HitPredict

Interactor 1: SLIK5 (O94991)
SLIT and NTRK-like protein 5 (Leucine-rich repeat-containing protein 11)
Gene: SLITRK5

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	39499777
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GF_recep_IV~LRR_8, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 958 Hs			1 1210
+	Hs
		324324 SLIK5_HUMAN (1-958): 4.84e-167: 515: 100.00		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		322525 SLIK3_HUMAN (14-953): 6.6e-108: 359: 38.93		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		363534 SLIK4_HUMAN (22-958): 1.46e-100: 335: 39.70		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		322527 SLIK3_HUMAN (14-953): 6.6e-108: 359: 38.93		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		363825 RTN4R_HUMAN (370-660): 3.22e-60: 215: 21.63		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		410931 SLIK4_HUMAN (22-958): 1.46e-100: 335: 39.70		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	Hs
		363511 LRRT4_HUMAN (47-339): 6.65e-49: 185: 17.72		EGFR_HUMAN (1-1210): 0: 1246: 100.00
+	Hs
		411039 RTN4R_HUMAN (370-660): 3.22e-60: 215: 21.63		ERBB2_HUMAN (5-1203): 0: 1119: 48.38
+	At
		1441449 RGI1_ARATH (324-868): 3.27e-50: 195: 11.80		TMK3_ARATH (349-984): 1.3e-141: 455: 16.19
+	At
		1456490 Y1723_ARATH (2-336): 1.96e-43: 173: 16.81		TMK3_ARATH (349-984): 1.3e-141: 455: 16.19
+	At
		99913 MIK2_ARATH (275-830): 3.09e-50: 194: 11.83		F4I065_ARATH (409-1003): 1.14e-132: 429: 15.30
+	At
		1427569 RGI1_ARATH (324-868): 3.27e-50: 195: 11.80		TMK2_ARATH (352-961): 4.13e-132: 427: 17.66
+	At
		88726 RGI1_ARATH (324-868): 3.27e-50: 195: 11.80		Y4245_ARATH (439-1004): 2.04e-130: 423: 13.73
+	At
		847371 Y1723_ARATH (2-336): 1.96e-43: 173: 16.81		TMK1_ARATH (351-984): 1.3e-137: 444: 16.19
+	At
		1427647 EMS1_ARATH (348-957): 4.38e-45: 178: 11.40		Y5181_ARATH (413-977): 9.85e-131: 423: 14.43
+	At
		1427580 Y1723_ARATH (2-336): 1.96e-43: 173: 16.81		TMK2_ARATH (352-961): 4.13e-132: 427: 17.66
+	At
		88738 Y1723_ARATH (2-336): 1.96e-43: 173: 16.81		Y4245_ARATH (439-1004): 2.04e-130: 423: 13.73
+	At
		89303 RGI2_ARATH (192-742): 5.31e-40: 162: 10.12		F4I065_ARATH (409-1003): 1.14e-132: 429: 15.30
+	At
		1192457 ERECT_ARATH (354-793): 5.97e-40: 162: 13.45		IOS1_ARATH (388-1003): 7.97e-132: 427: 15.80
+	At
		1422675 FLS2_ARATH (3-282): 5.1e-39: 159: 19.08		IOS1_ARATH (388-1003): 7.97e-132: 427: 15.80