HitPredict

Interactor 1: DLGP3 (O95886)
Disks large-associated protein 3 (DAP-3) (PSD-95/SAP90-binding protein 3) (SAP90/PSD-95-associated protein 3) (SAPAP3)
Gene: DLGAP3

Interactor 2: SHAN2 (Q9UPX8)
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)
Gene: SHANK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	10527873
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	GKAP~PDZ_6
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 979 Hs			1 1849
+	Hs
		1349917 DLGP2_HUMAN (1-979): 0: 1097: 45.66		SHAN2_HUMAN (1-1849): 0: 672: 100.00
+	Hs
		145956 DLGP1_HUMAN (1-979): 0: 1091: 38.63		SHAN2_HUMAN (1-1849): 0: 672: 100.00
+	Hs
		327247 DLGP3_HUMAN (1-979): 0: 1306: 100.00		SHAN3_HUMAN (50-1846): 1.84e-117: 413: 39.60
+	Mm
		1115961 DLGP3_MOUSE (1-979): 0: 1267: 94.49		SHAN3_MOUSE (50-1846): 5.37e-115: 406: 39.87
+	Rn
		102520 G3V7T8_RAT (1-979): 0: 1254: 94.59		SHAN3_RAT (50-1846): 7.69e-117: 411: 39.30
+	Hs
		1357785 DLGP4_HUMAN (1-979): 0: 897: 35.27		SHAN2_HUMAN (1-1849): 0: 672: 100.00
+	Hs
		1316300 DLGP2_HUMAN (1-979): 0: 1097: 45.66		SHAN3_HUMAN (50-1846): 1.84e-117: 413: 39.60
+	Mm
		1116003 DLGP2_MOUSE (1-979): 0: 1100: 45.35		SHAN3_MOUSE (50-1846): 5.37e-115: 406: 39.87
+	Hs
		145954 DLGP1_HUMAN (1-979): 0: 1091: 38.63		SHAN3_HUMAN (50-1846): 1.84e-117: 413: 39.60
+	Mm
		1116115 DLGP1_MOUSE (1-979): 0: 1061: 37.35		SHAN3_MOUSE (50-1846): 5.37e-115: 406: 39.87
+	Rn
		956996 DLGP1_RAT (1-979): 0: 1056: 37.35		SHAN3_RAT (50-1846): 7.69e-117: 411: 39.30
+	Mm
		1194593 DLGP1_MOUSE (1-979): 0: 1061: 37.35		SHAN2_MOUSE (380-1849): 5.22e-98: 351: 87.20
+	Rn
		956997 DLGP1_RAT (1-979): 0: 1056: 37.35		SHAN2_RAT (380-1849): 7.52e-99: 353: 88.41
+	Mm
		69915 DLGP4_MOUSE (1-979): 0: 911: 35.46		SHAN3_MOUSE (50-1846): 5.37e-115: 406: 39.87
+	Hs
		1316315 DLGP4_HUMAN (1-979): 0: 897: 35.27		SHAN3_HUMAN (50-1846): 1.84e-117: 413: 39.60
+	Rn
		957003 DLGP2_RAT (1-979): 0: 1104: 45.64		SHAN1_RAT (444-1849): 8.98e-28: 125: 13.34
+	Hs
		145958 DLGP1_HUMAN (1-979): 0: 1091: 38.63		SHAN1_HUMAN (521-1849): 1.53e-26: 121: 13.57
+	Mm
		88376 DLGP1_MOUSE (1-979): 0: 1061: 37.35		SHAN1_MOUSE (444-1849): 2.31e-28: 127: 13.34
+	Rn
		956998 DLGP1_RAT (1-979): 0: 1056: 37.35		SHAN1_RAT (444-1849): 8.98e-28: 125: 13.34
+	Mm
		1160650 DLGP1_MOUSE (1-979): 0: 1061: 37.35		CSKI1_MOUSE (108-294): 7.37e-14: 79.8: 16.75