HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: EPHA1 (P21709)
Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
Gene: EPHA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~fn3, PK_Tyr_Ser-Thr~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005524 - ATP binding GO:0030335 - positive regulation of cell migration
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1239 Hs			1 976
+	Hs
		324761 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA5_HUMAN (3-975): 0: 1117: 41.91
+	Hs
		324809 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA7_HUMAN (2-975): 0: 1117: 43.22
+	Hs
		324742 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHB2_HUMAN (27-975): 0: 1112: 41.01
+	Hs
		324762 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA4_HUMAN (5-975): 0: 1108: 43.50
+	Hs
		1072547 MINK1_HUMAN (1-1239): 0: 1120: 59.29		EPHA7_HUMAN (2-975): 0: 1117: 43.22
+	Hs
		872460 MINK1_HUMAN (1-1239): 0: 1120: 59.29		EPHA5_HUMAN (3-975): 0: 1117: 41.91
+	Hs
		1072625 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EPHA7_HUMAN (2-975): 0: 1117: 43.22
+	Hs
		872502 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EPHA5_HUMAN (3-975): 0: 1117: 41.91
+	Hs
		665680 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EPHB2_HUMAN (27-975): 0: 1112: 41.01
+	Hs
		324720 M4K4_HUMAN (1-1239): 0: 1227: 100.00		IGF1R_HUMAN (269-885): 5.75e-137: 446: 21.38
+	Hs
		647831 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		EPHB2_HUMAN (27-975): 0: 1112: 41.01
+	Hs
		600512 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		EPHA1_HUMAN (1-976): 0: 1103: 100.00
+	Hs
		1072635 M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52		EPHA7_HUMAN (2-975): 0: 1117: 43.22
+	Hs
		872510 M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52		EPHA5_HUMAN (3-975): 0: 1117: 41.91
+	Hs
		324795 M4K4_HUMAN (1-1239): 0: 1227: 100.00		FAK1_HUMAN (630-884): 1.18e-63: 236: 45.88
+	Hs
		665151 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		EPHA2_HUMAN (24-976): 0: 1056: 49.90
+	Hs
		435552 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		IGF1R_HUMAN (269-885): 5.75e-137: 446: 21.38
+	Mm
		546263 AKT1_MOUSE (2-354): 1.36e-122: 389: 20.82		INSR_MOUSE (387-882): 4.57e-130: 427: 26.40
+	Hs
		987310 M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52		TYRO3_HUMAN (276-964): 4.07e-145: 456: 23.98