Protein: RN138
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)

Gene: RN138, RNF138
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q8WVD3

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0003697 - single-stranded DNA binding
GO:0005634 - nucleus
GO:0008270 - zinc ion binding
GO:0010792 - DNA double-strand break processing involved in repair via single-strand annealing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957637

UBE2K
Ubiquitin-conjugating enzyme E2 K

10

20

Small-scale

0.980

High

982261

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.698

High

1325740

LNX2
Ligand of Numb protein X 2

1

19

High-throughput

0.698

High

1357971

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1357999

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

1358001

ARI1
E3 ubiquitin-protein ligase ARIH1

1

17

High-throughput

0.691

High

1357977

NP1L5
Nucleosome assembly protein 1-like 5

4

2

High-throughput

0.691

High

279433

TULP3
Tubby-related protein 3

3

1

High-throughput

0.667

High

1158143

MK14
Mitogen-activated protein kinase 14

3

5

High-throughput

0.667

High

242408

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.665

High

508342

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

998592

H31
Histone H3.1

1

16

Small-scale

0.647

High

292383

RA51D
DNA repair protein RAD51 homolog 4

2

1

Small-scale

0.643

High

944156

WDR4
tRNA

2

12

High-throughput

0.628

High

1239635

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

8

High-throughput

0.628

High

1357996

LEF1
Lymphoid enhancer-binding factor 1

2

14

Small-scale

0.624

High

957454

UBC12
NEDD8-conjugating enzyme Ubc12

1

20

High-throughput

0.618

High

1197651

MIDN
Midnolin

1

1

High-throughput

0.618

High

1271298

5MP2
eIF5-mimic protein 2

3

2

High-throughput

0.609

High

1357987

TRPV5
Transient receptor potential cation channel subfamily V member 5

3

2

High-throughput

0.609

High

1357975

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

3

High-throughput

0.606

High

1357981

CSN8
COP9 signalosome complex subunit 8

2

0

High-throughput

0.602

High

622645

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

20

High-throughput

0.574

High

1357988

TF7L2
Transcription factor 7-like 2

1

14

Small-scale

0.561

High

351574

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

4

High-throughput

0.553

High

944892

PCBP4
Poly(rC)-binding protein 4

1

17

High-throughput

0.541

High

1357978

QKI
KH domain-containing RNA-binding protein QKI

1

9

High-throughput

0.541

High

1357984

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

19

High-throughput

0.541

High

230652

PRIC3
Prickle planar cell polarity protein 3

1

18

High-throughput

0.536

High

659542

CRCM
Colorectal mutant cancer protein

1

10

High-throughput

0.536

High

718438

CD6
T-cell differentiation antigen CD6

1

6

High-throughput

0.536

High

1036672

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

12

High-throughput

0.536

High

1272497

CSN6
COP9 signalosome complex subunit 6

1

5

High-throughput

0.536

High

1357970

CSN5
COP9 signalosome complex subunit 5

1

11

High-throughput

0.536

High

1357989

DPOE3
DNA polymerase epsilon subunit 3

1

1

High-throughput

0.536

High

1357991

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

7

High-throughput

0.536

High

1357994

RBX2
RING-box protein 2

1

3

High-throughput

0.536

High

1357998

PHF8
Histone lysine demethylase PHF8

1

9

High-throughput

0.536

High

75519

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

1159315

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.518

High

216761

HTRA2
Serine protease HTRA2, mitochondrial

1

2

High-throughput

0.515

High

386020

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.515

High

458453

ADRB2
Beta-2 adrenergic receptor

1

2

High-throughput

0.515

High

767280

MERL
Merlin

1

6

High-throughput

0.515

High

791574

SYUA
Alpha-synuclein

1

2

High-throughput

0.515

High

1096124

TADBP
TAR DNA-binding protein 43

1

20

High-throughput

0.515

High

1279664

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

8

High-throughput

0.515

High

1358000

RNF11
RING finger protein 11

1

4

High-throughput

0.515

High

1332085

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.513

High

1357974

CPNE2
Copine-2

1

0

High-throughput

0.513

High

414295

P53
Cellular tumor antigen p53

1

9

Small-scale

0.501

High

269319

HSF2B
Heat shock factor 2-binding protein

1

1

High-throughput

0.489

High

299776

MPDZ
Multiple PDZ domain protein

1

20

High-throughput

0.489

High

1311205

RHG12
Rho GTPase-activating protein 12

1

1

High-throughput

0.489

High

1339385

GP156
Probable G-protein coupled receptor 156

1

2

High-throughput

0.489

High

1357967

MADD
MAP kinase-activating death domain protein

1

2

High-throughput

0.489

High

1357979

CC85A
Coiled-coil domain-containing protein 85A

1

2

High-throughput

0.489

High

171289

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

7

High-throughput

0.479

High

173138

XPO1
Exportin-1

1

11

High-throughput

0.479

High

