Protein: MADD
MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP)

Gene: MADD
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q8WXG6

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005123 - death receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1214351

SYT6
Synaptotagmin-6

3

4

High-throughput

0.667

High

1308124

SYT12
Synaptotagmin-12

3

4

High-throughput

0.662

High

1311506

BBS7
BBSome complex member BBS7

3

0

High-throughput

0.634

High

1360616

SYT3
Synaptotagmin-3

2

4

High-throughput

0.628

High

318835

RHBT1
Rho-related BTB domain-containing protein 1

1

11

High-throughput

0.618

High

630595

RAB3B
Ras-related protein Rab-3B

1

4

High-throughput

0.618

High

901433

RAB7A
Ras-related protein Rab-7a

1

8

High-throughput

0.618

High

1360611

MTMR8
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8

2

9

High-throughput

0.611

High

327013

NXPH2
Neurexophilin-2

3

1

High-throughput

0.609

High

1360610

SNX21
Sorting nexin-21

3

1

High-throughput

0.604

High

488253

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.602

High

1360620

DOCK5
Dedicator of cytokinesis protein 5

2

0

High-throughput

0.602

High

1118537

TBB2A
Tubulin beta-2A chain

2

3

High-throughput

0.601

High

508348

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

2

High-throughput

0.595

High

990547

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.586

High

1164062

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

6

Small-scale

0.573

High

340194

PCNT
Pericentrin

1

3

High-throughput

0.541

High

1351915

RBCC1
RB1-inducible coiled-coil protein 1

1

3

High-throughput

0.541

High

193293

SOCS1
Suppressor of cytokine signaling 1

1

6

High-throughput

0.536

High

665122

COT2
COUP transcription factor 2

1

3

High-throughput

0.536

High

714640

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

15

High-throughput

0.536

High

783632

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.536

High

848051

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

1

High-throughput

0.536

High

871987

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

5

High-throughput

0.536

High

997446

TBB4B
Tubulin beta-4B chain

1

3

High-throughput

0.536

High

1006154

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

5

High-throughput

0.536

High

1108636

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.536

High

1191917

TBB8
Tubulin beta-8 chain

1

3

High-throughput

0.536

High

1286631

SYT9
Synaptotagmin-9

1

4

High-throughput

0.536

High

1331827

SYT2
Synaptotagmin-2

1

4

High-throughput

0.536

High

1349202

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

5

High-throughput

0.536

High

1360614

MTMR9
Myotubularin-related protein 9

1

9

High-throughput

0.536

High

1360621

ECT2
Protein ECT2

1

1

High-throughput

0.536

High

1360626

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

9

High-throughput

0.536

High

106358

APRIO
Alternative prion protein

2

3

High-throughput

0.533

High

1360619

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

2

3

High-throughput

0.533

High

658832

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

1

High-throughput

0.515

High

1339085

NUP37
Nucleoporin Nup37

1

2

High-throughput

0.515

High

472197

TRFM
Melanotransferrin

1

0

High-throughput

0.513

High

997058

TBA4A
Tubulin alpha-4A chain

1

0

High-throughput

0.513

High

1349075

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

1360631

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

1325811

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

1330819

TSYL6
Testis-specific Y-encoded-like protein 6

1

1

High-throughput

0.489

High

1332265

TAC2N
Tandem C2 domains nuclear protein

1

5

High-throughput

0.489

High

1357967

RN138
E3 ubiquitin-protein ligase RNF138

1

2

High-throughput

0.489

High

1360627

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

2

High-throughput

0.489

High

622648

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

0

Small-scale

0.480

High

156059

SOCS6
Suppressor of cytokine signaling 6

1

10

High-throughput

0.479

High

173144

XPO1
Exportin-1

1

5

High-throughput

0.479

High

218550

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

242427

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

294099

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

412336

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

762029

GRK5
G protein-coupled receptor kinase 5

1

2

High-throughput

0.479

High

995168

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.479

High

1049618

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1113851

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1254839

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1360617

CAB45
45 kDa calcium-binding protein

1

7

High-throughput

0.479

High

1360622

PIDD1
p53-induced death domain-containing protein 1

1

2

Small-scale

0.479

High

1360630

TR150
Thyroid hormone receptor-associated protein 3

1

1

High-throughput

0.470

High

568075

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

0

High-throughput

0.458

High

623463

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

814552

FEN1
Flap endonuclease 1

1

0

High-throughput

0.458

High

1360618

WNK1
Serine/threonine-protein kinase WNK1

1

1

High-throughput

0.457

High

944013

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

1010955

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.445

High

1360629

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

1360609

ESR2
Estrogen receptor beta

1

6

High-throughput

0.437

High

844844

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

1360623

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.426

High

1360624

S39A9
Zinc transporter ZIP9

1

0

High-throughput

0.426

High

1360628

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.426

High

327074

NXPH3
Neurexophilin-3

1

1

High-throughput

0.407

High

1360615

Q96T11
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.407

High

1360613

ANM6
Protein arginine N-methyltransferase 6

2

0

High-throughput

0.318

High

1360625

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.299

High

943282

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.282

High

342630

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

956089

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.279

Low

1310010

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

1316615

CDK20
Cyclin-dependent kinase 20

1

0

High-throughput

0.279

Low

1350846

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1360612

ZN625
Zinc finger protein 625

1

0

High-throughput

0.269

Low

1216553

VP13D
Intermembrane lipid transfer protein VPS13D

1

0

Small-scale

0.265

Low

1127039

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025