HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: CEP85 (Q6P2H3)
Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21)
Gene: CEP85

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000922 - spindle pole GO:0005813 - centrosome GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 762
+	Hs
		325935 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH2_HUMAN (485-762): 1.22e-14: 80.6: 10.79
+	Hs
		325612 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH8_HUMAN (485-762): 4.26e-13: 75.6: 11.51
+	Hs
		325936 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH13_HUMAN (170-663): 5.35e-13: 75: 12.07
+	Hs
		325758 LATS1_HUMAN (1-1130): 0: 934: 100.00		GRDN_HUMAN (340-687): 7.66e-13: 74.6: 20.46
+	Hs
		325919 LATS1_HUMAN (1-1130): 0: 934: 100.00		DAPLE_HUMAN (385-740): 2.37e-12: 73: 18.35
+	Hs
		325605 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH3_HUMAN (125-577): 7.63e-12: 71.4: 9.41
+	Hs
		1159103 LATS2_HUMAN (13-1121): 0: 751: 49.61		CEP85_HUMAN (1-762): 9.11e-72: 251: 100.00
+	Hs
		325611 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH6_HUMAN (115-496): 3.81e-10: 66: 7.21
+	Hs
		325609 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH7_HUMAN (110-485): 8.25e-10: 64.8: 7.32
+	Hs
		1344953 LATS2_HUMAN (13-1121): 0: 751: 49.61		DAPLE_HUMAN (385-740): 2.37e-12: 73: 18.35
+	Hs
		149340 LATS2_HUMAN (13-1121): 0: 751: 49.61		CTRO_HUMAN (260-622): 2.7e-09: 63.1: 14.80
+	Hs
		725079 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		MYH9_HUMAN (396-760): 3.11e-16: 85.6: 12.06
+	Sc
		446116 KPC1_YEAST (45-1086): 3.02e-152: 486: 15.15		MYO1_YEAST (344-750): 3.9e-13: 75.7: 19.29
+	Hs
		681696 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		MYH9_HUMAN (396-760): 3.11e-16: 85.6: 12.06
+	Hs
		681881 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		GRDN_HUMAN (340-687): 7.66e-13: 74.6: 20.46
+	Mm
		682109 AKT1_MOUSE (595-1081): 6.22e-141: 435: 24.50		GRDN_MOUSE (260-753): 1.5e-12: 73.8: 18.05
+	Hs
		681840 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		DCTN1_HUMAN (504-754): 1.94e-12: 73.2: 13.78
+	Hs
		568567 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		MYH9_HUMAN (396-760): 3.11e-16: 85.6: 12.06
+	Mm
		1130947 AKT2_MOUSE (603-1081): 2.58e-139: 431: 25.81		GRDN_MOUSE (260-753): 1.5e-12: 73.8: 18.05
+	Hs
		551616 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		DESP_HUMAN (383-734): 5.95e-10: 65.3: 17.34