HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: ZRAN1 (Q9UGI0)
Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1)
Gene: ZRANB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	33853758, 35944360, 19615732
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1239 Hs			1 708
+	Hs
		647974 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		ZRAN1_HUMAN (1-697): 0: 987: 100.00
+	Hs
		1183142 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		ZRAN1_HUMAN (1-697): 0: 987: 100.00
+	Hs
		1025233 AAPK1_HUMAN (8-555): 9.95e-123: 392: 16.85		ZRAN1_HUMAN (1-697): 0: 987: 100.00
+	Hs
		682057 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		ZRAN1_HUMAN (1-697): 0: 987: 100.00
+	Hs
		1217591 M4K3_HUMAN (17-386): 8.8e-111: 370: 41.44		ZRAN1_HUMAN (1-697): 0: 987: 100.00
+	Hs
		254521 ROCK2_HUMAN (15-536): 8.84e-107: 369: 22.02		ZRAN1_HUMAN (1-697): 0: 987: 100.00
+	Hs
		1354989 M4K5_HUMAN (4-375): 4.65e-107: 359: 39.52		ZRAN1_HUMAN (1-697): 0: 987: 100.00
+	Hs
		1350178 STK26_HUMAN (16-414): 6.13e-111: 355: 34.05		ZRAN1_HUMAN (1-697): 0: 987: 100.00
+	Hs
		1150625 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		RNF31_HUMAN (29-410): 7.77e-78: 271: 15.73
+	Hs
		599620 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		TNAP3_HUMAN (392-651): 2.48e-93: 308: 35.74
+	Hs
		599757 STK24_HUMAN (20-398): 2.05e-110: 355: 36.65		TNAP3_HUMAN (392-651): 2.48e-93: 308: 35.74
+	Hs
		1023092 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		RNF31_HUMAN (29-410): 7.77e-78: 271: 15.73
+	Hs
		148540 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		RBP2_HUMAN (35-380): 3.46e-21: 101: 9.86
+	Hs
		834728 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		RBP2_HUMAN (35-380): 3.46e-21: 101: 9.86
+	Hs
		148539 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		NU153_HUMAN (109-348): 5.07e-09: 61.9: 11.11