Protein: ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)

Gene: ASH2L
Organism: Homo sapiens
Interactions: 233
UniProt ID: Q9UBL3

Gene Ontology (top 5):
GO:0000976 - transcription cis-regulatory region binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006974 - DNA damage response
GO:0008013 - beta-catenin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1041614

KMT2A
Histone-lysine N-methyltransferase 2A

18

20

Small-scale

0.987

High

161520

KMT2D
Histone-lysine N-methyltransferase 2D

17

20

Small-scale

0.986

High

175941

SET1A
Histone-lysine N-methyltransferase SETD1A

16

20

Small-scale

0.985

High

1338281

KMT2C
Histone-lysine N-methyltransferase 2C

14

20

Small-scale

0.983

High

1458472

SET1B
Histone-lysine N-methyltransferase SETD1B

11

20

Small-scale

0.979

High

1458470

KMT2B
Histone-lysine N-methyltransferase 2B

11

20

Small-scale

0.977

High

1458465

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

3

15

Small-scale

0.834

High

1439228

CHD8
Chromodomain-helicase-DNA-binding protein 8

2

20

Small-scale

0.834

High

1145552

RBBP5
Retinoblastoma-binding protein 5

30

18

Small-scale

0.769

High

965302

WDR5
WD repeat-containing protein 5

28

14

Small-scale

0.768

High

1420472

DPY30
Protein dpy-30 homolog

21

6

Small-scale

0.768

High

1454054

CXXC1
CXXC-type zinc finger protein 1

16

14

Small-scale

0.762

High

1130606

NCOA6
Nuclear receptor coactivator 6

12

10

Small-scale

0.759

High

194623

KDM6A
Lysine-specific demethylase 6A

12

7

Small-scale

0.755

High

905508

HCFC1
Host cell factor 1

9

7

Small-scale

0.753

High

1458479

HCFC2
Host cell factor 2

9

7

Small-scale

0.751

High

1257154

PAXI1
PAX-interacting protein 1

8

10

Small-scale

0.751

High

129509

MEN1
Menin

7

2

Small-scale

0.741

High

1250053

WDR82
WD repeat-containing protein 82

6

20

Small-scale

0.732

High

186095

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

6

5

Small-scale

0.724

High

1338710

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

5

8

Small-scale

0.712

High

414767

P53
Cellular tumor antigen p53

3

8

Small-scale

0.686

High

326076

UBR5
E3 ubiquitin-protein ligase UBR5

4

13

Small-scale

0.683

High

397131

ESR1
Estrogen receptor

4

20

Small-scale

0.683

High

1394244

BOD1
Biorientation of chromosomes in cell division protein 1

4

1

Small-scale

0.683

High

1413533

PAGR1
PAXIP1-associated glutamate-rich protein 1

4

0

Small-scale

0.661

High

1162066

H31T
Histone H3.1t

3

14

Small-scale

0.655

High

1316165

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

20

Small-scale

0.647

High

911143

IMA1
Importin subunit alpha-1

3

4

Small-scale

0.633

High

995324

CSK2B
Casein kinase II subunit beta

3

0

Small-scale

0.628

High

316107

RECQ4
ATP-dependent DNA helicase Q4

1

15

High-throughput

0.618

High

1155860

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.618

High

1253880

SRCAP
Helicase SRCAP

1

15

High-throughput

0.618

High

1255927

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

1454484

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

20

Small-scale

0.618

High

158704

UTY
Histone demethylase UTY

2

5

Small-scale

0.611

High

520423

ANDR
Androgen receptor

2

20

Small-scale

0.611

High

625681

CSK22
Casein kinase II subunit alpha'

