HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	31248990, 21293379
Identification Methods	proximity labelling technology, affinity chromatography technology, unspecified method, surface plasmon resonance, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 2089
+	Hs
		331740 NSD2_HUMAN (1-1365): 0: 980: 100.00		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		1056971 SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		1056940 NSD1_HUMAN (69-658): 1.83e-25: 117: 14.33		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		1018969 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		801165 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		801094 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		975277 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Hs
		1173276 KMT2B_HUMAN (1049-1203): 1.21e-41: 170: 32.05		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Hs
		1080263 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		MUC4_HUMAN (143-1535): 2.62e-31: 137: 12.14
+	Dm
		1215699 TRR_DROME (1073-1202): 6.82e-18: 92.4: 39.70		SPEN_DROME (86-1912): 1.19e-59: 231: 7.60
+	Hs
		152608 KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		975294 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72
+	Hs
		1080524 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		PRC2C_HUMAN (145-1944): 8.04e-16: 86.5: 8.07
+	Hs
		554310 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		MUC1_HUMAN (762-1525): 1.68e-11: 72: 18.23
+	Hs
		1080261 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		MINT_HUMAN (159-1473): 1.72e-10: 68.9: 10.33
+	Hs
		152660 KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Dm
		332845 CHDM_DROME (1238-1285): 6.78e-12: 72.7: 42.00		Q9VGW4_DROME (780-1440): 5.26e-09: 63.9: 12.93