Protein: CPSF1
Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)

Gene: CPSF1
Organism: Homo sapiens
Interactions: 203
UniProt ID: Q10570

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
GO:0006397 - mRNA processing
GO:0019899 - enzyme binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

340745

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

4

4

High-throughput

0.895

High

1083434

WDR33
pre-mRNA 3' end processing protein WDR33

4

18

Small-scale

0.860

High

775041

FUS
RNA-binding protein FUS

2

7

Small-scale

0.789

High

1083370

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

5

High-throughput

0.789

High

1083345

CSTF3
Cleavage stimulation factor subunit 3

2

5

Small-scale

0.768

High

1083423

RBM14
RNA-binding protein 14

2

0

Small-scale

0.748

High

1083439

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

1

Small-scale

0.715

High

1083389

FIP1
Pre-mRNA 3'-end-processing factor FIP1

4

2

Small-scale

0.698

High

1083433

GLIS2
Zinc finger protein GLIS2

1

3

Small-scale

0.698

High

1083455

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

4

8

Small-scale

0.694

High

478015

SNRPA
U1 small nuclear ribonucleoprotein A

1

8

High-throughput

0.691

High

889560

CLK2
Dual specificity protein kinase CLK2

1

4

High-throughput

0.691

High

1083353

CUL3
Cullin-3

1

18

High-throughput

0.691

High

1083410

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

7

High-throughput

0.691

High

1083462

CILK1
Serine/threonine-protein kinase ICK

1

1

High-throughput

0.691

High

371877

MYC
Myc proto-oncogene protein

4

5

Small-scale

0.676

High

1083413

SYMPK
Symplekin

3

2

High-throughput

0.656

High

1083364

TAF5
Transcription initiation factor TFIID subunit 5

1

12

Small-scale

0.647

High

1083442

ANLN
Anillin

3

2

High-throughput

0.640

High

1083449

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

3

8

Small-scale

0.640

High

269448

KI21B
Kinesin-like protein KIF21B

1

1

High-throughput

0.618

High

908975

NEK4
Serine/threonine-protein kinase Nek4

1

7

High-throughput

0.618

High

209255

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

12

High-throughput

0.618

High

285237

EED
Polycomb protein EED

1

17

High-throughput

0.618

High

349054

LATS1
Serine/threonine-protein kinase LATS1

1

4

High-throughput

0.618

High

400725

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.618

High

472683

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

7

High-throughput

0.618

High

675478

TYY1
Transcriptional repressor protein YY1

1

5

High-throughput

0.618

High

750411

CSTF2
Cleavage stimulation factor subunit 2

1

5

Small-scale

0.618

High

889091

RBM25
RNA-binding protein 25

1

3

High-throughput

0.618

High

897769

CDK9
Cyclin-dependent kinase 9

1

4

High-throughput

0.618

High

909544

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

2

Small-scale

0.618

High

988096

TRA2B
Transformer-2 protein homolog beta

1

4

High-throughput

0.618

High

1083347

TADBP
TAR DNA-binding protein 43

1

4

High-throughput

0.618

High

1083348

IKZF1
DNA-binding protein Ikaros

1

5

High-throughput

0.618

High

1083351

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

9

High-throughput

0.618

High

1083354

CUL4A
Cullin-4A

1

18

Small-scale

0.618

High

1083377

ZN362
Zinc finger protein 362

1

4

High-throughput

0.618

High

1083402

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

2

High-throughput

0.618

High

1083407

SP7
Transcription factor Sp7

1

4

High-throughput

0.618

High

1083409

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

2

High-throughput

0.618

High

1083414

RBP56
TATA-binding protein-associated factor 2N

1

7

Small-scale

0.618

High

1083424

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

3

High-throughput

0.618

High

1083445

SALL1
Sal-like protein 1

1

3

High-throughput

0.618

High

1083446

NLE1
Notchless protein homolog 1

1

9

High-throughput

0.618

High

1083457

IKZF3
Zinc finger protein Aiolos

1

6

High-throughput

0.618

High

1083458

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.618

High

1083463

ZN148
Zinc finger protein 148

1

3

High-throughput

0.618

High

1083447

WWOX
WW domain-containing oxidoreductase

2

1

High-throughput

0.608

High

667282

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

3

Small-scale

0.602

High

1083367

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.586

High

899744

PAPOA
Poly(A) polymerase alpha

2

4

Small-scale

0.585

High

588554

RFA2
Replication protein A 32 kDa subunit

2

2

High-throughput

0.584

High

695309

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

2

High-throughput

0.584

High

768050

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

1083371

HIF1A
Hypoxia-inducible factor 1-alpha

2

7

Small-scale

0.584

High

1083395

RBBP6
E3 ubiquitin-protein ligase RBBP6

2

3

Small-scale

0.584

High

1081357

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1083360

RHG19
Rho GTPase-activating protein 19

2

7

High-throughput

0.571

High

1083387

RHGBA
Rho GTPase-activating protein 11A

2

5

High-throughput

0.571

High

157292

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.553

High

1083359

CUL7
Cullin-7

