Protein: RAB8A
Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)

Gene: RAB8A
Organism: Homo sapiens
Interactions: 198
UniProt ID: P61006

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955988

SYTL4
Synaptotagmin-like protein 4

9

12

Small-scale

0.970

High

724456

GDIA
Rab GDP dissociation inhibitor alpha

6

20

Small-scale

0.949

High

955993

RAB3I
Rab-3A-interacting protein

6

3

Small-scale

0.947

High

866371

MSS4
Guanine nucleotide exchange factor MSS4

5

9

Small-scale

0.922

High

894521

GDIB
Rab GDP dissociation inhibitor beta

5

20

Small-scale

0.919

High

955919

OCRL
Inositol polyphosphate 5-phosphatase OCRL

4

9

Small-scale

0.913

High

955985

RAB8B
Ras-related protein Rab-8B

4

17

Small-scale

0.892

High

955910

RAB1A
Ras-related protein Rab-1A

3

18

Small-scale

0.855

High

955975

R3GEF
Guanine nucleotide exchange factor for Rab-3A

3

3

Small-scale

0.849

High

955941

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

9

Small-scale

0.839

High

955986

RIPL2
RILP-like protein 2

2

6

Small-scale

0.825

High

955929

RB39A
Ras-related protein Rab-39A

3

20

Small-scale

0.818

High

955961

MILK2
MICAL-like protein 2

3

20

Small-scale

0.818

High

956029

RP3A
Rabphilin-3A

2

12

High-throughput

0.811

High

955951

MICA3
[F-actin]-monooxygenase MICAL3

3

20

Small-scale

0.802

High

955903

RAB10
Ras-related protein Rab-10

2

17

High-throughput

0.776

High

955940

RIPL1
RILP-like protein 1

2

10

Small-scale

0.767

High

956026

MYO5B
Unconventional myosin-Vb

2

9

Small-scale

0.757

High

955904

RAB14
Ras-related protein Rab-14

2

19

High-throughput

0.754

High

955989

OPTN
Optineurin

7

18

Small-scale

0.744

High

955922

TBC8B
TBC1 domain family member 8B

2

14

Small-scale

0.735

High

955965

MILK1
MICAL-like protein 1

2

20

Small-scale

0.735

High

955977

MICA1
[F-actin]-monooxygenase MICAL1

2

20

Small-scale

0.735

High

955923

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

9

Small-scale

0.713

High

731949

I5P2
Type II inositol 1,4,5-trisphosphate 5-phosphatase

2

9

Small-scale

0.712

High

955956

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.691

High

956009

TBC17
TBC1 domain family member 17

1

19

Small-scale

0.691

High

956034

SRPRB
Signal recognition particle receptor subunit beta

3

19

High-throughput

0.667

High

856621

BAG6
Large proline-rich protein BAG6

3

7

Small-scale

0.658

High

955943

TBC9B
TBC1 domain family member 9B

2

15

Small-scale

0.658

High

902181

RAB13
Ras-related protein Rab-13

1

17

Small-scale

0.647

High

955907

RB11A
Ras-related protein Rab-11A

1

18

Small-scale

0.647

High

955927

SQSTM
Sequestosome-1

3

6

Small-scale

0.640

High

845002

EAA3
Excitatory amino acid transporter 3

2

3

High-throughput

0.628

High

955964

EH1L1
EH domain-binding protein 1-like protein 1

1

20

Small-scale

0.625

High

955971

EHBP1
EH domain-binding protein 1

1

20

Small-scale

0.625

High

390515

TFR1
Transferrin receptor protein 1

2

1

Small-scale

0.624

High

956013

MYO5C
Unconventional myosin-Vc

1

9

Small-scale

0.621

High

126530

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

349021

LATS1
Serine/threonine-protein kinase LATS1

1

4

High-throughput

0.618

High

400574

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.618

High

466179

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

538923

EPB41
Protein 4.1

1

5

High-throughput

0.618

High

541421

FGFR1
Fibroblast growth factor receptor 1

1

5

Small-scale

0.618

High

580963

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601226

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

630485

RAB3B
Ras-related protein Rab-3B

1

17

Small-scale

0.618

High

711859

LTK
Leukocyte tyrosine kinase receptor

1

14

High-throughput

0.618

High

909994

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

953372

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955005

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

955902

RAB8A
Ras-related protein Rab-8A

1

18

High-throughput

0.618

High

955905

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

955909

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

955911

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

955915

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

955924

STK4
Serine/threonine-protein kinase 4

1

8

High-throughput

0.618

High

955933

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

955936

DDR2
Discoidin domain-containing receptor 2

1

16

High-throughput

0.618

High

955949

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

955960

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.618

High

955987

MIB2
E3 ubiquitin-protein ligase MIB2

1

3

Small-scale

0.618

High

955992

FMNL2
Formin-like protein 2

1

5

High-throughput

0.618

High

956002

RB33B
Ras-related protein Rab-33B

1

19

High-throughput

0.618

High

956004

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

956011

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