2

5

Small-scale

0.611

High

1278982

EMSY
BRCA2-interacting transcriptional repressor EMSY

2

16

Small-scale

0.611

High

765081

CTNB1
Catenin beta-1

2

9

Small-scale

0.602

High

1140982

KIF14
Kinesin-like protein KIF14

2

7

High-throughput

0.601

High

1067790

EP300
Histone acetyltransferase p300

1

12

Small-scale

0.597

High

1081571

Q0VDC6
peptidylprolyl isomerase

1

10

High-throughput

0.594

High

789586

PPARG
Peroxisome proliferator-activated receptor gamma

2

20

Small-scale

0.594

High

799541

BRCA1
Breast cancer type 1 susceptibility protein

2

19

High-throughput

0.586

High

961877

RL37A
Large ribosomal subunit protein eL43

2

0

High-throughput

0.585

High

648384

USF1
Upstream stimulatory factor 1

2

14

Small-scale

0.584

High

872839

SOX2
Transcription factor SOX-2

2

16

Small-scale

0.584

High

980478

H4
Histone H4

2

7

High-throughput

0.584

High

1123160

FHL2
Four and a half LIM domains protein 2

2

6

Small-scale

0.584

High

1133709

NFIX
Nuclear factor 1 X-type

2

3

High-throughput

0.584

High

1152754

ELF2
ETS-related transcription factor Elf-2

2

13

High-throughput

0.584

High

1380227

FBXW7
F-box/WD repeat-containing protein 7

2

19

Small-scale

0.584

High

1449152

MBIP1
MAP3K12-binding inhibitory protein 1

2

3

High-throughput

0.584

High

666924

CCNC
Cyclin-C

2

0

High-throughput

0.580

High

1336765

RB15B
Putative RNA-binding protein 15B

2

2

Small-scale

0.571

High

1127217

RBM39
RNA-binding protein 39

1

8

Small-scale

0.561

High

942011

NDK5
Nucleoside diphosphate kinase homolog 5

2

3

High-throughput

0.558

High

1315608

MICU2
Calcium uptake protein 2, mitochondrial

2

1

High-throughput

0.558

High

1434448

ZN335
Zinc finger protein 335

1

2

Small-scale

0.554

High

1347476

CEP76
Centrosomal protein of 76 kDa

2

1

High-throughput

0.553

High

1146287

ANKR1
Ankyrin repeat domain-containing protein 1

1

6

High-throughput

0.541

High

1272584

CSN6
COP9 signalosome complex subunit 6

1

6

High-throughput

0.541

High

1333252

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

3

High-throughput

0.541

High

1430223

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

12

High-throughput

0.541

High

1458467

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

4

High-throughput

0.541

High

1411575

PYGO2
Pygopus homolog 2

1

0

Small-scale

0.537

High

224384

BUB3
Mitotic checkpoint protein BUB3

1

16

High-throughput

0.536

High

229092

AKAP8
A-kinase anchor protein 8

1

2

Small-scale

0.536

High

502160

H2AZ
Histone H2A.Z

1

5

High-throughput

0.536

High

601891

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.536

High

854362

KI67
Proliferation marker protein Ki-67

1

9

High-throughput

0.536

High

885914

KC1E
Casein kinase I isoform epsilon

1

3

High-throughput

0.536

High

960928

RL15
Large ribosomal subunit protein eL15

1

1

High-throughput

0.536

High

981724

RAN
GTP-binding nuclear protein Ran

1

4

High-throughput

0.536

High

1116091

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.536

High

1163258

H2B2E
Histone H2B type 2-E

1

10

High-throughput

0.536

High

1323176

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

Small-scale

0.536

High

1366140

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

15

High-throughput

0.536

High

1391826

AURKB
Aurora kinase B

1

9

High-throughput

0.536

High

1420513

FOXQ1
Forkhead box protein Q1

1

13

High-throughput

0.536

High

1431068

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.536

High

1439293

E41L5
Band 4.1-like protein 5

1

1

High-throughput

0.536

High

1458474

KDM2A
Lysine-specific demethylase 2A

1

5

High-throughput

0.536

High

1219993

SPRY7
SPRY domain-containing protein 7

1

0

Small-scale

0.517

High

931143

HSP72
