HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	0.60	0.408

Property	Details
Experiments	24107629
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 922
+	Hs
		325853 LATS1_HUMAN (1-1130): 0: 934: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		125071 LATS1_HUMAN (1-1130): 0: 934: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		325655 LATS1_HUMAN (1-1130): 0: 934: 100.00		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		808286 LATS2_HUMAN (13-1121): 0: 751: 49.61		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		568765 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		1299664 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		681988 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		808324 AKT3_HUMAN (603-1081): 5.7e-143: 440: 24.54		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		681731 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		325898 LATS1_HUMAN (1-1130): 0: 934: 100.00		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		325894 LATS1_HUMAN (1-1130): 0: 934: 100.00		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Hs
		1336122 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		1069657 STK38_HUMAN (622-1089): 5.96e-165: 497: 40.17		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Dm
		1360297 WARTS_DROME (161-1065): 1.96e-152: 486: 39.48		SMUF1_DROME (16-538): 1.82e-25: 115: 13.02
+	Hs
		1035209 ROCK1_HUMAN (694-1046): 9.23e-66: 245: 39.94		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82