Protein: STX2
Syntaxin-2 (Epimorphin)

Gene: STX2
Organism: Homo sapiens
Interactions: 79
UniProt ID: P32856

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0005198 - structural molecule activity
GO:0005484 - SNAP receptor activity
GO:0005615 - extracellular space
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

746190

VAMP2
Vesicle-associated membrane protein 2

4

20

Small-scale

0.885

High

746200

VAMP3
Vesicle-associated membrane protein 3

4

20

Small-scale

0.881

High

746189

STXB1
Syntaxin-binding protein 1

3

20

Small-scale

0.847

High

160870

STX16
Syntaxin-16

2

16

High-throughput

0.783

High

189433

STX7
Syntaxin-7

2

18

High-throughput

0.783

High

225942

STX6
Syntaxin-6

2

20

High-throughput

0.783

High

280135

SC22B
Vesicle-trafficking protein SEC22b

2

20

High-throughput

0.783

High

328635

VAMP5
Vesicle-associated membrane protein 5

2

20

High-throughput

0.783

High

746181

STX2
Syntaxin-2

2

18

High-throughput

0.783

High

746188

STX1B
Syntaxin-1B

2

19

High-throughput

0.783

High

746195

STX4
Syntaxin-4

2

18

High-throughput

0.783

High

746197

STX5
Syntaxin-5

2

18

High-throughput

0.783

High

746198

STX3
Syntaxin-3

2

18

High-throughput

0.783

High

746201

STX1A
Syntaxin-1A

2

19

High-throughput

0.783

High

746213

STX12
Syntaxin-12

2

18

High-throughput

0.783

High

746223

SNAB
Beta-soluble NSF attachment protein

2

20

High-throughput

0.783

High

746226

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

20

High-throughput

0.783

High

746228

STX8
Syntaxin-8

2

20

High-throughput

0.783

High

746221

VAMP8
Vesicle-associated membrane protein 8

2

20

Small-scale

0.754

High

123997

SNP23
Synaptosomal-associated protein 23

6

20

Small-scale

0.730

High

746199

STXB2
Syntaxin-binding protein 2

1

20

High-throughput

0.691

High

639106

SYT1
Synaptotagmin-1

1

8

Small-scale

0.647

High

125717

STXB3
Syntaxin-binding protein 3

1

20

Small-scale

0.618

High

746214

SYTL4
Synaptotagmin-like protein 4

1

11

Small-scale

0.618

High

179824

BET1
BET1 homolog

2

20

High-throughput

0.606

High

277049

ENTP3
Ectonucleoside triphosphate diphosphohydrolase 3

2

1

High-throughput

0.606

High

343322

SNP29
Synaptosomal-associated protein 29

2

20

High-throughput

0.606

High

387704

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

2

1

High-throughput

0.606

High

618372

TSN8
Tetraspanin-8

2

12

High-throughput

0.606

High

622033

CD53
Leukocyte surface antigen CD53

2

11

High-throughput

0.606

High

719054

MIP
Lens fiber major intrinsic protein

2

18

High-throughput

0.606

High

746204

RTP2
Receptor-transporting protein 2

2

1

High-throughput

0.606

High

746206

PLPP4
Phospholipid phosphatase 4

2

5

High-throughput

0.606

High

746216

SC22A
Vesicle-trafficking protein SEC22a

2

20

High-throughput

0.606

High

746222

TACAN
Transmembrane protein 120A

2

2

High-throughput

0.606

High

746224

NINJ2
Ninjurin-2

2

1

High-throughput

0.606

High

746225

ABI3
ABI gene family member 3

2

9

High-throughput

0.606

High

746229

STB5L
Syntaxin-binding protein 5-like

2

16

High-throughput

0.606

High

746231

CERT
Ceramide transfer protein

2

7

High-throughput

0.606

High

49632

T120B
Transmembrane protein 120B

2

2

High-throughput

0.553

High

69763

ZN785
Zinc finger protein 785

2

6

High-throughput

0.553

High

139819

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

2

2

High-throughput

0.553

High

327177

ZFPL1
Zinc finger protein-like 1

2

3

High-throughput

0.553

High

688375

PPLA
Phospholamban

2

1

High-throughput

0.553

High

746182

PCGF2
Polycomb group RING finger protein 2

2

1

High-throughput

0.553

High

746186

VMAT1
Chromaffin granule amine transporter

2

3

High-throughput

0.553

High

746192

RNF4
E3 ubiquitin-protein ligase RNF4

2

7

High-throughput

0.553

High

746202

AARD
Alanine- and arginine-rich domain-containing protein

2

1

High-throughput

0.553

High

746212

ANR46
Ankyrin repeat domain-containing protein 46

2

19

High-throughput

0.553

High

746215

GIMA5
GTPase IMAP family member 5

2

3

High-throughput

0.553

High

746217

RMD3
Regulator of microtubule dynamics protein 3

2

2

High-throughput

0.553

High

746219

APOL2
Apolipoprotein L2

2

2

High-throughput

0.553

High

746220

MTG1
Mitochondrial ribosome-associated GTPase 1

2

2

High-throughput

0.553

High

746227

CDC23
Cell division cycle protein 23 homolog

2

1

High-throughput

0.553

High

746232

SERP1
Stress-associated endoplasmic reticulum protein 1

2

3

High-throughput

0.553

High

746184

NSF
Vesicle-fusing ATPase

1

17

High-throughput

0.536

High

332886

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

20

Small-scale

0.501

High

746187

SNP25
Synaptosomal-associated protein 25

1

20

Small-scale

0.501

High

746210

CERS6
Ceramide synthase 6

1

1

High-throughput

0.489

High

528664

PPGB
Lysosomal protective protein

1

1

High-throughput

0.481

High

746183

SYUA
Alpha-synuclein

1

4

High-throughput

0.481

High

385494

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

Small-scale

0.479

High

746185

CDK7
Cyclin-dependent kinase 7

1

2

High-throughput

0.479

High

746194

CLH1
Clathrin heavy chain 1

1

1

Small-scale

0.479

High

746196

TP4A2
Protein tyrosine phosphatase type IVA 2

1

5

Small-scale

0.479

High

746205

STXB5
Syntaxin-binding protein 5

1

16

Small-scale

0.479

High

746203

Q59EV6
Carboxypeptidase

1

1

High-throughput

0.470

High

746211

Q7KZS0
SUMO-conjugating enzyme UBC9

1

6

High-throughput

0.470

High

641918

CD9
CD9 antigen

1

11

High-throughput

0.445

High

746193

S35A1
CMP-sialic acid transporter

1

2

High-throughput

0.445

High

746191

UBC9
SUMO-conjugating enzyme UBC9

1

6

High-throughput

0.439

High

746207

A16L1
Autophagy-related protein 16-1

1

1

Small-scale

0.437

High

129853

GET1
Guided entry of tail-anchored proteins factor 1

2

0

High-throughput

0.316

High

746208

ZCH12
Zinc finger CCHC domain-containing protein 12

2

0

High-throughput

0.316

High

746209

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

2

0

High-throughput

0.316

High

746218

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.316

High

746230

RM11
Large ribosomal subunit protein uL11m

2

0

High-throughput

0.316

High

516253

DWORF
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025