Protein: MTMR5
Myotubularin-related protein 5 (Inactive phosphatidylinositol 3-phosphatase 5) (SET-binding factor 1) (Sbf1)

Gene: MTMR5, SBF1
Organism: Homo sapiens
Interactions: 156
UniProt ID: O95248

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0006470 - protein dephosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

331751

MTMR2
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2

6

16

Small-scale

0.943

High

331750

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

4

16

High-throughput

0.895

High

331773

SKAP1
Src kinase-associated phosphoprotein 1

3

8

High-throughput

0.861

High

331808

RAB6B
Ras-related protein Rab-6B

3

11

High-throughput

0.855

High

331719

TGFR2
TGF-beta receptor type-2

3

0

High-throughput

0.816

High

331772

MTMRD
Myotubularin-related protein 13

2

17

High-throughput

0.802

High

331709

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

3

0

High-throughput

0.784

High

331692

RASK
GTPase KRas

2

20

High-throughput

0.754

High

331738

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

331756

RAB35
Ras-related protein Rab-35

2

13

High-throughput

0.754

High

331816

FBW1B
F-box/WD repeat-containing protein 11

2

6

High-throughput

0.737

High

331768

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.698

High

331711

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.691

High

331777

NEK7
Serine/threonine-protein kinase Nek7

1

4

High-throughput

0.691

High

238995

ZNRD2
Protein ZNRD2

3

2

High-throughput

0.662

High

331722

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

8

High-throughput

0.662

High

193479

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

1

High-throughput

0.656

High

331782

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.656

High

331706

LYAM2
E-selectin

2

1

High-throughput

0.628

High

331718

CADH5
Cadherin-5

2

2

High-throughput

0.628

High

331755

TEBP
Prostaglandin E synthase 3

2

1

High-throughput

0.628

High

331794

LZTS2
Leucine zipper putative tumor suppressor 2

2

7

High-throughput

0.628

High

331806

LRC4C
Leucine-rich repeat-containing protein 4C

2

4

High-throughput

0.628

High

331781

SNX21
Sorting nexin-21

1

1

High-throughput

0.618

High

126414

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

331686

MTMR5
Myotubularin-related protein 5

1

16

High-throughput

0.618

High

331690

RASN
GTPase NRas

1

20

High-throughput

0.618

High

331691

RASH
GTPase HRas

1

13

High-throughput

0.618

High

331698

RHOC
Rho-related GTP-binding protein RhoC

1

17

High-throughput

0.618

High

331702

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

331704

RAC2
Ras-related C3 botulinum toxin substrate 2

1

16

High-throughput

0.618

High

331725

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

331730

RAC3
Ras-related C3 botulinum toxin substrate 3

1

18

High-throughput

0.618

High

331731

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

331732

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

331733

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

331737

ARF6
ADP-ribosylation factor 6

1

8

High-throughput

0.618

High

331739

RAC1
Ras-related C3 botulinum toxin substrate 1

1

18

High-throughput

0.618

High

331742

RHOG
Rho-related GTP-binding protein RhoG

1

16

High-throughput

0.618

High

331745

TLE1
Transducin-like enhancer protein 1

1

3

High-throughput

0.618

High

331757

KS6A2
Ribosomal protein S6 kinase alpha-2

1

2

High-throughput

0.618

High

331759

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

331771

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

331779

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

331788

SNX27
Sorting nexin-27

1

9

High-throughput

0.618

High

331796

IFT27
Intraflagellar transport protein 27 homolog

1

16

High-throughput

0.618

High

331805

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

331801

RPAP3
RNA polymerase II-associated protein 3

2

8

High-throughput

0.611

High

331802

WDR55
WD repeat-containing protein 55

2

3

High-throughput

0.611

High

331726

EFNB2
Ephrin-B2

3

5

High-throughput

0.609

High

331811

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

3

2

High-throughput

0.609

High

331763

HENMT
Small RNA 2'-O-methyltransferase

2

0

High-throughput

0.602

High

331804

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

331693

FRIL
Ferritin light chain

2

1

High-throughput

0.601

High

331701

LAMP1
Lysosome-associated membrane glycoprotein 1

2

4

High-throughput

0.584

High

331815

ZRAN1
Ubiquitin thioesterase ZRANB1

2

3

High-throughput

0.584

High

331708

KPCA
Protein kinase C alpha type

1

2

High-throughput

0.575

High

331776

HAVR2
Hepatitis A virus cellular receptor 2

2

1

High-throughput

0.574

High

331694

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

331746

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

331695

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.553

High

331707

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.553

High

331715

EPHA2
Ephrin type-A receptor 2

1

6

High-throughput

0.553

High

331800

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

331818

PNMA2
Paraneoplastic antigen Ma2

2

2

High-throughput

0.549

High

295559

CIB2
Calcium and integrin-binding family member 2

1

7

High-throughput

0.536

High

296756

ST1C4
Sulfotransferase 1C4

1

1

High-throughput

0.536

High

331688

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

3

High-throughput

0.536

High

331703

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.536

High

331713

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

331721

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

2

High-throughput

0.536

High

331735

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

331736

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.536

High

331743

EFNB1
Ephrin-B1

1

5

High-throughput

0.536

High

331753

MAP7
