HitPredict

Interactor 1: APCL (O95996)
Adenomatous polyposis coli protein 2 (Adenomatous polyposis coli protein-like) (APC-like)
Gene: APC2

Interactor 2: ASPP2 (Q13625)
Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)
Gene: TP53BP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	10646860
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2303 Hs			1 1128
+	Hs
		626228 APC_HUMAN (4-2294): 0: 917: 25.88		ASPP1_HUMAN (1-1128): 4.45e-135: 439: 45.38
+	Hs
		518819 APC_HUMAN (4-2294): 0: 917: 25.88		TPR_HUMAN (62-894): 9.75e-55: 211: 13.79
+	Hs
		310036 APC_HUMAN (4-2294): 0: 917: 25.88		TNKS1_HUMAN (808-1080): 1.68e-44: 178: 12.84
+	Hs
		166884 APC_HUMAN (4-2294): 0: 917: 25.88		ANR28_HUMAN (771-1049): 2.48e-23: 109: 13.78
+	Hs
		1305982 SRRM2_HUMAN (1129-2277): 1.75e-18: 95.4: 10.74		BARD1_HUMAN (676-1036): 1.54e-45: 179: 16.83
+	Hs
		1056954 MDC1_HUMAN (972-1700): 4.01e-11: 71: 11.25		BARD1_HUMAN (676-1036): 1.54e-45: 179: 16.83
+	Hs
		310053 MDC1_HUMAN (972-1700): 4.01e-11: 71: 11.25		TNKS1_HUMAN (808-1080): 1.68e-44: 178: 12.84
+	Hs
		1056981 MDC1_HUMAN (972-1700): 4.01e-11: 71: 11.25		TNKS2_HUMAN (893-1127): 6.78e-43: 172: 14.54
+	Hs
		965154 ANK2_HUMAN (675-2301): 1.1e-17: 93.1: 7.64		Q9H4D1_HUMAN (573-1024): 4.3e-26: 117: 11.58
+	Hs
		883487 ANK2_HUMAN (675-2301): 1.1e-17: 93.1: 7.64		RIPK4_HUMAN (863-1024): 1.42e-25: 116: 19.63
+	Hs
		166913 ANK2_HUMAN (675-2301): 1.1e-17: 93.1: 7.64		ANR28_HUMAN (771-1049): 2.48e-23: 109: 13.78
+	Hs
		161453 TARA_HUMAN (1085-2302): 1.16e-22: 109: 10.18		MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89
+	Hs
		862028 ANK2_HUMAN (675-2301): 1.1e-17: 93.1: 7.64		DAPK1_HUMAN (791-1011): 1.31e-20: 100: 13.12
+	Hs
		1295178 ZN469_HUMAN (1235-1954): 2.63e-11: 71.9: 11.33		Q9H4D1_HUMAN (573-1024): 4.3e-26: 117: 11.58
+	Hs
		883603 ZN469_HUMAN (1235-1954): 2.63e-11: 71.9: 11.33		RIPK4_HUMAN (863-1024): 1.42e-25: 116: 19.63
+	Mm
		103609 MICA3_MOUSE (830-1574): 3.62e-11: 71.3: 14.32		ANK3_MOUSE (681-1011): 3.26e-23: 109: 12.69
+	Dm
		113976 M9PB30_DROME (670-1377): 4.23e-20: 101: 8.71		M9PB30_DROME (335-930): 6.34e-12: 72.8: 9.61
+	Hs
		225134 ANK2_HUMAN (675-2301): 1.1e-17: 93.1: 7.64		MYPT2_HUMAN (947-1035): 1.24e-11: 71.4: 33.71
+	Hs
		1296398 CIC_HUMAN (804-1845): 2.75e-10: 68.4: 8.80		EHMT2_HUMAN (687-995): 4.44e-17: 89.1: 10.35
+	Mm
		1351630 PCLO_MOUSE (699-2083): 2.02e-13: 78.7: 8.80		PCLO_MOUSE (308-885): 1.85e-11: 71.2: 13.00