HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: CTTB2 (Q8WZ74)
Cortactin-binding protein 2 (CortBP2)
Gene: CTTNBP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	32640226
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Pkinase, Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 1663
+	Hs
		1264914 TNIK_HUMAN (1-1239): 0: 1101: 60.56		CTTB2_HUMAN (1-1663): 0: 1226: 100.00
+	Mm
		82720 TNIK_MOUSE (1-1239): 0: 1120: 62.43		CTTB2_MOUSE (1-1663): 0: 1182: 83.89
+	Hs
		324896 M4K4_HUMAN (1-1239): 0: 1227: 100.00		CT2NL_HUMAN (32-597): 1.61e-94: 322: 39.00
+	Hs
		310105 TNIK_HUMAN (1-1239): 0: 1101: 60.56		TNKS1_HUMAN (714-1334): 1.19e-105: 371: 12.35
+	Hs
		1233557 MINK1_HUMAN (1-1239): 0: 1120: 59.29		CT2NL_HUMAN (32-597): 1.61e-94: 322: 39.00
+	Hs
		1350214 TNIK_HUMAN (1-1239): 0: 1101: 60.56		CT2NL_HUMAN (32-597): 1.61e-94: 322: 39.00
+	Mm
		949370 TNIK_MOUSE (1-1239): 0: 1120: 62.43		ANK2_MOUSE (553-1160): 6.05e-71: 267: 14.99
+	Hs
		965172 TNIK_HUMAN (1-1239): 0: 1101: 60.56		ANK2_HUMAN (553-1160): 5.69e-71: 267: 14.99
+	Hs
		1356406 TNIK_HUMAN (1-1239): 0: 1101: 60.56		ANR50_HUMAN (824-1284): 1.25e-56: 219: 9.85
+	Mm
		103596 TNIK_MOUSE (1-1239): 0: 1120: 62.43		ANK3_MOUSE (1146-1275): 1.46e-17: 91.7: 9.63
+	Hs
		1021472 TNIK_HUMAN (1-1239): 0: 1101: 60.56		ANK3_HUMAN (1119-1275): 3.91e-20: 100: 6.17
+	Hs
		1027448 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		CT2NL_HUMAN (32-597): 1.61e-94: 322: 39.00
+	Hs
		1023131 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		CT2NL_HUMAN (32-597): 1.61e-94: 322: 39.00
+	Hs
		1239487 BRSK1_HUMAN (22-753): 9.31e-120: 391: 17.08		ANR52_HUMAN (579-1141): 5.87e-72: 265: 14.48
+	Hs
		647851 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		DAPK1_HUMAN (916-1286): 1.62e-20: 101: 9.52
+	Hs
		1027432 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		Q9H4D1_HUMAN (627-829): 4.61e-29: 128: 24.53
+	Hs
		883501 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		RIPK4_HUMAN (627-829): 4.95e-29: 128: 24.53
+	Hs
		862065 MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10		DAPK1_HUMAN (916-1286): 1.62e-20: 101: 9.52
+	Hs
		166980 BRSK1_HUMAN (22-753): 9.31e-120: 391: 17.08		ANR28_HUMAN (602-831): 5.29e-21: 102: 16.88
+	Hs
		647932 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		ASB13_HUMAN (636-846): 1.93e-12: 71.6: 31.63