HitPredict

Interactor 1: CHK2 (O96017)
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)
Gene: CHEK2

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20159774
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006974 - DNA damage response GO:0019901 - protein kinase binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 758
+	Hs
		496408 AKT2_HUMAN (62-535): 1.04e-140: 417: 23.08		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496407 AKT1_HUMAN (62-535): 8.03e-139: 412: 21.58		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496245 KPCA_HUMAN (44-542): 6.5e-132: 400: 21.11		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		408538 KPCB_HUMAN (44-535): 2.7e-131: 399: 20.80		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496248 KAPCA_HUMAN (178-536): 3.21e-129: 382: 29.32		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496307 KAPCB_HUMAN (178-537): 6.63e-129: 382: 28.96		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		92372 E9PBG7_HUMAN (215-486): 7.69e-123: 372: 37.59		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496977 KCC2D_HUMAN (215-486): 5.35e-122: 369: 37.96		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		581978 KPCB_RAT (44-535): 1.26e-130: 397: 20.60		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94201 KPCB_RAT (44-535): 1.26e-130: 397: 20.60		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Rn
		581976 KAPCB_RAT (178-536): 1.67e-128: 380: 28.49		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94199 KAPCB_RAT (178-536): 1.67e-128: 380: 28.49		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Hs
		331286 CHK2_HUMAN (1-543): 1.66e-175: 508: 100.00		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Hs
		152597 AKT1_HUMAN (62-535): 8.03e-139: 412: 21.58		KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55
+	Hs
		503261 KAPCA_HUMAN (178-536): 3.21e-129: 382: 29.32		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Hs
		503264 KAPCB_HUMAN (178-537): 6.63e-129: 382: 28.96		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Mm
		592770 KCC2D_MOUSE (215-486): 5.35e-122: 369: 37.96		MTAP2_MOUSE (26-758): 1.71e-30: 131: 23.89
+	Bt
		337290 KAPCA_BOVIN (178-537): 9.07e-129: 381: 29.51		TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00