Heat shock-related 70 kDa protein 2

1

4

High-throughput

0.515

High

1240714

CDC73
Parafibromin

1

0

Small-scale

0.513

High

181952

SMAD9
Mothers against decapentaplegic homolog 9

1

8

High-throughput

0.508

High

786908

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

Small-scale

0.508

High

998902

H31
Histone H3.1

1

14

Small-scale

0.501

High

1407930

ANM1
Protein arginine N-methyltransferase 1

1

12

Small-scale

0.501

High

773796

ACTN2
Alpha-actinin-2

1

1

High-throughput

0.494

High

995867

ACTC
Actin, alpha cardiac muscle 1

1

6

High-throughput

0.494

High

1027909

MYPC1
Myosin-binding protein C, slow-type

1

9

High-throughput

0.494

High

1217947

MYOM3
Myomesin-3

1

9

High-throughput

0.494

High

1361927

TITIN
Titin

1

11

High-throughput

0.494

High

572963

INSRR
Insulin receptor-related protein

1

7

High-throughput

0.489

High

1348898

ARRD2
Arrestin domain-containing protein 2

1

6

High-throughput

0.489

High

1406796

BARD1
BRCA1-associated RING domain protein 1

1

7

High-throughput

0.481

High

1458468

DNM3L
DNA

1

0

Small-scale

0.480

High

64442

BDP1
Transcription factor TFIIIB component B'' homolog

1

12

High-throughput

0.479

High

65986

CCD69
Coiled-coil domain-containing protein 69

1

1

High-throughput

0.479

High

173497

XPO1
Exportin-1

1

4

High-throughput

0.479

High

176093

KDM6B
Lysine-specific demethylase 6B

1

9

Small-scale

0.479

High

239629

MED14
Mediator of RNA polymerase II transcription subunit 14

1

10

Small-scale

0.479

High

244112

ZN292
Zinc finger protein 292

1

1

High-throughput

0.479

High

283151

PSIP1
PC4 and SFRS1-interacting protein

1

6

High-throughput

0.479

High

322681

KDM4B
Lysine-specific demethylase 4B

1

4

Small-scale

0.479

High

345218

ZMYM6
Zinc finger MYM-type protein 6

1

1

High-throughput

0.479

High

370799

FOS
Protein c-Fos

1

6

High-throughput

0.479

High

373389

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

404510

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

445280

S10A6
Protein S100-A6

1

4

High-throughput

0.479

High

478242

SNRPA
U1 small nuclear ribonucleoprotein A

1

8

Small-scale

0.479

High

487845

PARP1
Poly [ADP-ribose] polymerase 1

1

9

High-throughput

0.479

High

519431

MYB
Transcriptional activator Myb

1

5

Small-scale

0.479

High

581737

MYOD1
Myoblast determination protein 1

1

1

High-throughput

0.479

High

607183

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

662291

PAX7
Paired box protein Pax-7

1

5

Small-scale

0.479

High

675711

TYY1
Transcriptional repressor protein YY1

1

4

High-throughput

0.479

High

685372

PAX6
Paired box protein Pax-6

1

5

High-throughput

0.479

High

718644

CDC27
Cell division cycle protein 27 homolog

1

2

Small-scale

0.479

High

739041

ELF1
ETS-related transcription factor Elf-1

1

14

High-throughput

0.479

High

755015

H2B1B
Histone H2B type 1-B

1

10

High-throughput

0.479

High

788249

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.479

High

834079

HNF4A
Hepatocyte nuclear factor 4-alpha

1

18

High-throughput

0.479

High

862514

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

895810

LHX2
LIM/homeobox protein Lhx2

1

1

High-throughput

0.479

High

911418

IMA5
Importin subunit alpha-5

1

4

Small-scale

0.479

High

931715

RD23B
UV excision repair protein RAD23 homolog B

1

5

High-throughput

0.479

High

937950

FOXA1
Hepatocyte nuclear factor 3-alpha

1

13

High-throughput

0.479

High

943328

RBM11
Splicing regulator RBM11

1

14

High-throughput

0.479

High

981156

H2B1C
Histone H2B type 1-C/E/F/G/I

1

10

High-throughput

0.479

High

998084

CSK21
Casein kinase II subunit alpha

1

6

High-throughput

0.479

High

1017504

FOXK1
Forkhead box protein K1

1

11

High-throughput

0.479

High