956015

LATS2
Serine/threonine-protein kinase LATS2

1

4

High-throughput

0.618

High

956021

PD1L1
Programmed cell death 1 ligand 1

1

13

Small-scale

0.618

High

956023

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.618

High

955974

EXOC6
Exocyst complex component 6

2

2

Small-scale

0.611

High

243917

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

2

10

Small-scale

0.588

High

588352

RFA2
Replication protein A 32 kDa subunit

2

7

High-throughput

0.584

High

695083

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

8

High-throughput

0.584

High

767841

RFA3
Replication protein A 14 kDa subunit

2

5

High-throughput

0.584

High

159586

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

2

Small-scale

0.575

High

631633

RAB6A
Ras-related protein Rab-6A

1

19

Small-scale

0.575

High

664854

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

20

Small-scale

0.575

High

686567

RAE2
Rab proteins geranylgeranyltransferase component A 2

1

20

Small-scale

0.575

High

955932

ACAP2
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

1

4

Small-scale

0.575

High

955966

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.575

High

956003

RAB6C
Ras-related protein Rab-6C

1

18

Small-scale

0.575

High

956012

RAB18
Ras-related protein Rab-18

1

19

Small-scale

0.575

High

956036

STK24
Serine/threonine-protein kinase 24

1

6

Small-scale

0.575

High

62050

WDR91
WD repeat-containing protein 91

2

4

Small-scale

0.570

High

955937

WDR81
WD repeat-containing protein 81

2

7

Small-scale

0.570

High

955957

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

9

Small-scale

0.559

High

955948

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.553

High

137208

EXOC5
Exocyst complex component 5

1

1

High-throughput

0.536

High

690219

STOM
Stomatin

1

5

High-throughput

0.536

High

866956

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

955916

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.536

High

955991

CI072
Guanine nucleotide exchange factor C9orf72

1

2

Small-scale

0.536

High

956030

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.536

High

956032

SAM50
Sorting and assembly machinery component 50 homolog

1

1

High-throughput

0.536

High

573416

ENPL
Endoplasmin

1

5

High-throughput

0.515

High

955976

TBC15
TBC1 domain family member 15

1

19

Small-scale

0.514

High

955946

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

955973

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.513

High

956016

CENPM
Centromere protein M

1

0

High-throughput

0.513

High

956019

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.513

High

955939

ODFP2
Outer dense fiber protein 2

1

0

Small-scale

0.504

High

955963

SYTL1
Synaptotagmin-like protein 1

1

11

Small-scale

0.501

High

956037

NEMO
NF-kappa-B essential modulator

1

16

Small-scale

0.501

High

955918

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.500

High

956035

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.489

High

164299

NRP1
Neuropilin-1

1

5

High-throughput

0.479

High

176959

CE290
Centrosomal protein of 290 kDa

1

11

Small-scale

0.479

High

194816

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

2

Small-scale

0.479

High

208488

PJA2
E3 ubiquitin-protein ligase Praja-2

1

12

Small-scale

0.479

High

324696

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

345589

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

370617

FOS
Protein c-Fos

1

4

High-throughput

0.479

High

403943

GCR
Glucocorticoid receptor

1

12

High-throughput

0.479

High

488759

FURIN
Furin

1

2

High-throughput

0.479

High

543123

UBL4A
Ubiquitin-like protein 4A

1

16

High-throughput

0.479

High

560349

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

774256

BASI
Basigin

1

7

High-throughput

0.479

High

791237

SYUA
Alpha-synuclein

1

7

Small-scale

0.479

High

872132

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

878862

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.479

High

883197

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

6

High-throughput

0.479

High

942521

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

4

High-throughput

0.479

High

955906

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.479

High

955912

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

955917

VIGLN
Vigilin

1

1

High-throughput

0.479

High

955921

CALD1
Caldesmon

1

12

High-throughput

0.479

High

955925

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

10

High-throughput

0.479

High

955926

STX3
Syntaxin-3

1

8

Small-scale

0.479

High

955928

DCTN1
Dynactin subunit 1

1

4

High-throughput

0.479

High

955930

TNIP1
TNFAIP3-interacting protein 1

1

16

High-throughput

0.479

High

955934

VAMP3
Vesicle-associated membrane protein 3

1

11

Small-scale

0.479

High

955942

CP135
Centrosomal protein of 135 kDa

1

2

High-throughput

0.479

High

955944

FMN1
Formin-1

1

5

