HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: H15 (P16401)
Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)
Gene: H1-5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 226
+	Hs
		331717 NSD2_HUMAN (1-1365): 0: 980: 100.00		H12_HUMAN (32-174): 1.09e-17: 80.2: 75.17
+	Hs
		331706 NSD2_HUMAN (1-1365): 0: 980: 100.00		H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29
+	Hs
		331791 NSD2_HUMAN (1-1365): 0: 980: 100.00		H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29
+	Hs
		971335 NSD3_HUMAN (116-1340): 0: 758: 45.19		H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29
+	Hs
		1061756 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		SHPRH_HUMAN (14-189): 3.16e-65: 220: 27.12
+	Mm
		990819 EZH2_MOUSE (904-1188): 7.38e-59: 219: 22.48		H1T_MOUSE (1-219): 2.32e-30: 113: 49.77
+	Hs
		559417 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H13_HUMAN (1-184): 1.62e-22: 93.3: 68.48
+	Hs
		559109 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H15_HUMAN (1-118): 3.29e-18: 81.7: 100.00
+	Hs
		559730 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H12_HUMAN (32-174): 1.09e-17: 80.2: 75.17
+	Hs
		971187 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29
+	Hs
		489204 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29
+	Hs
		971310 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29
+	Hs
		559663 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		H12_HUMAN (32-174): 1.09e-17: 80.2: 75.17
+	Hs
		489011 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29
+	Hs
		559470 NSD1_HUMAN (69-658): 1.83e-25: 117: 14.33		H13_HUMAN (1-184): 1.62e-22: 93.3: 68.48
+	Hs
		559217 NSD1_HUMAN (69-658): 1.83e-25: 117: 14.33		H15_HUMAN (1-118): 3.29e-18: 81.7: 100.00
+	Hs
		559895 NSD1_HUMAN (69-658): 1.83e-25: 117: 14.33		H12_HUMAN (32-174): 1.09e-17: 80.2: 75.17
+	Hs
		489205 NSD1_HUMAN (69-658): 1.83e-25: 117: 14.33		H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29