Ensconsin

1

4

High-throughput

0.536

High

331754

SRC8
Src substrate cortactin

1

2

High-throughput

0.536

High

331760

INF2
Inverted formin-2

1

1

High-throughput

0.536

High

331784

TRI52
E3 ubiquitin-protein ligase TRIM52

1

4

High-throughput

0.536

High

331785

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

331790

PPM1M
Protein phosphatase 1M

1

3

High-throughput

0.536

High

331814

KLH14
Kelch-like protein 14

1

1

High-throughput

0.536

High

331823

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

105011

APRIO
Alternative prion protein

2

5

High-throughput

0.533

High

331696

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

331699

TFPT
TCF3 fusion partner

1

0

High-throughput

0.513

High

331740

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.513

High

331741

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

331747

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.513

High

331748

HDHD1
Pseudouridine-5'-phosphatase

1

0

High-throughput

0.513

High

331762

INAVA
Innate immunity activator protein

1

0

High-throughput

0.513

High

331789

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

331797

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

331744

KMT2A
Histone-lysine N-methyltransferase 2A

1

3

Small-scale

0.501

High

190295

COPT1
High affinity copper uptake protein 1

1

2

High-throughput

0.489

High

331710

IBP3
Insulin-like growth factor-binding protein 3

1

1

High-throughput

0.489

High

331712

CRBB3
Beta-crystallin B3

1

1

High-throughput

0.489

High

331716

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.489

High

331727

CRBA4
Beta-crystallin A4

1

1

High-throughput

0.489

High

331766

BTNL9
Butyrophilin-like protein 9

1

4

High-throughput

0.489

High

331774

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

331819

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

2

High-throughput

0.489

High

164676

TNF11
Tumor necrosis factor ligand superfamily member 11

1

0

High-throughput

0.486

High

96804

PTG3L
Putative protein PTGES3L

1

1

High-throughput

0.479

High

331687

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

331689

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

331705

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

331717

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

331724

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

331752

CUL3
Cullin-3

1

6

High-throughput

0.479

High

331769

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

331793

DNJC7
DnaJ homolog subfamily C member 7

1

8

High-throughput

0.479

High

331799

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

331803

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

331807

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.479

High

331813

CT2NL
CTTNBP2 N-terminal-like protein

1

5

High-throughput

0.479

High

331817

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

4

High-throughput

0.479

High

331809

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

2

Small-scale

0.470

High

331720

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.458

High

331778

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

1

0

Small-scale

0.458

High

331787

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

331795

UQCC2
Ubiquinol-cytochrome c reductase complex assembly factor 2

1

0

High-throughput

0.458

High

331798

IN80B
INO80 complex subunit B

1

0

High-throughput

0.458

High

331821

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.458

High

58779

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

8

High-throughput

0.445

High

258694

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.445

High

331700

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

331729

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

331765

NIPA3
Magnesium transporter NIPA3

1

1

High-throughput

0.445

High

331812

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

1

High-throughput

0.445

High

211615

ZNHI1
Zinc finger HIT domain-containing protein 1

1

1

High-throughput

0.437

High

279254

TULP3
Tubby-related protein 3

1

1

High-throughput

0.437

High

331714

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

331728

PMS1
PMS1 protein homolog 1

1

2

High-throughput

0.437

High

331734

WDR5
WD repeat-containing protein 5

1

3

Small-scale

0.437

High

331749

SSRP1
FACT complex subunit SSRP1

1

2

High-throughput

0.437

High

331775

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.437

High

331780

ESR2
Estrogen receptor beta

1

7

High-throughput

0.437

High

62437

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.426

High

331761

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

1

High-throughput

0.407

High

331792

CCNL2
Cyclin-L2

1

1

High-throughput

0.407

High

331770

RHEX
Regulator of hemoglobinization and erythroid cell expansion protein

3

0

High-throughput

0.347

High

331697

CO1A2
Collagen alpha-2(I) chain

2

0

High-throughput

0.318

High

331822

SP16H
FACT complex subunit SPT16

2

0

High-throughput

0.318

High

261466

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

331758

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.279

Low

331764

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

331786

TRM61
tRNA

1

0

High-throughput

0.279

Low

331791

OPALI
Opalin

1

0

High-throughput

0.279

Low

76336

B4DNW6
Myosin IH, isoform CRA_a

1

0

High-throughput

0.249

Low

216358

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

Small-scale

0.249

Low

331723

DHE4
Glutamate dehydrogenase 2, mitochondrial

1

0

High-throughput

0.249

Low

331767

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

331783

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

331810

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.249

Low

331820

IFT52
Intraflagellar transport protein 52 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025