HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	35027733
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~Pkinase, Pkinase~Pkinase_C, Pkinase~UBA
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0006468 - protein phosphorylation GO:0106310 - protein serine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 1130
+	Hs
		325808 MINK1_HUMAN (1-1239): 0: 1120: 59.29		LATS1_HUMAN (1-1130): 0: 934: 100.00
+	Mm
		956972 M4K4_MOUSE (1-1239): 0: 1142: 88.17		AKT3_MOUSE (603-1081): 1.33e-142: 439: 24.54
+	Mm
		682106 M4K4_MOUSE (1-1239): 0: 1142: 88.17		AKT1_MOUSE (595-1081): 6.22e-141: 435: 24.50
+	Mm
		956961 M4K4_MOUSE (1-1239): 0: 1142: 88.17		AKT2_MOUSE (603-1081): 2.58e-139: 431: 25.81
+	Mm
		933105 TNIK_MOUSE (1-1239): 0: 1120: 62.43		KAPCB_MOUSE (661-1056): 2.81e-133: 410: 32.25
+	Mm
		397209 TNIK_MOUSE (1-1239): 0: 1120: 62.43		KAPCA_MOUSE (661-1056): 5.3e-133: 409: 31.25
+	Hs
		568827 TNIK_HUMAN (1-1239): 0: 1101: 60.56		KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59
+	Mm
		1207481 MARK4_MOUSE (16-693): 1.14e-122: 399: 17.92		LATS1_MOUSE (1-1130): 0: 922: 93.10
+	Hs
		149340 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		LATS2_HUMAN (13-1121): 0: 751: 49.61
+	Dm
		1182605 Q7KV89_DROME (3-813): 4.51e-117: 393: 40.32		WARTS_DROME (161-1065): 1.96e-152: 486: 39.48
+	Hs
		568839 SIK3_HUMAN (7-915): 2.5e-127: 426: 15.13		KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59
+	Hs
		681985 MARK4_HUMAN (16-693): 2.51e-123: 400: 18.06		AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50
+	Hs
		681915 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50
+	Hs
		568551 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59
+	Hs
		682218 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54
+	Hs
		681681 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50
+	Mm
		682096 AKT1_MOUSE (2-354): 1.36e-122: 389: 20.82		AKT1_MOUSE (595-1081): 6.22e-141: 435: 24.50
+	Hs
		681680 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50
+	Hs
		568714 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59
+	Hs
		568561 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59