9JA46_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		323394 TTC4_HUMAN (1-387): 1.31e-88: 274: 100.00		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		111940 UN45B_HUMAN (75-276): 2.24e-41: 157: 23.08		K9JA46_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		432038 UN45B_HUMAN (75-276): 2.24e-41: 157: 23.08		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Dm
		51550 TTC4_DROME (2-382): 3.22e-63: 209: 30.45		HSP83_DROME (15-732): 0: 1034: 78.41
+	Hs
		111937 FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56		K9JA46_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431818 FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		111935 PPP5_HUMAN (63-268): 4.43e-41: 153: 16.99		K9JA46_HUMAN (1-732): 0: 1087: 100.00
+	Hs
		431681 PPP5_HUMAN (63-268): 4.43e-41: 153: 16.99		HS90A_HUMAN (1-732): 0: 1087: 100.00
+	Mm
		432427 PPP5_MOUSE (63-268): 6.6e-41: 152: 16.51		HS90A_MOUSE (1-732): 0: 1083: 97.82
+	Hs
		438336 UN45B_HUMAN (75-276): 2.24e-41: 157: 23.08		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Mm
		513680 PPP5_MOUSE (63-268): 6.6e-41: 152: 16.51		HS90B_MOUSE (19-732): 0: 1063: 86.98
+	Hs
		438136 FKBP5_HUMAN (10-255): 2.21e-42: 155: 17.56		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Hs
		438021 PPP5_HUMAN (63-268): 4.43e-41: 153: 16.99		HS90B_HUMAN (19-732): 0: 1059: 86.13
+	Sc
		366048 CNS1_YEAST (23-358): 5e-41: 150: 22.06		HSP82_YEAST (16-732): 0: 907: 60.08
+	Mm
		435924 PPP5_MOUSE (63-268): 6.6e-41: 152: 16.51		ENPL_MOUSE (14-732): 0: 901: 45.07
+	Sc
		543468 CNS1_YEAST (23-358): 5e-41: 150: 22.06		HSC82_YEAST (16-732): 0: 902: 59.39
+	Hs
		323417 TTC4_HUMAN (1-387): 1.31e-88: 274: 100.00		H90B3_HUMAN (19-732): 0: 728: 65.41
+	Hs
		1123420 UN45B_HUMAN (75-276): 2.24e-41: 157: 23.08		H90B4_HUMAN (30-604): 0: 571: 62.61
+	Hs
		858632 PPP5_HUMAN (63-268): 4.43e-41: 153: 16.99		H90B4_HUMAN (30-604): 0: 571: 62.61