HitPredict

Interactor 1: DNAL4 (O96015)
Dynein axonemal light chain 4
Gene: DNAL4

Interactor 2: DYL2 (Q96FJ2)
Dynein light chain 2, cytoplasmic (8 kDa dynein light chain b) (DLC8b) (Dynein light chain LC8-type 2)
Gene: DYNLL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.911

Property	Details
Experiments	33961781, 25416956, 16189514, 31515488
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid, two hybrid pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Dynein_light~Dynein_light
Common GO terms	GO:0005874 - microtubule GO:0005886 - plasma membrane GO:0005929 - cilium
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 105 Hs			1 89
+	Hs
		331156 DNAL4_HUMAN (1-105): 6.33e-45: 142: 100.00		DYL1_HUMAN (1-89): 1.8e-47: 147: 93.26
+	Dm
		1096023 DYL1_DROME (21-104): 8.43e-39: 126: 33.33		DYL1_DROME (1-89): 7.55e-48: 148: 96.63
+	Hs
		928254 DYL1_HUMAN (21-104): 1.27e-38: 125: 35.71		DYL1_HUMAN (1-89): 1.8e-47: 147: 93.26
+	Ce
		1095042 DYL1_CAEEL (21-104): 2.34e-38: 125: 32.14		DYL1_CAEEL (1-89): 5.57e-47: 146: 95.51
+	Hs
		928427 DYL1_HUMAN (21-104): 1.27e-38: 125: 35.71		DYL2_HUMAN (1-89): 7.09e-47: 146: 100.00
+	Hs
		1291271 DYL2_HUMAN (21-104): 7.39e-38: 123: 33.33		DYL2_HUMAN (1-89): 7.09e-47: 146: 100.00
+	Hs
		331150 DNAL4_HUMAN (1-105): 6.33e-45: 142: 100.00		DNAL4_HUMAN (7-89): 8.16e-30: 103: 32.94
+	At
		1196448 Q84VW0_ARATH (19-104): 9.84e-36: 119: 33.72		Q9M810_ARATH (1-89): 6e-37: 121: 41.76
+	At
		1340184 Q9LW74_ARATH (21-105): 6.21e-34: 114: 29.07		Q9M810_ARATH (1-89): 6e-37: 121: 41.76
+	Sc
		971981 DYL1_YEAST (17-105): 7.59e-34: 113: 30.34		DYL1_YEAST (1-89): 3.61e-37: 121: 46.74