1029165

E2F1
Transcription factor E2F1

1

3

Small-scale

0.479

High

1029776

FOXK2
Forkhead box protein K2

1

11

High-throughput

0.479

High

1029962

RUNX1
Runt-related transcription factor 1

1

3

High-throughput

0.479

High

1089044

TP53B
TP53-binding protein 1

1

6

High-throughput

0.479

High

1093441

TRI32
E3 ubiquitin-protein ligase TRIM32

1

6

Small-scale

0.479

High

1105674

GOGA4
Golgin subfamily A member 4

1

10

Small-scale

0.479

High

1112345

PWP1
Periodic tryptophan protein 1 homolog

1

16

High-throughput

0.479

High

1114535

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1129771

MDC1
Mediator of DNA damage checkpoint protein 1

1

18

High-throughput

0.479

High

1137563

SUZ12
Polycomb protein SUZ12

1

6

High-throughput

0.479

High

1153938

SMAD2
Mothers against decapentaplegic homolog 2

1

8

Small-scale

0.479

High

1154017

SMAD1
Mothers against decapentaplegic homolog 1

1

8

Small-scale

0.479

High

1156884

E2F4
Transcription factor E2F4

1

3

Small-scale

0.479

High

1240272

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

1

High-throughput

0.479

High

1276117

KANL1
KAT8 regulatory NSL complex subunit 1

1

1

High-throughput

0.479

High

1310136

MGAP
MAX gene-associated protein

1

2

High-throughput

0.479

High

1312659

MSRB3
Methionine-R-sulfoxide reductase B3

1

1

Small-scale

0.479

High

1314718

SRRM1
Serine/arginine repetitive matrix protein 1

1

9

High-throughput

0.479

High

1315067

ZZZ3
ZZ-type zinc finger-containing protein 3

1

3

High-throughput

0.479

High

1329920

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1336866

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

8

Small-scale

0.479

High

1351186

SP7
Transcription factor Sp7

1

9

High-throughput

0.479

High

1352808

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

1364647

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1365555

JADE3
Protein Jade-3

1

16

High-throughput

0.479

High

1367488

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1368403

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

1370866

FUBP2
Far upstream element-binding protein 2

1

19

High-throughput

0.479

High

1390179

MCRS1
Microspherule protein 1

1

1

High-throughput

0.479

High

1405647

ELF4
ETS-related transcription factor Elf-4

1

13

High-throughput

0.479

High

1428996

WWTR1
WW domain-containing transcription regulator protein 1

1

16

High-throughput

0.479

High

1434980

SOX17
Transcription factor SOX-17

1

15

High-throughput

0.479

High

1436237

CSR2B
Cysteine-rich protein 2-binding protein

1

10

High-throughput

0.479

High

1437163

KANL2
KAT8 regulatory NSL complex subunit 2

1

1

High-throughput

0.479

High

1446915

JADE2
E3 ubiquitin-protein ligase Jade-2

1

11

High-throughput

0.479

High

1453013

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1454736

KANL3
KAT8 regulatory NSL complex subunit 3

1

2

High-throughput

0.479

High

1454805

RERE
Arginine-glutamic acid dipeptide repeats protein

1

16

High-throughput

0.479

High

1458466

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1458469

YETS2
YEATS domain-containing protein 2

1

13

High-throughput

0.479

High

1458471

PHF8
Histone lysine demethylase PHF8

1

11

Small-scale

0.479

High

1458473

ICE1
Little elongation complex subunit 1

1

1

High-throughput

0.479

High

1458477

MSRB2
Methionine-R-sulfoxide reductase B2, mitochondrial

1

1

Small-scale

0.479

High

1458478

LOXL2
Lysyl oxidase homolog 2

1

4

Small-scale

0.479

High

282631

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

5

High-throughput

0.470

High

259158

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.458

High

370021

TIMP1
Metalloproteinase inhibitor 1

1

0

Small-scale

0.458

High

851434

PRS6B
26S proteasome regulatory subunit 6B