1

2

High-throughput

0.553

High

1048839

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

251575

CCNT1
Cyclin-T1

1

4

High-throughput

0.536

High

446951

NPM
Nucleophosmin

1

2

Small-scale

0.536

High

480112

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

541974

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

574236

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.536

High

1065156

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.536

High

1083352

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.536

High

1083393

CSN6
COP9 signalosome complex subunit 6

1

1

High-throughput

0.536

High

1083441

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

2

High-throughput

0.536

High

1083450

HDAC6
Protein deacetylase HDAC6

1

11

High-throughput

0.536

High

345720

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

4

High-throughput

0.533

High

1083397

ZCH18
Zinc finger CCCH domain-containing protein 18

2

6

High-throughput

0.533

High

1083374

RHG29
Rho GTPase-activating protein 29

2

5

High-throughput

0.521

High

1083368

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.515

High

1083384

CDC73
Parafibromin

1

0

Small-scale

0.513

High

1083400

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

875639

PRC2A
Protein PRRC2A

1

3

Small-scale

0.508

High

507884

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

861586

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

5

High-throughput

0.501

High

1083369

TAF12
Transcription initiation factor TFIID subunit 12

1

1

Small-scale

0.501

High

1083432

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

2

High-throughput

0.500

High

1005737

RPP38
Ribonuclease P protein subunit p38

1

0

High-throughput

0.493

High

1083406

ARRD2
Arrestin domain-containing protein 2

1

2

High-throughput

0.489

High

1083418

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.489

High

1083431

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

2

High-throughput

0.489

High

1083365

TAF7
Transcription initiation factor TFIID subunit 7

1

0

Small-scale

0.480

High

129016

MEN1
Menin

1

1

High-throughput

0.479

High

131993

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

218115

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

241517

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

247860

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

256845

H2B1K
Histone H2B type 1-K

1

5

High-throughput

0.479

High

259859

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.479

High

278322

NCOR1
Nuclear receptor corepressor 1

1

4

High-throughput

0.479

High

280595

PR40A
Pre-mRNA-processing factor 40 homolog A

1

12

High-throughput

0.479

High

286452

WBP4
WW domain-binding protein 4

1

7

High-throughput

0.479

High

319713

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

321838

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

2

High-throughput

0.479

High

325809

UBR5
E3 ubiquitin-protein ligase UBR5

1

8

High-throughput

0.479

High

330909

KI20A
Kinesin-like protein KIF20A

1

11

High-throughput

0.479

High

406111

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.479

High

519494

MYBB
Myb-related protein B

1

3

High-throughput

0.479

High

519987

ANDR
Androgen receptor

1

5

High-throughput

0.479

High

537054

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

814798

CUX1
Homeobox protein cut-like 1

1

1

High-throughput

0.479

High

830631

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

904647

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.479

High

958626

CSN2
COP9 signalosome complex subunit 2

1

4

Small-scale

0.479

High

970408

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

979560

H4
Histone H4

1

4

High-throughput

0.479

High

980725

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.479

High

1024531

VIGLN
Vigilin

1

4

High-throughput

0.479

High

1026341

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

1035570

KIF23
Kinesin-like protein KIF23

1

8

High-throughput

0.479

High

1067230

EP300
Histone acetyltransferase p300

1

10

High-throughput

0.479

High

1083346

CSN1
COP9 signalosome complex subunit 1

1

4

Small-scale

0.479

High

1083349

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.479

High

1083350

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1083355

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

5

High-throughput

0.479

High

1083356

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

8

High-throughput

0.479

High

1083361

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

1083362

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1083366

NCOA2
Nuclear receptor coactivator 2

1

7

High-throughput

0.479

High

1083379

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

4

High-throughput

0.479

High

1083381

TSH3
Teashirt homolog 3

1

2

High-throughput

0.479

High

1083383

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1083388

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

2

High-throughput

0.479

High

1083392

HAKAI
E3 ubiquitin-protein ligase Hakai

1

1

High-throughput

0.479

High

1083394

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1083396

SLN11
