HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 272
+	Hs
		331795 NSD2_HUMAN (1-1365): 0: 980: 100.00		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		331803 NSD2_HUMAN (1-1365): 0: 980: 100.00		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		992789 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		1028670 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00
+	Hs
		1028558 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		SRSF9_HUMAN (2-211): 1.47e-52: 172: 33.02
+	Hs
		1029077 SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		975239 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00
+	Hs
		975231 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		975240 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Sc
		376833 SET2_YEAST (972-1208): 9.39e-61: 225: 35.12		PABP_YEAST (86-192): 7.08e-15: 75.9: 19.64
+	Hs
		1031345 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		PABP4_HUMAN (104-189): 3.45e-16: 80.1: 21.98
+	Hs
		516536 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		963528 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		TIAR_HUMAN (3-103): 3.49e-12: 67.4: 14.56
+	Hs
		951979 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Mm
		952203 Q6AXH7_MOUSE (904-1188): 1.25e-58: 218: 22.48		SRSF3_MOUSE (4-78): 1.85e-11: 62.8: 47.56
+	Zm
		6220 A0A1D6EZN1_MAIZE (1046-1202): 5.56e-56: 201: 32.62		A0A1D6E6L1_MAIZE (103-192): 2.53e-15: 77.4: 25.26
+	Dm
		332738 CHDM_DROME (1238-1285): 6.78e-12: 72.7: 42.00		SRR55_DROME (1-179): 1.66e-56: 187: 58.64
+	Hs
		516645 NSD1_HUMAN (69-658): 1.83e-25: 117: 14.33		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56