HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	28420424, 26840256
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 759
+	Hs
		325720 LATS1_HUMAN (1-1130): 0: 934: 100.00		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		325719 LATS1_HUMAN (1-1130): 0: 934: 100.00		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		568656 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1035170 ROCK1_HUMAN (694-1046): 9.23e-66: 245: 39.94		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1041287 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		681835 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		682174 AKT2_HUMAN (603-1075): 3.93e-140: 433: 25.31		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		1035169 ROCK1_HUMAN (694-1046): 9.23e-66: 245: 39.94		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		254479 ROCK2_HUMAN (694-1046): 2.95e-63: 238: 38.27		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1042944 MRCKB_HUMAN (695-1047): 8.47e-63: 236: 38.06		CUL3_HUMAN (32-759): 0: 814: 38.23