1

0

Small-scale

0.458

High

904404

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.458

High

1107633

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

Small-scale

0.458

High

1120104

COX17
Cytochrome c oxidase copper chaperone

1

0

Small-scale

0.458

High

1132674

MEF2D
Myocyte-specific enhancer factor 2D

1

0

Small-scale

0.458

High

1147142

ELOC
Elongin-C

1

0

Small-scale

0.458

High

1349229

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

0

High-throughput

0.458

High

1357590

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1396484

CAZA3
F-actin-capping protein subunit alpha-3

1

0

High-throughput

0.458

High

1453346

SACS
Sacsin

1

0

Small-scale

0.458

High

1458475

PDIP2
Polymerase delta-interacting protein 2

1

0

Small-scale

0.458

High

1458480

SETBP
SET-binding protein

1

0

Small-scale

0.458

High

344350

PTBP3
Polypyrimidine tract-binding protein 3

1

5

High-throughput

0.445

High

1234998

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

1257000

FBX50
F-box only protein 50

1

1

High-throughput

0.445

High

1291948

WDR5B
WD repeat-containing protein 5B

1

14

Small-scale

0.445

High

1367890

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

12

High-throughput

0.445

High

1403036

SIN3A
Paired amphipathic helix protein Sin3a

1

2

Small-scale

0.445

High

1453270

GRHL1
Grainyhead-like protein 1 homolog

1

3

High-throughput

0.445

High

643576

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

1

Small-scale

0.437

High

1147507

RHEB
GTP-binding protein Rheb

1

2

Small-scale

0.437

High

1450302

PCMD2
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

1

1

High-throughput

0.437

High

1454292

RCC2
Protein RCC2

1

2

High-throughput

0.437

High

615245

IL1RA
Interleukin-1 receptor antagonist protein

1

0

High-throughput

0.426

High

1108816

ASAH1
Acid ceramidase

1

0

High-throughput

0.426

High

1430681

CK054
Ester hydrolase C11orf54

1

0

High-throughput

0.426

High

62606

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

424562

PAI2
Plasminogen activator inhibitor 2

1

3

High-throughput

0.407

High

1309628

SPA12
Serpin A12

1

5

High-throughput

0.407

High

1358597

POF1B
Protein POF1B

1

1

High-throughput

0.407

High

1131245

MESD
LRP chaperone MESD

2

0

High-throughput

0.316

High

1105185

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.282

High

946376

CU058
Uncharacterized protein C21orf58

1

0

High-throughput

0.279

Low

1322511

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.279

Low

1384748

ANKR9
Ankyrin repeat domain-containing protein 9

1

0

High-throughput

0.279

Low

1397792

KAD7
Adenylate kinase 7

1

0

High-throughput

0.279

Low

1458476

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

0

High-throughput

0.279

Low

337621

FMNL1
Formin-like protein 1

1

0

Small-scale

0.249

Low

903820

SSRD
Translocon-associated protein subunit delta

1

0

Small-scale

0.249

Low

1139411

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

Small-scale

0.249

Low

1432075

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

Small-scale

0.249

Low

369928

CO3
Complement C3

1

0

High-throughput

0.232

Low

389893

TTHY
Transthyretin

1

0

High-throughput

0.232

Low

1159430

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.232

Low

1242371

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.232

Low

1330798

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low

1338079

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

0

High-throughput

0.232

Low

1430314

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.232

Low

1436226

Q9H8E5
cDNA FLJ13705 fis, clone PLACE2000302

1

0

High-throughput

0.232

Low

1449844

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025