High-throughput

0.479

High

955945

CDC73
Parafibromin

1

3

High-throughput

0.479

High

955947

RBP10
Ran-binding protein 10

1

2

High-throughput

0.479

High

955950

MAEA
E3 ubiquitin-protein transferase MAEA

1

5

High-throughput

0.479

High

955953

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

955954

CNTRL
Centriolin

1

5

High-throughput

0.479

High

955958

CEP97
Centrosomal protein of 97 kDa

1

6

High-throughput

0.479

High

955968

POC5
Centrosomal protein POC5

1

1

High-throughput

0.479

High

955969

RN149
E3 ubiquitin-protein ligase RNF149

1

14

High-throughput

0.479

High

955972

FLCN
Folliculin

1

3

Small-scale

0.479

High

955978

SMCR8
Guanine nucleotide exchange protein SMCR8

1

2

Small-scale

0.479

High

955980

CLC4D
C-type lectin domain family 4 member D

1

9

High-throughput

0.479

High

955981

RFFL
E3 ubiquitin-protein ligase rififylin

1

6

Small-scale

0.479

High

955983

AKAP1
A-kinase anchor protein 1, mitochondrial

1

5

High-throughput

0.479

High

955990

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

4

High-throughput

0.479

High

955994

RANB9
Ran-binding protein 9

1

2

High-throughput

0.479

High

955995

KIF2C
Kinesin-like protein KIF2C

1

3

Small-scale

0.479

High

956000

FACD2
Fanconi anemia group D2 protein

1

10

High-throughput

0.479

High

956001

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

6

Small-scale

0.479

High

956006

RNF41
E3 ubiquitin-protein ligase NRDP1

1

6

Small-scale

0.479

High

956007

WDR26
WD repeat-containing protein 26

1

5

High-throughput

0.479

High

956008

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

4

High-throughput

0.479

High

956014

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

6

Small-scale

0.479

High

956018

GID8
Glucose-induced degradation protein 8 homolog

1

5

High-throughput

0.479

High

956020

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

6

High-throughput

0.479

High

956027

CLC4E
C-type lectin domain family 4 member E

1

9

High-throughput

0.479

High

956028

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

11

Small-scale

0.479

High

955908

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.458

High

955959

LAX1
Lymphocyte transmembrane adapter 1

1

0

Small-scale

0.458

High

955962

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.458

High

955997

TALD3
Protein TALPID3

1

0

Small-scale

0.458

High

956010

CYBP
Calcyclin-binding protein

1

0

Small-scale

0.458

High

956024

MKLN1
Muskelin

1

0

High-throughput

0.458

High

956031

RIPR2
Rho family-interacting cell polarization regulator 2

1

0

High-throughput

0.458

High

955998

KLF16
Krueppel-like factor 16

1

3

High-throughput

0.457

High

321215

ERLN2
Erlin-2

1

7

Small-scale

0.445

High

612183

ARF4
ADP-ribosylation factor 4

1

19

Small-scale

0.445

High

827157

ARL1
ADP-ribosylation factor-like protein 1

1

20

Small-scale

0.445

High

921527

PGTB2
Geranylgeranyl transferase type-2 subunit beta

1

2

Small-scale

0.445

High

955913

ARF1
ADP-ribosylation factor 1

1

18

Small-scale

0.445

High

955914

ARF5
ADP-ribosylation factor 5

1

18

Small-scale

0.445

High

955931

S39AE
Metal cation symporter ZIP14

1

6

High-throughput

0.445

High

955967

CD177
CD177 antigen

1

5

Small-scale

0.445

High

955970

MOT11
Monocarboxylate transporter 11

1

7

High-throughput

0.445

High

955982

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

9

Small-scale

0.445

High

955984

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

8

Small-scale

0.445

High

955996

ESYT1
Extended synaptotagmin-1

1

6

Small-scale

0.445

High

955999

S12A9
Solute carrier family 12 member 9

1

10

High-throughput

0.445

High

956005

EHD1
EH domain-containing protein 1

1

6

Small-scale

0.445

High

956017

ARL8B
ADP-ribosylation factor-like protein 8B

1

18

Small-scale

0.445

High

956022

VAPA
Vesicle-associated membrane protein-associated protein A

1

4

Small-scale

0.445

High

956025

PPM1H
Protein phosphatase 1H

1

5

Small-scale

0.445

High

257233

PQBP1
Polyglutamine-binding protein 1

1

0

High-throughput

0.438

High

105674

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

418044

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

5

High-throughput

0.437

High

955952

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

955955

GOLI
E3 ubiquitin-protein ligase RNF130

1

15

High-throughput

0.437

High

283227

ERLN1
Erlin-1

1

1

Small-scale

0.407

High

955920

TAGL
Transgelin

1

3

High-throughput

0.407

High

333646

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.279

Low

955935

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

High-throughput

0.279

Low

955979

SSMM1
Serine-rich single-pass membrane protein 1

1

0

High-throughput

0.279

Low

84336

B6ZDN3
Doublecortin domain containing 1

1

0

Small-scale

0.261

Low

955938

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.249

Low

956033

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025