HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.749

Property	Details
Experiments	32707033, 33961781, 35271311, 36931259, 24255178, 29100370, 17353931, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 591 Hs			1 246
+	Hs
		330944 PAK4_HUMAN (1-591): 0: 586: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		330968 PAK4_HUMAN (1-591): 0: 586: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		330862 PAK4_HUMAN (1-591): 0: 586: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		330938 PAK4_HUMAN (1-591): 0: 586: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		330987 PAK4_HUMAN (1-591): 0: 586: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		910063 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		683743 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		927566 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		330873 PAK4_HUMAN (1-591): 0: 586: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		647307 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		909811 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Mm
		910275 DCLK2_MOUSE (31-591): 2.24e-132: 406: 17.13		1433E_MOUSE (3-243): 4.39e-144: 405: 65.43
+	Hs
		683540 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		905151 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		982533 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		684345 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		647105 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		904852 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		982272 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		684207 DCLK2_HUMAN (31-591): 2.1e-132: 406: 17.65		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62