HitPredict

Interactor 1: MBD3 (O95983)
Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3)
Gene: MBD3

Interactor 2: MB3L1 (Q8WWY6)
Methyl-CpG-binding domain protein 3-like 1 (MBD3-like protein 1)
Gene: MBD3L1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	15456747
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0006346 - DNA methylation-dependent heterochromatin formation GO:0008327 - methyl-CpG binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 291 Hs			1 194
+	Hs
		328467 MBD3_HUMAN (1-291): 3.13e-166: 464: 100.00		MBD3_HUMAN (1-193): 3.4e-102: 297: 44.56
+	Hs
		328669 MBD3_HUMAN (1-291): 3.13e-166: 464: 100.00		MBD2_HUMAN (1-182): 5.61e-85: 258: 41.76
+	Hs
		1263090 MBD2_HUMAN (4-253): 1.42e-138: 398: 76.00		MB3L1_HUMAN (1-194): 1.26e-98: 285: 100.00
+	Hs
		1353856 MBD2_HUMAN (4-253): 1.42e-138: 398: 76.00		MBD2_HUMAN (1-182): 5.61e-85: 258: 41.76
+	Mm
		1378289 MBD2_MOUSE (4-253): 1.02e-138: 399: 76.00		MBD2_MOUSE (1-182): 1.15e-84: 257: 41.76
+	Hs
		328609 MBD3_HUMAN (1-291): 3.13e-166: 464: 100.00		MB3L2_HUMAN (26-187): 5.81e-61: 190: 45.73
+	Hs
		1246267 MBD2_HUMAN (4-253): 1.42e-138: 398: 76.00		MB3L2_HUMAN (26-187): 5.81e-61: 190: 45.73
+	Hs
		1263067 MB3L1_HUMAN (74-264): 9.22e-88: 261: 44.56		MB3L1_HUMAN (1-194): 1.26e-98: 285: 100.00
+	Dm
		1367140 Q9VHB7_DROME (92-243): 4.16e-60: 196: 41.40		Q9VHB7_DROME (19-172): 3.67e-59: 190: 28.66