HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: RIMS1 (Q86UR5)
Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2)
Gene: RIMS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.50	0.407

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1239 Hs			1 1692
+	Hs
		1200021 TNIK_HUMAN (1-1239): 0: 1101: 60.56		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Hs
		324819 M4K4_HUMAN (1-1239): 0: 1227: 100.00		SYT6_HUMAN (435-887): 1.53e-54: 201: 15.34
+	Hs
		647919 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Hs
		1183065 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		RIMS1_HUMAN (1-1692): 0: 972: 100.00
+	Mm
		949283 TNIK_MOUSE (1-1239): 0: 1120: 62.43		UN13A_MOUSE (756-1691): 1.05e-59: 229: 11.72
+	Mm
		93268 TNIK_MOUSE (1-1239): 0: 1120: 62.43		E9PXB7_MOUSE (863-1341): 1.02e-57: 218: 15.25
+	Hs
		324844 M4K4_HUMAN (1-1239): 0: 1227: 100.00		SYT2_HUMAN (733-889): 2e-17: 88.8: 23.57
+	Mm
		808345 TNIK_MOUSE (1-1239): 0: 1120: 62.43		NEDD4_MOUSE (1510-1687): 1.31e-30: 133: 18.92
+	Hs
		1233533 MINK1_HUMAN (1-1239): 0: 1120: 59.29		NED4L_HUMAN (1535-1687): 4.67e-28: 125: 21.12
+	Mm
		949373 TNIK_MOUSE (1-1239): 0: 1120: 62.43		NED4L_MOUSE (1525-1687): 9.27e-28: 124: 20.71
+	Hs
		1356429 TNIK_HUMAN (1-1239): 0: 1101: 60.56		PCLO_HUMAN (1446-1666): 1.18e-29: 131: 21.37
+	Mm
		949403 TNIK_MOUSE (1-1239): 0: 1120: 62.43		RIMS1_MOUSE (192-869): 2.03e-17: 91.2: 13.95
+	Hs
		148967 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		SYT10_HUMAN (421-896): 6.81e-48: 182: 17.22
+	Hs
		131575 STK25_HUMAN (14-452): 5.34e-114: 364: 34.99		SYT6_HUMAN (435-887): 1.53e-54: 201: 15.34
+	Hs
		149481 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		PCLO_HUMAN (1446-1666): 1.18e-29: 131: 21.37
+	Hs
		1183099 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		NED4L_HUMAN (1535-1687): 4.67e-28: 125: 21.12
+	Hs
		681988 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		NED4L_HUMAN (1535-1687): 4.67e-28: 125: 21.12
+	Hs
		128938 STK24_HUMAN (20-398): 2.05e-110: 355: 36.65		P3C2A_HUMAN (1538-1664): 1.27e-23: 111: 27.48