HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 591 Hs			1 189
+	Hs
		330802 PAK4_HUMAN (1-591): 0: 586: 100.00		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		331013 PAK4_HUMAN (1-591): 0: 586: 100.00		RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71
+	Hs
		330934 PAK4_HUMAN (1-591): 0: 586: 100.00		RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52
+	Hs
		349667 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		349916 AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		682177 AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94		RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71
+	Hs
		894729 STK4_HUMAN (298-588): 1.44e-122: 372: 35.50		RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02
+	Hs
		682159 AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94		RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52
+	Hs
		349992 KS6A3_HUMAN (265-591): 5.2e-113: 355: 24.27		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		350188 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		348674 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00
+	Hs
		349336 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		350320 M4K3_HUMAN (316-574): 1.61e-52: 195: 40.00		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		894759 M4K3_HUMAN (316-574): 1.61e-52: 195: 40.00		RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02
+	Hs
		348766 M4K3_HUMAN (316-574): 1.61e-52: 195: 40.00		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00
+	Hs
		350133 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		897884 PAK2_HUMAN (8-161): 8.45e-26: 113: 16.67		RAP1B_HUMAN (1-165): 1.02e-61: 191: 56.89
+	Hs
		1026199 PAK1_HUMAN (3-210): 7.55e-29: 122: 19.62		RIT1_HUMAN (3-165): 2.73e-56: 178: 52.44