Schlafen family member 11

1

2

Small-scale

0.479

High

1083398

DDX42
ATP-dependent RNA helicase DDX42

1

2

High-throughput

0.479

High

1083399

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

1

Small-scale

0.479

High

1083401

SRRM1
Serine/arginine repetitive matrix protein 1

1

3

High-throughput

0.479

High

1083403

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1083404

ARI1B
AT-rich interactive domain-containing protein 1B

1

2

High-throughput

0.479

High

1083408

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1083411

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

1083412

KAT6A
Histone acetyltransferase KAT6A

1

2

High-throughput

0.479

High

1083415

CSN5
COP9 signalosome complex subunit 5

1

3

Small-scale

0.479

High

1083417

FUBP1
Far upstream element-binding protein 1

1

4

High-throughput

0.479

High

1083420

ZBT10
Zinc finger and BTB domain-containing protein 10

1

4

High-throughput

0.479

High

1083422

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1083426

WRIP1
ATPase WRNIP1

1

1

High-throughput

0.479

High

1083427

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1083428

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

1

Small-scale

0.479

High

1083430

FACD2
Fanconi anemia group D2 protein

1

5

High-throughput

0.479

High

1083435

NSRP1
Nuclear speckle splicing regulatory protein 1

1

1

High-throughput

0.479

High

1083437

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

9

High-throughput

0.479

High

1083443

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

1083451

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1083452

TCF20
Transcription factor 20

1

1

High-throughput

0.479

High

1083456

GPTC8
G patch domain-containing protein 8

1

1

High-throughput

0.479

High

1083459

YETS2
YEATS domain-containing protein 2

1

3

High-throughput

0.479

High

1083460

FZR1
Fizzy-related protein homolog

1

13

High-throughput

0.479

High

1083461

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.479

High

1083464

NUDC
Nuclear migration protein nudC

1

4

High-throughput

0.479

High

1083419

DDT4L
DNA damage-inducible transcript 4-like protein

1

1

High-throughput

0.470

High

215087

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

0

High-throughput

0.458

High

424396

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.458

High

445538

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.458

High

628766

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

883227

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

1004329

NOP14
Nucleolar protein 14

1

0

High-throughput

0.458

High

1083344

ILF2
Interleukin enhancer-binding factor 2

1

0

Small-scale

0.458

High

1083378

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.458

High

1083386

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.458

High

1083405

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1083416

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1083444

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1083453

DACH1
Dachshund homolog 1

1

0

High-throughput

0.458

High

765447

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.445

High

1083358

CASP8
Caspase-8

1

2

High-throughput

0.445

High

1083363

PCBP2
Poly(rC)-binding protein 2

1

4

Small-scale

0.445

High

1083375

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.445

High

1083440

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

1083454

DDX41
Probable ATP-dependent RNA helicase DDX41

1

3

High-throughput

0.445

High

272117

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.437

High

276120

NIPS2
Protein NipSnap homolog 2

1

1

Small-scale

0.437

High

293627

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

411819

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

995556

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.437

High

1083372

QSER1
Glutamine and serine-rich protein 1

1

4

High-throughput

0.437

High

1083380

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

1083391

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1083429

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.437

High

1083438

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1083425

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

327971

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

5

High-throughput

0.407

High

1083390

NBEL2
Neurobeachin-like protein 2

1

11

High-throughput

0.407

High

1083421

C170L
Cep170-like protein

1

1

High-throughput

0.407

High

1083465

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

4

High-throughput

0.407

High

571421

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.249

Low

903890

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.249

Low

1083357

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.249

Low

1083373

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1083376

FA76B
Protein FAM76B

1

0

High-throughput

0.249

Low

1083385

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low

1083436

ATG5
Autophagy protein 5

1

0

High-throughput

0.249

Low

1083448

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.249

Low

1083382

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025