Interactor 1: CHK2 (O96017)
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)
Gene: CHEK2

Interactor 2: ATR (Q13535)
Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)
Gene: ATR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 0.60 0.602

The method score is based on:

Property Details
Experiments 17035231, 10973490
Identification Methods enzymatic study
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000077 - DNA damage checkpoint signaling
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 8 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 543
Hs

1 2644
+ Xl
+ Mm
+ Hs
+ Hs
+ Hs
+ At
+ Sp
+ Sp
+ Sc
+ Sc
+ Hs
+ Hs
+ Hs
+ Sp
+ Hs
+ Hs
+ Hs
+ Hs
+ Sc

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Last updated: 15 Jul 2024