179380

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

High-throughput

0.479

High

260214

BRD4
Bromodomain-containing protein 4

1

14

High-throughput

0.479

High

320737

UBXN7
UBX domain-containing protein 7

1

5

High-throughput

0.479

High

325382

ZO3
Tight junction protein ZO-3

1

10

High-throughput

0.479

High

463677

LYN
Tyrosine-protein kinase Lyn

1

15

High-throughput

0.479

High

657640

GCSP
Glycine dehydrogenase

1

2

High-throughput

0.479

High

658299

RS3
Small ribosomal subunit protein uS3

1

5

Small-scale

0.479

High

691279

1433T
14-3-3 protein theta

1

16

High-throughput

0.479

High

764917

CTNB1
Catenin beta-1

1

12

High-throughput

0.479

High

774095

ADDA
Alpha-adducin

1

3

High-throughput

0.479

High

831131

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

887702

PSB2
Proteasome subunit beta type-2

1

7

Small-scale

0.479

High

996260

EF1A1
Elongation factor 1-alpha 1

1

8

Small-scale

0.479

High

1066414

RBBP4
Histone-binding protein RBBP4

1

13

Small-scale

0.479

High

1109934

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.479

High

1113836

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1135751

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.479

High

1280363

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

17

High-throughput

0.479

High

1357969

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

1

High-throughput

0.479

High

1357983

RBM4
RNA-binding protein 4

1

17

Small-scale

0.479

High

1357986

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1357990

LYAR
Cell growth-regulating nucleolar protein

1

2

Small-scale

0.479

High

1357995

ZRAN1
Ubiquitin thioesterase ZRANB1

1

20

High-throughput

0.479

High

1357997

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

3

High-throughput

0.479

High

1358002

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

12

High-throughput

0.479

High

109476

G5E9A7
DM1 locus, WD repeat containing

1

17

High-throughput

0.470

High

246071

KIF1B
Kinesin-like protein KIF1B

1

12

High-throughput

0.470

High

374811

RASH
GTPase HRas

1

10

High-throughput

0.470

High

442421

GELS
Gelsolin

1

1

High-throughput

0.470

High

650323

FGFR3
Fibroblast growth factor receptor 3

1

10

High-throughput

0.470

High

705488

GRN
Progranulin

1

2

High-throughput

0.470

High

1357968

JPH3
Junctophilin-3

1

1

High-throughput

0.470

High

837746

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

1357982

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.458

High

422722

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.457

High

294737

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

1

High-throughput

0.445

High

1314326

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.445

High

294086

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

418713

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

4

High-throughput

0.437

High

569205

CD59
CD59 glycoprotein

1

1

High-throughput

0.437

High

867298

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.437

High

989859

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

4

High-throughput

0.437

High

1117421

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

10

High-throughput

0.437

High

1247748

NHS
Actin remodeling regulator NHS

1

11

High-throughput

0.437

High

1250744

MPRIP
Myosin phosphatase Rho-interacting protein

1

15

High-throughput

0.437

High

1290343

SERC5
Serine incorporator 5

1

4

Small-scale

0.437

High

1348161

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

1357985

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

15

High-throughput

0.437

High

1357992

TMOD3
Tropomodulin-3

1

7

High-throughput

0.437

High

1357993

RAI14
Ankycorbin

1

17

High-throughput

0.437

High

944006

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

20

High-throughput

0.407

High

321929

FRYL
Protein furry homolog-like

2

0

High-throughput

0.328

High

1315503

DAAF8
Dynein axonemal assembly factor 8

2

0

High-throughput

0.328

High

1331717

NECA1
N-terminal EF-hand calcium-binding protein 1

2

0

High-throughput

0.328

High

1357972

F136A
Protein FAM136A

2

0

High-throughput

0.328

High

1315374

CF206
Cilia- and flagella-associated protein 206

1

0

High-throughput

0.282

High

1216387

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

1357976

CC120
Coiled-coil domain-containing protein 120

1

0

High-throughput

0.279

Low

47383

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

1133904

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

0

High-throughput

0.268

Low

1159353

FRDA
Frataxin, mitochondrial

1

0

High-throughput

0.268

Low

1214459

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

1

0

High-throughput

0.268

Low

1292913

Q86WV8
TSC complex subunit 1

1

0

High-throughput

0.268

Low

1358003

Q9Y649
GW128

1

0

High-throughput

0.268

Low

1357973

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.249

Low

1357980

TPPC9
Trafficking protein particle complex subunit 9

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025