HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: GRDN (Q3V6T2)
Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)
Gene: CCDC88A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 35941108
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 1871
+	Hs
		325955 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH4_HUMAN (5-707): 1.9e-26: 121: 12.26
+	Hs
		325919 LATS1_HUMAN (1-1130): 0: 934: 100.00		DAPLE_HUMAN (862-1846): 6.94e-26: 119: 11.33
+	Hs
		325605 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH3_HUMAN (964-1722): 4.28e-25: 116: 10.69
+	Hs
		325612 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH8_HUMAN (8-679): 1.31e-23: 111: 11.72
+	Hs
		325936 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH13_HUMAN (49-679): 3.06e-21: 103: 10.35
+	Hs
		325611 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH6_HUMAN (1-400): 1.3e-10: 69.2: 12.47
+	Hs
		325609 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH7_HUMAN (1-391): 2.32e-10: 68.1: 12.25
+	Hs
		325608 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH1_HUMAN (1-392): 8.09e-09: 63.1: 10.94
+	Hs
		325935 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH2_HUMAN (1-392): 9.18e-09: 63.1: 10.69
+	Hs
		681881 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		GRDN_HUMAN (1-1871): 2.19e-149: 509: 100.00
+	Mm
		682109 AKT1_MOUSE (595-1081): 6.22e-141: 435: 24.50		GRDN_MOUSE (1-1871): 5.17e-145: 497: 94.77
+	Mm
		1130947 AKT2_MOUSE (603-1081): 2.58e-139: 431: 25.81		GRDN_MOUSE (1-1871): 5.17e-145: 497: 94.77
+	Hs
		1344953 LATS2_HUMAN (13-1121): 0: 751: 49.61		DAPLE_HUMAN (862-1846): 6.94e-26: 119: 11.33
+	Hs
		149340 LATS2_HUMAN (13-1121): 0: 751: 49.61		CTRO_HUMAN (144-645): 2.42e-16: 88.1: 16.63
+	Hs
		725079 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		681696 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		568567 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		568568 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		MYH10_HUMAN (43-620): 1.66e-20: 101: 9.86
+	Hs
		518814 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		TPR_HUMAN (1125-1868): 4.51e-19: 97: 12.93
+	Hs
		551616 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		DESP_HUMAN (244-1208): 1.11e-09: 66.2: 19.09