HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: PHOCN (Q9Y3A3)
MOB-like protein phocein (2C4D) (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3)
Gene: MOB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	32640226
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 225
+	Hs
		324837 M4K4_HUMAN (1-1239): 0: 1227: 100.00		MOB3B_HUMAN (20-212): 5.12e-91: 268: 20.40
+	Hs
		324883 M4K4_HUMAN (1-1239): 0: 1227: 100.00		MOB1A_HUMAN (17-212): 4.06e-89: 263: 20.10
+	Hs
		324861 M4K4_HUMAN (1-1239): 0: 1227: 100.00		MOB3A_HUMAN (20-212): 1.4e-88: 261: 18.91
+	Hs
		324831 M4K4_HUMAN (1-1239): 0: 1227: 100.00		MOB3C_HUMAN (19-217): 1.08e-87: 259: 17.87
+	Hs
		324833 M4K4_HUMAN (1-1239): 0: 1227: 100.00		MOB1B_HUMAN (19-212): 8.58e-88: 259: 20.30
+	Hs
		1233571 MINK1_HUMAN (1-1239): 0: 1120: 59.29		PHOCN_HUMAN (1-225): 8.34e-111: 318: 100.00
+	Mm
		949324 TNIK_MOUSE (1-1239): 0: 1120: 62.43		PHOCN_MOUSE (1-225): 8.34e-111: 318: 100.00
+	Hs
		1356420 TNIK_HUMAN (1-1239): 0: 1101: 60.56		PHOCN_HUMAN (1-225): 8.34e-111: 318: 100.00
+	Hs
		1198329 MINK1_HUMAN (1-1239): 0: 1120: 59.29		MOB3B_HUMAN (20-212): 5.12e-91: 268: 20.40
+	Hs
		1174260 MINK1_HUMAN (1-1239): 0: 1120: 59.29		MOB3C_HUMAN (19-217): 1.08e-87: 259: 17.87
+	Hs
		1027459 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		PHOCN_HUMAN (1-225): 8.34e-111: 318: 100.00
+	Dm
		1178592 Q7KV89_DROME (3-813): 4.51e-117: 393: 40.32		MOB4_DROME (1-225): 1.36e-105: 305: 80.00
+	Hs
		1023145 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		PHOCN_HUMAN (1-225): 8.34e-111: 318: 100.00
+	Hs
		131625 STK25_HUMAN (14-452): 5.34e-114: 364: 34.99		PHOCN_HUMAN (1-225): 8.34e-111: 318: 100.00
+	Dm
		1178607 Q9VEN3_DROME (20-340): 7.49e-112: 366: 42.72		MOB4_DROME (1-225): 1.36e-105: 305: 80.00
+	Hs
		1027394 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MOB3B_HUMAN (20-212): 5.12e-91: 268: 20.40
+	Hs
		1027437 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MOB1A_HUMAN (17-212): 4.06e-89: 263: 20.10
+	Hs
		1023117 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		MOB1A_HUMAN (17-212): 4.06e-89: 263: 20.10
+	Hs
		1027391 STK3_HUMAN (4-499): 3.17e-119: 381: 30.60		MOB1B_HUMAN (19-212): 8.58e-88: 259: 20.30
+	Hs
		1023070 STK4_HUMAN (4-517): 8.55e-119: 379: 31.92		MOB1B_HUMAN (19-212): 8.58e-88: 259: 20.30