HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: ASPP1 (Q96KQ4)
Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B)
Gene: PPP1R13B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	21041411, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 1090
+	Hs
		325722 LATS1_HUMAN (1-1130): 0: 934: 100.00		ASPP2_HUMAN (1-1090): 2e-141: 456: 46.13
+	Hs
		1296380 LATS2_HUMAN (13-1121): 0: 751: 49.61		ASPP1_HUMAN (1-1090): 1.25e-150: 479: 100.00
+	Hs
		325765 LATS1_HUMAN (1-1130): 0: 934: 100.00		TGO1_HUMAN (10-584): 5.07e-78: 283: 16.35
+	Hs
		1043761 LATS2_HUMAN (13-1121): 0: 751: 49.61		ASPP2_HUMAN (1-1090): 2e-141: 456: 46.13
+	Hs
		166871 LATS1_HUMAN (1-1130): 0: 934: 100.00		ANR28_HUMAN (709-1086): 2.22e-47: 186: 12.88
+	Hs
		325811 LATS1_HUMAN (1-1130): 0: 934: 100.00		ANR52_HUMAN (751-1080): 6.18e-45: 178: 14.04
+	Hs
		1127324 LATS2_HUMAN (13-1121): 0: 751: 49.61		TGO1_HUMAN (10-584): 5.07e-78: 283: 16.35
+	Hs
		161275 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYPT1_HUMAN (821-1021): 1.28e-14: 81.1: 24.27
+	Hs
		1069637 STK38_HUMAN (622-1089): 5.96e-165: 497: 40.17		EHMT2_HUMAN (643-994): 1.76e-30: 132: 12.47
+	Mm
		69925 B1B1A8_MOUSE (38-1023): 1.41e-146: 486: 16.30		MYPT1_MOUSE (821-1021): 3.58e-14: 79.5: 22.82
+	Hs
		1137887 MRCKA_HUMAN (694-1047): 2.92e-66: 248: 39.06		DOT1L_HUMAN (94-844): 1.19e-72: 266: 16.97
+	Hs
		1035191 ROCK1_HUMAN (694-1046): 9.23e-66: 245: 39.94		ANR49_HUMAN (852-992): 1.66e-22: 99.5: 28.28
+	Hs
		254502 ROCK2_HUMAN (694-1046): 2.95e-63: 238: 38.27		ANR49_HUMAN (852-992): 1.66e-22: 99.5: 28.28
+	Hs
		161361 DMPK_HUMAN (671-1043): 4.83e-65: 234: 36.29		MYPT1_HUMAN (821-1021): 1.28e-14: 81.1: 24.27