HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20841485
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 724
+	Hs
		438558 LATS2_HUMAN (13-1121): 0: 751: 49.61		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		432293 LATS2_HUMAN (13-1121): 0: 751: 49.61		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438637 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438188 STK38_HUMAN (622-1089): 5.96e-165: 497: 40.17		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		432381 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431870 STK38_HUMAN (622-1089): 5.96e-165: 497: 40.17		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438633 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Mm
		513660 AKT1_MOUSE (595-1081): 6.22e-141: 435: 24.50		HS90B_MOUSE (1-724): 0: 1089: 99.59
+	Bt
		964601 AKT1_BOVIN (595-1081): 3.57e-142: 439: 24.70		HS90B_BOVIN (1-724): 0: 1085: 99.59
+	Hs
		432376 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431572 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Rn
		812703 AKT1_RAT (595-1081): 5.48e-141: 435: 24.50		HS90A_RAT (1-724): 0: 1070: 84.45
+	Mm
		432411 AKT1_MOUSE (595-1081): 6.22e-141: 435: 24.50		HS90A_MOUSE (1-724): 0: 1068: 84.31
+	Sc
		366698 CBK1_YEAST (397-1091): 2.99e-167: 514: 30.07		HSP82_YEAST (12-724): 0: 927: 61.26
+	Sc
		544196 CBK1_YEAST (397-1091): 2.99e-167: 514: 30.07		HSC82_YEAST (13-724): 0: 922: 60.22
+	Sc
		365836 KPC1_YEAST (45-1086): 3.02e-152: 486: 15.15		HSP82_YEAST (12-724): 0: 927: 61.26
+	Hs
		538446 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Hs
		1123464 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		H90B3_HUMAN (1-724): 0: 815: 75.83
+	Hs
		1123447 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		H90B4_HUMAN (25-596): 0: 639: 71.85
+	Hs
		1162538 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		Q6PK50_HUMAN (1-350): 0: 618: 99.71